| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 380 | 1,214 | 3.19 | 202 | 53.16% | 82 | 21.58% | 96 | 25.26% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Atlanta United | 33 | 21 | 6 | 6 | 69 | 40 | +29 | 69 | WWLW | 17 | 11 | 4 | 2 | 42 | 19 | 16 | 10 | 2 | 4 | 27 | 21 | ||
| 2 | New York Red Bulls | 33 | 21 | 5 | 7 | 61 | 33 | +28 | 68 | WWWW | 16 | 13 | 1 | 2 | 35 | 10 | 17 | 8 | 4 | 5 | 26 | 23 | ||
| 3 | New York City | 33 | 15 | 8 | 10 | 56 | 44 | +12 | 53 | LLWX | 16 | 11 | 4 | 1 | 33 | 9 | 17 | 4 | 4 | 9 | 23 | 35 | ||
| 4 | Philadelphia Union | 33 | 15 | 5 | 13 | 48 | 47 | +1 | 50 | LWOW | 17 | 9 | 2 | 6 | 29 | 20 | 16 | 6 | 3 | 7 | 19 | 27 | ||
| 5 | 1 | D.C. United | 33 | 14 | 8 | 11 | 60 | 50 | +10 | 50 | WWWW | 17 | 13 | 2 | 2 | 37 | 17 | 16 | 1 | 6 | 9 | 23 | 33 | |
| 6 | 1 | Columbus Crew | 33 | 13 | 9 | 11 | 40 | 43 | -3 | 48 | LLOW | 16 | 10 | 4 | 2 | 29 | 19 | 17 | 3 | 5 | 9 | 11 | 24 | |
| 7 | Montréal Impact | 33 | 14 | 4 | 15 | 47 | 52 | -5 | 46 | WWLX | 17 | 11 | 2 | 4 | 31 | 16 | 16 | 3 | 2 | 11 | 16 | 36 | ||
| 8 | New England Revolution | 33 | 9 | 11 | 13 | 48 | 55 | -7 | 38 | LWLL | 16 | 7 | 5 | 4 | 27 | 20 | 17 | 2 | 6 | 9 | 21 | 35 | ||
| 9 | Toronto FC | 33 | 9 | 6 | 18 | 55 | 63 | -8 | 33 | LLLW | 16 | 7 | 2 | 7 | 35 | 28 | 17 | 2 | 4 | 11 | 20 | 35 | ||
| 10 | Chicago Fire | 33 | 8 | 7 | 18 | 48 | 61 | -13 | 31 | LLWL | 16 | 6 | 3 | 7 | 28 | 25 | 17 | 2 | 4 | 11 | 20 | 36 | ||
| 11 | Orlando City | 33 | 8 | 4 | 21 | 43 | 73 | -30 | 28 | WLLL | 17 | 6 | 4 | 7 | 28 | 30 | 16 | 2 | 0 | 14 | 15 | 43 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | Sporting Kansas City | 33 | 17 | 8 | 8 | 63 | 39 | +24 | 59 | WWXX | 16 | 9 | 5 | 2 | 32 | 16 | 17 | 8 | 3 | 6 | 31 | 23 | |
| 2 | Los Angeles | 33 | 16 | 9 | 8 | 67 | 50 | +17 | 57 | XWWL | 17 | 9 | 7 | 1 | 32 | 15 | 16 | 7 | 2 | 7 | 35 | 35 | ||
| 3 | 2 | FC Dallas | 33 | 16 | 9 | 8 | 51 | 42 | +9 | 57 | LLWO | 17 | 10 | 5 | 2 | 32 | 19 | 16 | 6 | 4 | 6 | 19 | 23 | |
| 4 | 1 | Seattle Sounders | 33 | 17 | 5 | 11 | 50 | 36 | +14 | 56 | WWWW | 16 | 9 | 2 | 5 | 31 | 14 | 17 | 8 | 3 | 6 | 19 | 22 | |
| 5 | 1 | Portland Timbers | 33 | 15 | 9 | 9 | 53 | 46 | +7 | 54 | WWOL | 17 | 11 | 4 | 2 | 30 | 13 | 16 | 4 | 5 | 7 | 23 | 33 | |
| 6 | Real Salt Lake | 34 | 14 | 7 | 13 | 55 | 58 | -3 | 49 | LWLX | 17 | 11 | 4 | 2 | 38 | 24 | 17 | 3 | 3 | 11 | 17 | 34 | ||
| 7 | LA Galaxy | 33 | 13 | 9 | 11 | 64 | 61 | +3 | 48 | WXWW | 16 | 8 | 4 | 4 | 35 | 24 | 17 | 5 | 5 | 7 | 29 | 37 | ||
| 8 | Vancouver Whitecaps | 33 | 12 | 8 | 13 | 52 | 66 | -14 | 44 | XLWL | 16 | 6 | 5 | 5 | 30 | 28 | 17 | 6 | 3 | 8 | 22 | 38 | ||
| 9 | Minnesota United | 33 | 11 | 3 | 19 | 47 | 68 | -21 | 36 | LLLW | 17 | 10 | 1 | 6 | 30 | 25 | 16 | 1 | 2 | 13 | 17 | 43 | ||
| 10 | Houston Dynamo | 33 | 9 | 8 | 16 | 55 | 56 | -1 | 35 | LLLW | 17 | 8 | 3 | 6 | 36 | 24 | 16 | 1 | 5 | 10 | 19 | 32 | ||
| 11 | Colorado Rapids | 33 | 7 | 7 | 19 | 34 | 62 | -28 | 28 | OWLL | 16 | 5 | 3 | 8 | 22 | 31 | 17 | 2 | 4 | 11 | 12 | 31 | ||
| 12 | San Jose Earthquakes | 33 | 4 | 9 | 20 | 48 | 69 | -21 | 21 | OLLL | 17 | 2 | 6 | 9 | 27 | 39 | 16 | 2 | 3 | 11 | 21 | 30 | ||
| 30 | Josef MARTÍNEZ (Atlanta United, 7p) | |
| 22 | +1 | Zlatan IBRAHIMOVIĆ (LA Galaxy, 4p) |
| 20 | Bradley WRIGHT-PHILLIPS (New York Red Bulls) | |
| 17 | +1 | Mauro MANOTAS (Houston Dynamo, 1p) |
| 16 | +2 | Ignacio PIATTI (Montréal Impact, 4p) |
| Gyasi ZARDES (Columbus Crew, 3p) | ||
| 15 | Nemanja NIKOLIĆ (Chicago Fire, 3p) | |
| 14 | Kei KAMARA (Vancouver Whitecaps, 3p) | |
| 13 | +1 | Dominic DWYER (Orlando City) |
| Carlos VELA (Los Angeles, 3p) | ||
| +1 | David VILLA (New York City, 2p) | |
| 12 | Adama DIOMANDE (Los Angeles) | |
| +1 | Ola KAMARA (LA Galaxy) | |
| Cristian PENILLA (New England Revolution, 1p) | ||
| Miguel ALMIRON (Atlanta United, 4p) | ||
| +2 | Diego ROSSI (Los Angeles) | |
| Sebastian GIOVINCO (Toronto FC, 1p) | ||
| +3 | Wayne ROONEY (D.C. United, 3p) | |
| +1 | Damir KREILACH (Real Salt Lake) | |
| Aleksandar KATAI (Chicago Fire) | ||
| Danny HOESEN (San Jose Earthquakes) |
| Wednesday, 17 October 2018 | |||||
| D.C. United | 1-0 | Toronto FC | |||
| 18 | Rooney | ||||
| Vancouver Whitecaps | 1-4 | Sporting Kansas City | |||
| 42 | Felipe | 62 | Croizet | ||
| 82 | Sallói | ||||
| 90 | Busio | ||||
| 90 | Sallói | ||||
| Orlando City | 1-2 | Seattle Sounders | |||
| 57 | Dwyer | 3 | Víctor | ||
| 13 | Bwana | ||||
| Thursday, 18 October 2018 | |||||
| Real Salt Lake | 4-1 | New England Revolution | |||
| 4 | Besler | 69 | Rowe | ||
| 14 | Saucedo | ||||
| 29 | Baird | ||||
| 50 | Kreilach | ||||
| Sunday, 21 October 2018 | |||||
| D.C. United | 3-1 | New York City | |||
| 8 | Rooney | 78 | Villa | ||
| 24 | Acosta | ||||
| 74(p) | Rooney | ||||
| FC Dallas | 0-3 | Sporting Kansas City | |||
| 45 | Sallói | ||||
| 64 | Espinoza | ||||
| 87(p) | Russell | ||||
| Houston Dynamo | 2-3 | Seattle Sounders | |||
| 63 | Garcia | 26 | Marshall | ||
| 89 | Manotas | 49 | Svensson | ||
| 87 | Ruidíaz | ||||
| Montréal Impact | 2-0 | Toronto FC | |||
| 74(p) | Piatti | ||||
| 89 | Piatti | ||||
| Portland Timbers | 3-0 | Real Salt Lake | |||
| 15 | Mabiala | ||||
| 68 | Chará | ||||
| 87 | Blanco | ||||
| San Jose Earthquakes | 0-0 | Colorado Rapids | |||
| Orlando City | 2-1 | Columbus Crew | |||
| 57(p) | Yotún | 54 | Higuaín | ||
| 90(p) | Kljestan | ||||
| Philadelphia Union | 0-1 | New York Red Bulls | |||
| 69(p) | Romero | ||||
| Minnesota United | 1-3 | LA Galaxy | |||
| 53 | Rodríguez | 30 | Ibrahimović | ||
| 50 | Kamara | ||||
| 51 | Alessandrini | ||||
| Los Angeles | 2-2 | Vancouver Whitecaps | |||
| 5 | Rossi | 22(p) | Reyna | ||
| 15 | Rossi | 65 | Mutch | ||
| Atlanta United | 2-1 | Chicago Fire | |||
| 9 | Escobar | 24 | De Leeuw | ||
| 26(og) | Kappelhof | ||||