| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 56 | 141 | 2.51 | 28 | 50.00% | 11 | 19.64% | 17 | 30.36% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 5 | 3 | 2 | 0 | 6 | 1 | +5 | 11 | OXWW | 3 | 2 | 1 | 0 | 4 | 1 | 2 | 1 | 1 | 0 | 2 | 0 | ||
| 2 | 1 | Pittsburgh Riverhounds | 4 | 3 | 1 | 0 | 8 | 2 | +6 | 10 | WXWW | 2 | 2 | 0 | 0 | 4 | 1 | 2 | 1 | 1 | 0 | 4 | 1 | |
| 3 | 1 | Tampa Bay Rowdies | 5 | 2 | 3 | 0 | 7 | 2 | +5 | 9 | OXWW | 2 | 1 | 1 | 0 | 3 | 1 | 3 | 1 | 2 | 0 | 4 | 1 | |
| 4 | 1 | FC Tulsa | 5 | 3 | 0 | 2 | 8 | 6 | +2 | 9 | WLWW | 3 | 3 | 0 | 0 | 7 | 3 | 2 | 0 | 0 | 2 | 1 | 3 | |
| 5 | 1 | Loudoun United | 4 | 2 | 1 | 1 | 4 | 2 | +2 | 7 | LOWW | 1 | 1 | 0 | 0 | 1 | 0 | 3 | 1 | 1 | 1 | 3 | 2 | |
| 6 | Memphis 901 | 4 | 2 | 1 | 1 | 4 | 5 | -1 | 7 | XWWL | 2 | 1 | 0 | 1 | 2 | 4 | 2 | 1 | 1 | 0 | 2 | 1 | ||
| 7 | 7 | Atlanta United 2 | 5 | 2 | 0 | 3 | 6 | 7 | -1 | 6 | WWLL | 3 | 1 | 0 | 2 | 4 | 5 | 2 | 1 | 0 | 1 | 2 | 2 | |
| 8 | Detroit City | 4 | 1 | 2 | 1 | 3 | 3 | +0 | 5 | XXWL | 3 | 1 | 2 | 0 | 3 | 2 | 1 | 0 | 0 | 1 | 0 | 1 | ||
| 9 | 2 | Miami FC | 4 | 1 | 1 | 2 | 3 | 4 | -1 | 4 | LOLW | 3 | 1 | 1 | 1 | 3 | 2 | 1 | 0 | 0 | 1 | 0 | 2 | |
| 10 | 1 | Charleston Battery | 4 | 1 | 0 | 3 | 3 | 7 | -4 | 3 | LLLW | 2 | 1 | 0 | 1 | 2 | 2 | 2 | 0 | 0 | 2 | 1 | 5 | |
| 11 | 1 | New York Red Bulls 2 | 5 | 1 | 0 | 4 | 3 | 10 | -7 | 3 | LLLW | 2 | 0 | 0 | 2 | 0 | 5 | 3 | 1 | 0 | 2 | 3 | 5 | |
| 12 | Indy Eleven | 4 | 0 | 2 | 2 | 2 | 5 | -3 | 2 | XXLL | 1 | 0 | 1 | 0 | 1 | 1 | 3 | 0 | 1 | 2 | 1 | 4 | ||
| 13 | Birmingham Legion | 4 | 0 | 2 | 2 | 2 | 6 | -4 | 2 | OLLX | 3 | 0 | 2 | 1 | 1 | 3 | 1 | 0 | 0 | 1 | 1 | 3 | ||
| 14 | 3 | Hartford Athletic | 3 | 0 | 1 | 2 | 3 | 5 | -2 | 1 | LXL- | 1 | 0 | 0 | 1 | 1 | 2 | 2 | 0 | 1 | 1 | 2 | 3 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Colorado Springs | 4 | 4 | 0 | 0 | 7 | 2 | +5 | 12 | WWWW | 2 | 2 | 0 | 0 | 3 | 1 | 2 | 2 | 0 | 0 | 4 | 1 | ||
| 2 | San Diego Loyal | 4 | 3 | 0 | 1 | 7 | 4 | +3 | 9 | WLWW | 2 | 2 | 0 | 0 | 4 | 1 | 2 | 1 | 0 | 1 | 3 | 3 | ||
| 3 | 5 | Sacramento Republic | 4 | 3 | 0 | 1 | 7 | 5 | +2 | 9 | WWLW | 3 | 3 | 0 | 0 | 7 | 3 | 1 | 0 | 0 | 1 | 0 | 2 | |
| 4 | San Antonio | 4 | 3 | 0 | 1 | 5 | 4 | +1 | 9 | LWWW | 2 | 1 | 0 | 1 | 1 | 2 | 2 | 2 | 0 | 0 | 4 | 2 | ||
| 5 | Las Vegas Lights | 5 | 3 | 0 | 2 | 9 | 9 | +0 | 9 | WLWW | 2 | 1 | 0 | 1 | 2 | 2 | 3 | 2 | 0 | 1 | 7 | 7 | ||
| 6 | 3 | New Mexico United | 4 | 2 | 2 | 0 | 7 | 4 | +3 | 8 | XXWW | 3 | 1 | 2 | 0 | 5 | 3 | 1 | 1 | 0 | 0 | 2 | 1 | |
| 7 | Phoenix Rising | 4 | 2 | 0 | 2 | 9 | 7 | +2 | 6 | WLLW | 2 | 1 | 0 | 1 | 6 | 5 | 2 | 1 | 0 | 1 | 3 | 2 | ||
| 8 | 2 | Orange County SC | 3 | 1 | 1 | 1 | 4 | 4 | +0 | 4 | XWL- | 1 | 1 | 0 | 0 | 2 | 1 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 9 | LA Galaxy 2 | 4 | 1 | 1 | 2 | 4 | 5 | -1 | 4 | XWLL | 2 | 1 | 0 | 1 | 2 | 2 | 2 | 0 | 1 | 1 | 2 | 3 | ||
| 10 | RGV Toros | 4 | 1 | 0 | 3 | 3 | 5 | -2 | 3 | LLLW | 2 | 1 | 0 | 1 | 2 | 2 | 2 | 0 | 0 | 2 | 1 | 3 | ||
| 11 | Monterey Bay | 4 | 1 | 0 | 3 | 6 | 9 | -3 | 3 | LWLL | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3 | 6 | 9 | ||
| 12 | Oakland Roots | 5 | 0 | 2 | 3 | 5 | 8 | -3 | 2 | OXLL | 2 | 0 | 1 | 1 | 2 | 3 | 3 | 0 | 1 | 2 | 3 | 5 | ||
| 13 | El Paso Locomotive | 3 | 0 | 0 | 3 | 6 | 10 | -4 | 0 | LLL- | 2 | 0 | 0 | 2 | 5 | 7 | 1 | 0 | 0 | 1 | 1 | 3 | ||
| 5 | +2 | Danny TREJO (Las Vegas Lights) |
| 3 | +1 | Michee NGALINA (Colorado Springs) |
| +3 | Jackson CONWAY (Atlanta United 2) | |
| Jake LACAVA (Tampa Bay Rowdies) | ||
| +1 | Chase BOONE (Monterey Bay) | |
| +1 | Neco BRETT (New Mexico United) | |
| +2 | Dane KELLY (Pittsburgh Riverhounds) | |
| 2 | Milan ILOSKI (Orange County SC) | |
| +1 | David LOERA (San Antonio) | |
| +1 | Augustine WILLIAMS (Charleston Battery, 1p) | |
| Tyler FREEMAN (Loudoun United) | ||
| Dylan MARES (El Paso Locomotive) | ||
| +2 | Jerome 'J.J.' WILLIAMS (FC Tulsa) | |
| Albert DIKWA (Pittsburgh Riverhounds) | ||
| +1 | Rodrigo LÓPEZ (Sacramento Republic, 2p) | |
| +1 | RODRIGO BANDEIRA da Costa (FC Tulsa) | |
| +2 | Nick FIRMINO (Atlanta United 2) | |
| Harry SWARTZ (New Mexico United) | ||
| +1 | Douglas MARTÍNEZ (Sacramento Republic, 1p) | |
| Frank LÓPEZ (RGV Toros) | ||
| Sean OKOLI (Orange County SC) | ||
| Wilson HARRIS (Louisville City) | ||
| Óttar KARLSSON (Oakland Roots, 1p) | ||
| Sebastian DALGAARD (Tampa Bay Rowdies) | ||
| Cal JENNINGS (Las Vegas Lights) | ||
| +1 | Claudio REPETTO (Phoenix Rising) |
| Sunday, 27 March 2022 | |||||
| Sacramento Republic | 2-1 | FC Tulsa | |||
| 33(p) | Martínez | 29 | Rodrigo Bandeira | ||
| 86 | Lacroix | ||||
| RGV Toros | 1-2 | San Antonio | |||
| 44 | Borczak | 34 | Collier | ||
| 45 | Loera | ||||
| Atlanta United 2 | 4-1 | Charleston Battery | |||
| 56 | Conway | 6 | Apodaca | ||
| 63 | Conway | ||||
| 78 | Conway | ||||
| 90 | Matheus | ||||
| Wednesday, 30 March 2022 | |||||
| New Mexico United | 2-2 | Oakland Roots | |||
| 45 | Brett | 8 | Dennis | ||
| 69 | Rivas | 90 | Morad | ||
| Friday, 1 April 2022 | |||||
| Charleston Battery | 1-2 | Las Vegas Lights | |||
| 8(p) | Williams | 45 | Trejo | ||
| 56 | Trejo | ||||
| Saturday, 2 April 2022 | |||||
| Pittsburgh Riverhounds | 2-0 | Loudoun United | |||
| 65 | Kelly | ||||
| 73 | Kelly | ||||
| San Antonio | 0-2 | Phoenix Rising | |||
| 56 | Repetto | ||||
| 90 | Epps | ||||
| Indy Eleven | 1-1 | LA Galaxy 2 | |||
| 61 | Aguilera | 35 | Salazar | ||
| Sacramento Republic | 2-1 | Monterey Bay | |||
| 78(p) | López | 90 | Boone | ||
| 87(p) | Archimède | ||||
| FC Tulsa | 3-2 | New York Red Bulls 2 | |||
| 20 | Williams | 17 | Rafanello | ||
| 25 | Torres | 70 | Murphy | ||
| 46 | Williams | ||||
| Miami FC | 1-2 | Colorado Springs | |||
| 77 | Parkes | 4 | Barry | ||
| 68 | Ngalina | ||||
| Birmingham Legion | 0-0 | Louisville City | |||
| Hartford Athletic | 1-2 | Atlanta United 2 | |||
| 70(og) | Cobb | 45 | Firmino | ||
| 58 | Firmino | ||||
| Detroit City | 1-1 | Memphis 901 | |||
| 73 | Botello | 28 | Goodrum | ||
| Oakland Roots | 0-0 | Tampa Bay Rowdies | |||