| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 404 | 1,173 | 2.90 | 188 | 46.53% | 85 | 21.04% | 131 | 32.43% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 30 | 19 | 6 | 5 | 59 | 24 | +35 | 63 | WOXW | 14 | 11 | 2 | 1 | 33 | 10 | 16 | 8 | 4 | 4 | 26 | 14 | ||
| 2 | Memphis 901 | 29 | 18 | 4 | 7 | 58 | 28 | +30 | 58 | WWXL | 15 | 10 | 0 | 5 | 36 | 19 | 14 | 8 | 4 | 2 | 22 | 9 | ||
| 3 | Tampa Bay Rowdies | 29 | 16 | 6 | 7 | 58 | 30 | +28 | 54 | LLWW | 13 | 9 | 2 | 2 | 28 | 11 | 16 | 7 | 4 | 5 | 30 | 19 | ||
| 4 | Birmingham Legion | 30 | 16 | 6 | 8 | 50 | 31 | +19 | 54 | WLXW | 15 | 8 | 4 | 3 | 25 | 12 | 15 | 8 | 2 | 5 | 25 | 19 | ||
| 5 | Pittsburgh Riverhounds | 30 | 15 | 7 | 8 | 45 | 34 | +11 | 52 | LOWO | 14 | 8 | 4 | 2 | 21 | 12 | 16 | 7 | 3 | 6 | 24 | 22 | ||
| 6 | 1 | Detroit City | 30 | 13 | 11 | 6 | 37 | 25 | +12 | 50 | OWWO | 15 | 6 | 7 | 2 | 19 | 13 | 15 | 7 | 4 | 4 | 18 | 12 | |
| 7 | 1 | Miami FC | 30 | 13 | 9 | 8 | 43 | 29 | +14 | 48 | XWXW | 15 | 4 | 6 | 5 | 17 | 18 | 15 | 9 | 3 | 3 | 26 | 11 | |
| 8 | FC Tulsa | 30 | 10 | 5 | 15 | 40 | 51 | -11 | 35 | LXLW | 15 | 8 | 3 | 4 | 25 | 20 | 15 | 2 | 2 | 11 | 15 | 31 | ||
| 9 | 1 | Hartford Athletic | 31 | 9 | 6 | 16 | 39 | 49 | -10 | 33 | LWWW | 15 | 6 | 1 | 8 | 21 | 22 | 16 | 3 | 5 | 8 | 18 | 27 | |
| 10 | 1 | Indy Eleven | 29 | 9 | 5 | 15 | 32 | 47 | -15 | 32 | LWOW | 14 | 7 | 2 | 5 | 19 | 17 | 15 | 2 | 3 | 10 | 13 | 30 | |
| 11 | 1 | Loudoun United | 30 | 8 | 3 | 19 | 35 | 60 | -25 | 27 | WLLL | 16 | 6 | 2 | 8 | 22 | 26 | 14 | 2 | 1 | 11 | 13 | 34 | |
| 12 | 1 | Charleston Battery | 30 | 6 | 6 | 18 | 36 | 63 | -27 | 24 | LWWO | 15 | 5 | 1 | 9 | 22 | 31 | 15 | 1 | 5 | 9 | 14 | 32 | |
| 13 | Atlanta United 2 | 31 | 5 | 5 | 21 | 35 | 80 | -45 | 20 | XLWL | 16 | 3 | 4 | 9 | 18 | 35 | 15 | 2 | 1 | 12 | 17 | 45 | ||
| 14 | New York Red Bulls 2 | 31 | 3 | 6 | 22 | 22 | 68 | -46 | 15 | OLLL | 17 | 2 | 5 | 10 | 14 | 33 | 14 | 1 | 1 | 12 | 8 | 35 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Antonio | 30 | 21 | 4 | 5 | 48 | 23 | +25 | 67 | WXWW | 15 | 10 | 4 | 1 | 28 | 9 | 15 | 11 | 0 | 4 | 20 | 14 | ||
| 2 | San Diego Loyal | 30 | 17 | 4 | 9 | 61 | 45 | +16 | 55 | WLLL | 16 | 12 | 0 | 4 | 37 | 21 | 14 | 5 | 4 | 5 | 24 | 24 | ||
| 3 | Colorado Springs | 31 | 16 | 3 | 12 | 54 | 49 | +5 | 51 | LLLW | 16 | 10 | 2 | 4 | 34 | 23 | 15 | 6 | 1 | 8 | 20 | 26 | ||
| 4 | Sacramento Republic | 29 | 14 | 7 | 8 | 43 | 29 | +14 | 49 | WWLW | 14 | 9 | 4 | 1 | 27 | 9 | 15 | 5 | 3 | 7 | 16 | 20 | ||
| 5 | 1 | El Paso Locomotive | 31 | 12 | 7 | 12 | 52 | 44 | +8 | 43 | WLWW | 15 | 7 | 2 | 6 | 30 | 18 | 16 | 5 | 5 | 6 | 22 | 26 | |
| 6 | 1 | New Mexico United | 30 | 11 | 10 | 9 | 41 | 35 | +6 | 43 | XLLL | 15 | 4 | 5 | 6 | 20 | 18 | 15 | 7 | 5 | 3 | 21 | 17 | |
| 7 | 1 | RGV Toros | 29 | 11 | 6 | 12 | 40 | 35 | +5 | 39 | WWWL | 14 | 6 | 2 | 6 | 15 | 14 | 15 | 5 | 4 | 6 | 25 | 21 | |
| 8 | 1 | Oakland Roots | 30 | 9 | 12 | 9 | 44 | 40 | +4 | 39 | WWLL | 16 | 6 | 5 | 5 | 24 | 21 | 14 | 3 | 7 | 4 | 20 | 19 | |
| 9 | 2 | Monterey Bay | 29 | 12 | 3 | 14 | 40 | 47 | -7 | 39 | XWWW | 16 | 8 | 3 | 5 | 26 | 18 | 13 | 4 | 0 | 9 | 14 | 29 | |
| 10 | 3 | Las Vegas Lights | 29 | 10 | 7 | 12 | 31 | 45 | -14 | 37 | LLLW | 13 | 5 | 2 | 6 | 15 | 19 | 16 | 5 | 5 | 6 | 16 | 26 | |
| 11 | 1 | LA Galaxy 2 | 30 | 10 | 6 | 14 | 47 | 56 | -9 | 36 | LLLW | 14 | 6 | 3 | 5 | 29 | 28 | 16 | 4 | 3 | 9 | 18 | 28 | |
| 12 | Phoenix Rising | 30 | 9 | 6 | 15 | 40 | 54 | -14 | 33 | XLLL | 15 | 7 | 3 | 5 | 24 | 19 | 15 | 2 | 3 | 10 | 16 | 35 | ||
| 13 | Orange County SC | 30 | 7 | 10 | 13 | 43 | 52 | -9 | 31 | LWLX | 16 | 5 | 7 | 4 | 26 | 22 | 14 | 2 | 3 | 9 | 17 | 30 | ||
| 20 | Milan ILOSKI (Orange County SC) | |
| 19 | +2 | Phillip GOODRUM (Memphis 901) |
| 16 | Hadji BARRY (Colorado Springs, 3p) | |
| +1 | Óttar KARLSSON (Oakland Roots, 6p) | |
| 15 | Leonardo FERNANDES (Tampa Bay Rowdies, 5p) | |
| +1 | Luis SOLIGNAC (El Paso Locomotive, 1p) | |
| 14 | Augustine WILLIAMS (Charleston Battery, 2p) | |
| 13 | +1 | Kyle VASSELL (San Diego Loyal, 1p) |
| Enzo MARTÍNEZ (Birmingham Legion) | ||
| 12 | Russell CICERONE (Pittsburgh Riverhounds) | |
| Elvis AMOH (Colorado Springs) | ||
| Preston JUDD (LA Galaxy 2) | ||
| +1 | Wilson HARRIS (Louisville City, 1p) | |
| 11 | Jerome 'J.J.' WILLIAMS (Phoenix Rising) | |
| Jake LACAVA (Tampa Bay Rowdies) | ||
| 10 | STÉFANO Souza (Indy Eleven, 1p) | |
| Jackson CONWAY (Atlanta United 2) | ||
| +1 | Dylan MARES (El Paso Locomotive) | |
| Albert DIKWA (Pittsburgh Riverhounds) | ||
| +1 | Kyle MURPHY (Miami FC, 2p) | |
| +1 | Cameron DUNBAR (LA Galaxy 2, 3p) | |
| Danny TREJO (Las Vegas Lights) | ||
| +1 | Enoch MUSHAGALUSA (Louisville City) |
| Friday, 16 September 2022 | |||||
| Memphis 901 | 5-0 | Charleston Battery | |||
| 8 | Goodrum | ||||
| 12 | Goodrum | ||||
| 30 | Kissiedou | ||||
| 72 | Carroll | ||||
| 90 | Pickering | ||||
| Saturday, 17 September 2022 | |||||
| San Antonio | 1-1 | New Mexico United | |||
| 54 | Bailone | 66 | Wehan | ||
| Louisville City | 4-2 | Loudoun United | |||
| 4 | Mushagalusa | 44 | Ku-Dipietro | ||
| 20 | Harris | 62 | Diarra | ||
| 25(p) | Totsch | ||||
| 64 | Ownby | ||||
| RGV Toros | 1-0 | Colorado Springs | |||
| 29 | Fjeldberg | ||||
| Miami FC | 2-2 | Atlanta United 2 | |||
| 45 | Chapman-Page | 57 | Matheus | ||
| 70 | Murphy | 81(og) | Pérez | ||
| Hartford Athletic | 3-0 | Las Vegas Lights | |||
| 12 | Martínez | ||||
| 28 | Martínez | ||||
| 79 | Brewitt | ||||
| San Diego Loyal | 3-0 | Phoenix Rising | |||
| 54 | Conway | ||||
| 64 | Vassell | ||||
| 77 | Kasanzu | ||||
| Detroit City | 1-0 | Tampa Bay Rowdies | |||
| 81 | Hoppenot | ||||
| Oakland Roots | 1-0 | New York Red Bulls 2 | |||
| 76 | Karlsson | ||||
| Monterey Bay | 5-0 | Indy Eleven | |||
| 31 | Boone | ||||
| 43 | Boone | ||||
| 49 | Murphy | ||||
| 50 | Gleadle | ||||
| 66 | Volesky | ||||
| Sunday, 18 September 2022 | |||||
| Sacramento Republic | 4-0 | Orange County SC | |||
| 7 | Dami | ||||
| 18 | López | ||||
| 28 | Foster | ||||
| 45 | Foster | ||||
| LA Galaxy 2 | 2-3 | El Paso Locomotive | |||
| 58(p) | Dunbar | 5 | Mares | ||
| 70 | Cabral | 21 | Solignac | ||
| 60 | Calvillo | ||||
| Tuesday, 20 September 2022 | |||||
| San Antonio | 1-0 | Colorado Springs | |||
| 76 | Pc | ||||
| Wednesday, 21 September 2022 | |||||
| New York Red Bulls 2 | 0-0 | Detroit City | |||
| Loudoun United | 3-0 | Hartford Athletic | |||
| 50 | Ku-Dipietro | ||||
| 71 | Freeman | ||||
| 74 | Freeman | ||||
| Monterey Bay | 3-3 | Phoenix Rising | |||
| 9 | Volesky | 15(p) | Quinn | ||
| 20 | Robinson | 40(p) | Quinn | ||
| 44 | Volesky | 75 | Hurst | ||