Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 476 | 1,409 | 2.96 | 232 | 48.74% | 118 | 24.79% | 126 | 26.47% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 34 | 19 | 10 | 5 | 72 | 26 | +46 | 67 | WLOW | 17 | 12 | 5 | 0 | 49 | 9 | 17 | 7 | 5 | 5 | 23 | 17 | ||
| 2 | CF Montréal | 34 | 20 | 5 | 9 | 63 | 50 | +13 | 65 | WWWW | 17 | 9 | 3 | 5 | 30 | 21 | 17 | 11 | 2 | 4 | 33 | 29 | ||
| 3 | 1 | New York City | 34 | 16 | 7 | 11 | 57 | 41 | +16 | 55 | WWWL | 17 | 10 | 4 | 3 | 37 | 19 | 17 | 6 | 3 | 8 | 20 | 22 | |
| 4 | 1 | New York Red Bulls | 34 | 15 | 8 | 11 | 50 | 41 | +9 | 53 | WLLW | 17 | 6 | 5 | 6 | 26 | 22 | 17 | 9 | 3 | 5 | 24 | 19 | |
| 5 | 1 | FC Cincinnati | 34 | 12 | 13 | 9 | 64 | 56 | +8 | 49 | WLXW | 17 | 6 | 6 | 5 | 37 | 27 | 17 | 6 | 7 | 4 | 27 | 29 | |
| 6 | 1 | Inter Miami | 34 | 14 | 6 | 14 | 47 | 56 | -9 | 48 | LWWW | 17 | 10 | 3 | 4 | 34 | 28 | 17 | 4 | 3 | 10 | 13 | 28 | |
| 7 | 2 | Orlando City | 34 | 14 | 6 | 14 | 44 | 53 | -9 | 48 | WLLW | 17 | 9 | 0 | 8 | 26 | 28 | 17 | 5 | 6 | 6 | 18 | 25 | |
| 8 | Columbus Crew | 34 | 10 | 16 | 8 | 46 | 41 | +5 | 46 | LXWX | 17 | 7 | 6 | 4 | 22 | 15 | 17 | 3 | 10 | 4 | 24 | 26 | ||
| 9 | 1 | Charlotte FC | 34 | 13 | 3 | 18 | 44 | 52 | -8 | 42 | LXWW | 17 | 10 | 1 | 6 | 28 | 16 | 17 | 3 | 2 | 12 | 16 | 36 | |
| 10 | 1 | New England Revolution | 34 | 10 | 12 | 12 | 47 | 50 | -3 | 42 | XWLL | 17 | 7 | 6 | 4 | 22 | 16 | 17 | 3 | 6 | 8 | 25 | 34 | |
| 11 | 2 | Atlanta United | 34 | 10 | 10 | 14 | 48 | 54 | -6 | 40 | LLOW | 17 | 8 | 5 | 4 | 31 | 24 | 17 | 2 | 5 | 10 | 17 | 30 | |
| 12 | Chicago Fire | 34 | 10 | 9 | 15 | 39 | 48 | -9 | 39 | XWLL | 17 | 6 | 5 | 6 | 18 | 17 | 17 | 4 | 4 | 9 | 21 | 31 | ||
| 13 | Toronto FC | 34 | 9 | 7 | 18 | 49 | 66 | -17 | 34 | LLLL | 17 | 7 | 3 | 7 | 30 | 29 | 17 | 2 | 4 | 11 | 19 | 37 | ||
| 14 | D.C. United | 34 | 7 | 6 | 21 | 36 | 71 | -35 | 27 | LLLL | 17 | 4 | 4 | 9 | 22 | 34 | 17 | 3 | 2 | 12 | 14 | 37 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 34 | 21 | 4 | 9 | 66 | 38 | +28 | 67 | LWWX | 17 | 13 | 2 | 2 | 39 | 15 | 17 | 8 | 2 | 7 | 27 | 23 | ||
| 2 | Austin FC | 34 | 16 | 8 | 10 | 65 | 49 | +16 | 56 | XLXW | 17 | 8 | 6 | 3 | 42 | 23 | 17 | 8 | 2 | 7 | 23 | 26 | ||
| 3 | FC Dallas | 34 | 14 | 11 | 9 | 48 | 37 | +11 | 53 | WLXW | 17 | 10 | 4 | 3 | 28 | 15 | 17 | 4 | 7 | 6 | 20 | 22 | ||
| 4 | 3 | LA Galaxy | 34 | 14 | 8 | 12 | 58 | 51 | +7 | 50 | WXWW | 17 | 8 | 4 | 5 | 35 | 25 | 17 | 6 | 4 | 7 | 23 | 26 | |
| 5 | 1 | Nashville | 34 | 13 | 11 | 10 | 52 | 41 | +11 | 50 | WLXX | 17 | 6 | 6 | 5 | 30 | 21 | 17 | 7 | 5 | 5 | 22 | 20 | |
| 6 | Minnesota United | 34 | 14 | 6 | 14 | 48 | 51 | -3 | 48 | WLLX | 17 | 8 | 5 | 4 | 27 | 20 | 17 | 6 | 1 | 10 | 21 | 31 | ||
| 7 | 1 | Real Salt Lake | 34 | 12 | 11 | 11 | 43 | 45 | -2 | 47 | WXLL | 17 | 9 | 5 | 3 | 27 | 15 | 17 | 3 | 6 | 8 | 16 | 30 | |
| 8 | 3 | Portland Timbers | 34 | 11 | 13 | 10 | 53 | 53 | +0 | 46 | LLXW | 17 | 8 | 6 | 3 | 28 | 19 | 17 | 3 | 7 | 7 | 25 | 34 | |
| 9 | Vancouver Whitecaps | 34 | 12 | 7 | 15 | 40 | 57 | -17 | 43 | LWWW | 17 | 10 | 3 | 4 | 25 | 20 | 17 | 2 | 4 | 11 | 15 | 37 | ||
| 10 | 1 | Colorado Rapids | 34 | 11 | 10 | 13 | 46 | 57 | -11 | 43 | XWLW | 17 | 10 | 5 | 2 | 29 | 15 | 17 | 1 | 5 | 11 | 17 | 42 | |
| 11 | 1 | Seattle Sounders | 34 | 12 | 5 | 17 | 47 | 46 | +1 | 41 | XLXL | 17 | 9 | 3 | 5 | 29 | 19 | 17 | 3 | 2 | 12 | 18 | 27 | |
| 12 | Sporting Kansas City | 34 | 11 | 7 | 16 | 42 | 54 | -12 | 40 | LWWW | 17 | 9 | 2 | 6 | 25 | 17 | 17 | 2 | 5 | 10 | 17 | 37 | ||
| 13 | Houston Dynamo | 34 | 10 | 6 | 18 | 43 | 56 | -13 | 36 | LWLW | 17 | 6 | 5 | 6 | 24 | 22 | 17 | 4 | 1 | 12 | 19 | 34 | ||
| 14 | San Jose Earthquakes | 34 | 8 | 11 | 15 | 52 | 69 | -17 | 35 | XWLX | 17 | 7 | 6 | 4 | 31 | 27 | 17 | 1 | 5 | 11 | 21 | 42 | ||
| Sunday, 9 October 2022 | |||||
| D.C. United | 2-5 | FC Cincinnati | |||
| FC Dallas | 2-1 | Sporting Kansas City | |||
| Houston Dynamo | 1-3 | LA Galaxy | |||
| New York Red Bulls | 2-0 | Charlotte FC | |||
| Chicago Fire | 1-1 | New England Revolution | |||
| Seattle Sounders | 2-2 | San Jose Earthquakes | |||
| Real Salt Lake | 3-1 | Portland Timbers | |||
| Orlando City | 2-1 | Columbus Crew | |||
| Philadelphia Union | 4-0 | Toronto FC | |||
| Minnesota United | 2-0 | Vancouver Whitecaps | |||
| Los Angeles | 0-1 | Nashville | |||
| Austin FC | 1-1 | Colorado Rapids | |||
| Atlanta United | 1-2 | New York City | |||
| Inter Miami | 1-3 | CF Montréal | |||
| 23 | Hany MUKHTAR (Nashville, 6p) | |
| 22 | +3 | Dániel GAZDAG (Philadelphia Union, 7p) |
| +1 | Sebastián DRIUSSI (Austin FC, 4p) | |
| 18 | +3 | BRENNER Souza (FC Cincinnati, 1p) |
| +1 | Javier HERNÁNDEZ (LA Galaxy, 3p) | |
| Jesús FERREIRA (FC Dallas) | ||
| +1 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 17 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 2p) |
| 16 | Cristian ARANGO (Los Angeles, 1p) | |
| +1 | Diego RUBIO (Colorado Rapids, 4p) | |
| +2 | Gonzalo HIGUAÍN (Inter Miami, 5p) | |
| 15 | Rommel QUIOTO (CF Montréal, 4p) | |
| 14 | Julián CARRANZA (Philadelphia Union, 2p) | |
| Lewis MORGAN (New York Red Bulls, 6p) | ||
| 13 | Valentín CASTELLANOS (New York City, 5p) | |
| +3 | Sebastián FERREIRA (Houston Dynamo, 2p) | |
| +1 | Mikael UHRE (Philadelphia Union) | |
| 12 | +1 | Carlos VELA (Los Angeles, 4p) |
| Taxiarchis FOUNTAS (D.C. United) | ||
| 11 | +1 | Dejan JOVELJIĆ (LA Galaxy, 2p) |
| +1 | Ercan KARA (Orlando City, 1p) | |
| +1 | Leonardo CAMPANA (Inter Miami) |
