| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 415 | 1,198 | 2.88 | 191 | 46.02% | 90 | 21.69% | 134 | 32.29% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 31 | 19 | 6 | 6 | 60 | 26 | +34 | 63 | LWOX | 15 | 11 | 2 | 2 | 34 | 12 | 16 | 8 | 4 | 4 | 26 | 14 | ||
| 2 | Memphis 901 | 30 | 19 | 4 | 7 | 60 | 29 | +31 | 61 | WWWX | 15 | 10 | 0 | 5 | 36 | 19 | 15 | 9 | 4 | 2 | 24 | 10 | ||
| 3 | Tampa Bay Rowdies | 30 | 16 | 7 | 7 | 59 | 31 | +28 | 55 | XLLW | 14 | 9 | 3 | 2 | 29 | 12 | 16 | 7 | 4 | 5 | 30 | 19 | ||
| 4 | Birmingham Legion | 31 | 16 | 7 | 8 | 51 | 32 | +19 | 55 | XWLX | 15 | 8 | 4 | 3 | 25 | 12 | 16 | 8 | 3 | 5 | 26 | 20 | ||
| 5 | Pittsburgh Riverhounds | 31 | 15 | 8 | 8 | 46 | 35 | +11 | 53 | XLOW | 15 | 8 | 5 | 2 | 22 | 13 | 16 | 7 | 3 | 6 | 24 | 22 | ||
| 6 | Detroit City | 31 | 13 | 12 | 6 | 39 | 27 | +12 | 51 | XOWW | 16 | 6 | 8 | 2 | 21 | 15 | 15 | 7 | 4 | 4 | 18 | 12 | ||
| 7 | Miami FC | 31 | 13 | 10 | 8 | 43 | 29 | +14 | 49 | OXWX | 16 | 4 | 7 | 5 | 17 | 18 | 15 | 9 | 3 | 3 | 26 | 11 | ||
| 8 | FC Tulsa | 31 | 10 | 6 | 15 | 42 | 53 | -11 | 36 | XLXL | 15 | 8 | 3 | 4 | 25 | 20 | 16 | 2 | 3 | 11 | 17 | 33 | ||
| 9 | 1 | Indy Eleven | 30 | 10 | 5 | 15 | 33 | 47 | -14 | 35 | WLWO | 15 | 8 | 2 | 5 | 20 | 17 | 15 | 2 | 3 | 10 | 13 | 30 | |
| 10 | 1 | Hartford Athletic | 31 | 9 | 6 | 16 | 39 | 49 | -10 | 33 | LWWW | 15 | 6 | 1 | 8 | 21 | 22 | 16 | 3 | 5 | 8 | 18 | 27 | |
| 11 | Loudoun United | 31 | 8 | 3 | 20 | 35 | 61 | -26 | 27 | LWLL | 16 | 6 | 2 | 8 | 22 | 26 | 15 | 2 | 1 | 12 | 13 | 35 | ||
| 12 | Charleston Battery | 31 | 6 | 6 | 19 | 36 | 66 | -30 | 24 | LLWW | 16 | 5 | 1 | 10 | 22 | 34 | 15 | 1 | 5 | 9 | 14 | 32 | ||
| 13 | Atlanta United 2 | 31 | 5 | 5 | 21 | 35 | 80 | -45 | 20 | XLWL | 16 | 3 | 4 | 9 | 18 | 35 | 15 | 2 | 1 | 12 | 17 | 45 | ||
| 14 | New York Red Bulls 2 | 31 | 3 | 6 | 22 | 22 | 68 | -46 | 15 | OLLL | 17 | 2 | 5 | 10 | 14 | 33 | 14 | 1 | 1 | 12 | 8 | 35 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Antonio | 31 | 22 | 4 | 5 | 49 | 23 | +26 | 70 | WWXW | 16 | 11 | 4 | 1 | 29 | 9 | 15 | 11 | 0 | 4 | 20 | 14 | ||
| 2 | San Diego Loyal | 31 | 18 | 4 | 9 | 63 | 46 | +17 | 58 | WWLL | 16 | 12 | 0 | 4 | 37 | 21 | 15 | 6 | 4 | 5 | 26 | 25 | ||
| 3 | Colorado Springs | 32 | 16 | 4 | 12 | 55 | 50 | +5 | 52 | XLLL | 17 | 10 | 3 | 4 | 35 | 24 | 15 | 6 | 1 | 8 | 20 | 26 | ||
| 4 | Sacramento Republic | 30 | 14 | 7 | 9 | 43 | 30 | +13 | 49 | LWWL | 14 | 9 | 4 | 1 | 27 | 9 | 16 | 5 | 3 | 8 | 16 | 21 | ||
| 5 | El Paso Locomotive | 31 | 12 | 7 | 12 | 52 | 44 | +8 | 43 | WLWW | 15 | 7 | 2 | 6 | 30 | 18 | 16 | 5 | 5 | 6 | 22 | 26 | ||
| 6 | New Mexico United | 30 | 11 | 10 | 9 | 41 | 35 | +6 | 43 | XLLL | 15 | 4 | 5 | 6 | 20 | 18 | 15 | 7 | 5 | 3 | 21 | 17 | ||
| 7 | RGV Toros | 30 | 12 | 6 | 12 | 43 | 35 | +8 | 42 | WWWW | 14 | 6 | 2 | 6 | 15 | 14 | 16 | 6 | 4 | 6 | 28 | 21 | ||
| 8 | Oakland Roots | 31 | 9 | 13 | 9 | 45 | 41 | +4 | 40 | XWWL | 16 | 6 | 5 | 5 | 24 | 21 | 15 | 3 | 8 | 4 | 21 | 20 | ||
| 9 | Monterey Bay | 31 | 12 | 4 | 15 | 40 | 51 | -11 | 40 | LOXW | 16 | 8 | 3 | 5 | 26 | 18 | 15 | 4 | 1 | 10 | 14 | 33 | ||
| 10 | Las Vegas Lights | 31 | 11 | 7 | 13 | 36 | 47 | -11 | 40 | WLLL | 15 | 6 | 2 | 7 | 20 | 21 | 16 | 5 | 5 | 6 | 16 | 26 | ||
| 11 | LA Galaxy 2 | 30 | 10 | 6 | 14 | 47 | 56 | -9 | 36 | LLLW | 14 | 6 | 3 | 5 | 29 | 28 | 16 | 4 | 3 | 9 | 18 | 28 | ||
| 12 | Phoenix Rising | 30 | 9 | 6 | 15 | 40 | 54 | -14 | 33 | XLLL | 15 | 7 | 3 | 5 | 24 | 19 | 15 | 2 | 3 | 10 | 16 | 35 | ||
| 13 | Orange County SC | 31 | 7 | 11 | 13 | 44 | 53 | -9 | 32 | XLWL | 16 | 5 | 7 | 4 | 26 | 22 | 15 | 2 | 4 | 9 | 18 | 31 | ||
| 21 | +1 | Milan ILOSKI (Orange County SC) |
| 19 | Phillip GOODRUM (Memphis 901) | |
| 17 | +1 | Óttar KARLSSON (Oakland Roots, 7p) |
| 16 | +1 | Leonardo FERNANDES (Tampa Bay Rowdies, 5p) |
| Hadji BARRY (Colorado Springs, 3p) | ||
| 15 | Luis SOLIGNAC (El Paso Locomotive, 1p) | |
| 14 | +1 | Kyle VASSELL (San Diego Loyal, 1p) |
| Augustine WILLIAMS (Charleston Battery, 2p) | ||
| 13 | +3 | Danny TREJO (Las Vegas Lights) |
| +1 | Elvis AMOH (Colorado Springs) | |
| Enzo MARTÍNEZ (Birmingham Legion) | ||
| +1 | Wilson HARRIS (Louisville City, 1p) | |
| 12 | Russell CICERONE (Pittsburgh Riverhounds) | |
| Preston JUDD (LA Galaxy 2) | ||
| 11 | Jerome 'J.J.' WILLIAMS (Phoenix Rising) | |
| +1 | Albert DIKWA (Pittsburgh Riverhounds) | |
| Jake LACAVA (Tampa Bay Rowdies) | ||
| 10 | STÉFANO Souza (Indy Eleven, 1p) | |
| Jackson CONWAY (Atlanta United 2) | ||
| Dylan MARES (El Paso Locomotive) | ||
| Kyle MURPHY (Miami FC, 2p) | ||
| Cameron DUNBAR (LA Galaxy 2, 3p) | ||
| +1 | Samuel ADENIRAN (San Antonio) | |
| Enoch MUSHAGALUSA (Louisville City) | ||
| +1 | Cal JENNINGS (Las Vegas Lights, 1p) |
| Friday, 23 September 2022 | |||||
| Charleston Battery | 0-3 | RGV Toros | |||
| 55 | Pinzón | ||||
| 76 | Pinzón | ||||
| 80 | Torres | ||||
| Tampa Bay Rowdies | 1-1 | Birmingham Legion | |||
| 17 | Fernandes | 10 | Marlon | ||
| Louisville City | 1-2 | Memphis 901 | |||
| 47 | Harris | 61 | Dodson | ||
| 90 | Smith | ||||
| Saturday, 24 September 2022 | |||||
| Pittsburgh Riverhounds | 1-1 | Orange County SC | |||
| 4 | Dikwa | 90 | Iloski | ||
| San Antonio | 1-0 | Sacramento Republic | |||
| 17 | Adeniran | ||||
| Colorado Springs | 1-1 | Oakland Roots | |||
| 1 | Amoh | 57(p) | Karlsson | ||
| Miami FC | 0-0 | Monterey Bay | |||
| Las Vegas Lights | 1-2 | San Diego Loyal | |||
| 71 | Trejo | 1 | Vassell | ||
| 4 | Martin | ||||
| Detroit City | 2-2 | FC Tulsa | |||
| 47 | Matthews | 67 | Suárez | ||
| 75 | Bryant | 69 | Bird | ||
| Sunday, 25 September 2022 | |||||
| Indy Eleven | 1-0 | Loudoun United | |||
| 68(p) | Ayoze | ||||
| Tuesday, 27 September 2022 | |||||
| Las Vegas Lights | 4-0 | Monterey Bay | |||
| 41 | Trejo | ||||
| 45 | Keinan | ||||
| 67 | Jennings | ||||
| 82 | Trejo | ||||