| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 174 | 503 | 2.89 | 81 | 46.55% | 36 | 20.69% | 57 | 32.76% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Memphis 901 | 12 | 9 | 1 | 2 | 27 | 12 | +15 | 28 | WWWW | 7 | 5 | 0 | 2 | 18 | 10 | 5 | 4 | 1 | 0 | 9 | 2 | |
| 2 | 1 | Louisville City | 13 | 8 | 3 | 2 | 27 | 11 | +16 | 27 | WLLW | 6 | 4 | 1 | 1 | 10 | 4 | 7 | 4 | 2 | 1 | 17 | 7 | |
| 3 | Detroit City | 13 | 7 | 4 | 2 | 22 | 12 | +10 | 25 | XWXW | 7 | 5 | 2 | 0 | 13 | 5 | 6 | 2 | 2 | 2 | 9 | 7 | ||
| 4 | Pittsburgh Riverhounds | 13 | 7 | 3 | 3 | 22 | 14 | +8 | 24 | XXLW | 6 | 5 | 1 | 0 | 11 | 2 | 7 | 2 | 2 | 3 | 11 | 12 | ||
| 5 | Tampa Bay Rowdies | 13 | 5 | 5 | 3 | 23 | 14 | +9 | 20 | XWWL | 6 | 3 | 1 | 2 | 11 | 7 | 7 | 2 | 4 | 1 | 12 | 7 | ||
| 6 | Miami FC | 14 | 5 | 5 | 4 | 16 | 12 | +4 | 20 | OXWX | 7 | 2 | 3 | 2 | 8 | 7 | 7 | 3 | 2 | 2 | 8 | 5 | ||
| 7 | Indy Eleven | 12 | 6 | 2 | 4 | 18 | 15 | +3 | 20 | WLWL | 6 | 4 | 1 | 1 | 10 | 5 | 6 | 2 | 1 | 3 | 8 | 10 | ||
| 8 | Birmingham Legion | 13 | 5 | 4 | 4 | 11 | 12 | -1 | 19 | WWOL | 7 | 2 | 4 | 1 | 5 | 5 | 6 | 3 | 0 | 3 | 6 | 7 | ||
| 9 | FC Tulsa | 14 | 4 | 2 | 8 | 19 | 29 | -10 | 14 | OXLL | 8 | 4 | 2 | 2 | 14 | 11 | 6 | 0 | 0 | 6 | 5 | 18 | ||
| 10 | 1 | Hartford Athletic | 11 | 2 | 2 | 7 | 11 | 17 | -6 | 8 | XLWW | 5 | 2 | 0 | 3 | 7 | 8 | 6 | 0 | 2 | 4 | 4 | 9 | |
| 11 | 1 | Loudoun United | 12 | 2 | 2 | 8 | 10 | 22 | -12 | 8 | XLLL | 6 | 1 | 1 | 4 | 4 | 11 | 6 | 1 | 1 | 4 | 6 | 11 | |
| 12 | Atlanta United 2 | 13 | 2 | 1 | 10 | 13 | 33 | -20 | 7 | LLOL | 7 | 1 | 1 | 5 | 7 | 17 | 6 | 1 | 0 | 5 | 6 | 16 | ||
| 13 | 1 | New York Red Bulls 2 | 13 | 1 | 2 | 10 | 9 | 24 | -15 | 5 | XLLL | 7 | 0 | 2 | 5 | 4 | 12 | 6 | 1 | 0 | 5 | 5 | 12 | |
| 14 | 1 | Charleston Battery | 12 | 1 | 2 | 9 | 10 | 27 | -17 | 5 | LXLL | 7 | 1 | 1 | 5 | 6 | 15 | 5 | 0 | 1 | 4 | 4 | 12 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Colorado Springs | 11 | 9 | 0 | 2 | 24 | 12 | +12 | 27 | WLWW | 5 | 4 | 0 | 1 | 10 | 5 | 6 | 5 | 0 | 1 | 14 | 7 | |
| 2 | 1 | San Antonio | 12 | 9 | 0 | 3 | 19 | 10 | +9 | 27 | LWWL | 4 | 3 | 0 | 1 | 8 | 2 | 8 | 6 | 0 | 2 | 11 | 8 | |
| 3 | 3 | New Mexico United | 12 | 6 | 4 | 2 | 21 | 9 | +12 | 22 | WWWW | 6 | 2 | 3 | 1 | 13 | 5 | 6 | 4 | 1 | 1 | 8 | 4 | |
| 4 | 1 | San Diego Loyal | 13 | 6 | 4 | 3 | 27 | 23 | +4 | 22 | XXLX | 5 | 4 | 0 | 1 | 13 | 9 | 8 | 2 | 4 | 2 | 14 | 14 | |
| 5 | El Paso Locomotive | 15 | 6 | 3 | 6 | 29 | 21 | +8 | 21 | XWXW | 8 | 4 | 2 | 2 | 20 | 10 | 7 | 2 | 1 | 4 | 9 | 11 | ||
| 6 | 2 | Phoenix Rising | 13 | 7 | 0 | 6 | 21 | 26 | -5 | 21 | LWLL | 8 | 5 | 0 | 3 | 16 | 13 | 5 | 2 | 0 | 3 | 5 | 13 | |
| 7 | Sacramento Republic | 12 | 5 | 4 | 3 | 13 | 11 | +2 | 19 | WXLW | 6 | 4 | 2 | 0 | 9 | 4 | 6 | 1 | 2 | 3 | 4 | 7 | ||
| 8 | 4 | Oakland Roots | 15 | 4 | 7 | 4 | 22 | 21 | +1 | 19 | WWXW | 8 | 3 | 3 | 2 | 13 | 12 | 7 | 1 | 4 | 2 | 9 | 9 | |
| 9 | RGV Toros | 14 | 6 | 0 | 8 | 20 | 22 | -2 | 18 | LWLW | 8 | 3 | 0 | 5 | 10 | 12 | 6 | 3 | 0 | 3 | 10 | 10 | ||
| 10 | LA Galaxy 2 | 14 | 5 | 3 | 6 | 19 | 25 | -6 | 18 | WXLL | 6 | 4 | 1 | 1 | 14 | 8 | 8 | 1 | 2 | 5 | 5 | 17 | ||
| 11 | 3 | Las Vegas Lights | 14 | 4 | 4 | 6 | 15 | 20 | -5 | 16 | LLOX | 7 | 2 | 2 | 3 | 7 | 8 | 7 | 2 | 2 | 3 | 8 | 12 | |
| 12 | 1 | Orange County SC | 13 | 3 | 5 | 5 | 20 | 20 | +0 | 14 | LLOX | 7 | 2 | 3 | 2 | 13 | 10 | 6 | 1 | 2 | 3 | 7 | 10 | |
| 13 | Monterey Bay | 12 | 4 | 0 | 8 | 15 | 29 | -14 | 12 | LWWL | 4 | 2 | 0 | 2 | 6 | 6 | 8 | 2 | 0 | 6 | 9 | 23 | ||
| 10 | +2 | Óttar KARLSSON (Oakland Roots, 4p) |
| 8 | Kyle VASSELL (San Diego Loyal, 1p) | |
| 7 | +1 | Milan ILOSKI (Orange County SC) |
| +2 | Phillip GOODRUM (Memphis 901) | |
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| Wilson HARRIS (Louisville City) | ||
| 6 | +1 | STÉFANO Souza (Indy Eleven) |
| +1 | Erick TORRES (Orange County SC, 2p) | |
| Danny TREJO (Las Vegas Lights) | ||
| Jake LACAVA (Tampa Bay Rowdies) | ||
| Dane KELLY (Pittsburgh Riverhounds) | ||
| 5 | +1 | Michee NGALINA (Colorado Springs) |
| +1 | Laurent KISSIEDOU (Memphis 901) | |
| Dylan MARES (El Paso Locomotive) | ||
| Jerome 'J.J.' WILLIAMS (FC Tulsa) | ||
| +1 | Albert DIKWA (Pittsburgh Riverhounds) | |
| +1 | RODRIGO BANDEIRA da Costa (FC Tulsa) | |
| +1 | Elvis AMOH (Colorado Springs) | |
| Luis SEIJAS (Phoenix Rising) | ||
| Antoine HOPPENOT (Detroit City) | ||
| Greg HURST (Phoenix Rising) |
| Wednesday, 1 June 2022 | |||||
| FC Tulsa | 1-1 | Tampa Bay Rowdies | |||
| 83 | Rodrigo Bandeira | 17 | Wyke | ||
| Atlanta United 2 | 3-4 | RGV Toros | |||
| 45(p) | Raimar | 22 | Ycaza | ||
| 50 | Mertz | 26 | Hernández | ||
| 65 | Mertz | 77 | Coronado | ||
| 90 | Coronado | ||||
| Oakland Roots | 3-2 | Orange County SC | |||
| 9 | Karlsson | 32(p) | Torres | ||
| 90 | Azocár | 65 | Skendi | ||
| 90 | Karlsson | ||||
| Thursday, 2 June 2022 | |||||
| New York Red Bulls 2 | 2-2 | San Diego Loyal | |||
| 16 | Clark | 50 | Amang | ||
| 24 | Williams | 88 | Amang | ||
| Friday, 3 June 2022 | |||||
| Colorado Springs | 3-0 | Las Vegas Lights | |||
| 26 | Amoh | ||||
| 57 | Ngalina | ||||
| 60 | Mahoney | ||||
| Saturday, 4 June 2022 | |||||
| Charleston Battery | 3-4 | Indy Eleven | |||
| 35 | Williams | 21 | Stéfano | ||
| 89 | Johnson | 25 | Arteaga | ||
| 90 | Williams | 28 | Arteaga | ||
| 37 | Arteaga | ||||
| Pittsburgh Riverhounds | 1-1 | Detroit City | |||
| 30 | Dikwa | 70 | Rodriguez | ||
| Orange County SC | 1-2 | New Mexico United | |||
| 90 | Iloski | 18(p) | Portillo | ||
| 32 | Wehan | ||||
| Phoenix Rising | 0-1 | Birmingham Legion | |||
| 58 | Kasim | ||||
| Sacramento Republic | 1-0 | San Antonio | |||
| 37 | Martínez | ||||
| FC Tulsa | 0-0 | Miami FC | |||
| RGV Toros | 0-1 | LA Galaxy 2 | |||
| 48 | Judd | ||||
| El Paso Locomotive | 1-1 | Hartford Athletic | |||
| 56 | Abarca | 68 | Vassell | ||
| Memphis 901 | 5-2 | Atlanta United 2 | |||
| 24 | Kissiedou | 18 | Mertz | ||
| 26 | Goodrum | 46 | Sullins | ||
| 30 | Goodrum | ||||
| 70 | Molloy | ||||
| 82 | Lucas Turci | ||||
| Monterey Bay | 0-2 | Oakland Roots | |||
| 21 | Rito | ||||
| 90 | Formella | ||||