| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 66 | 181 | 2.74 | 32 | 48.48% | 11 | 16.67% | 23 | 34.85% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Pittsburgh Riverhounds | 5 | 4 | 1 | 0 | 12 | 5 | +7 | 13 | WWXW | 2 | 2 | 0 | 0 | 4 | 1 | 3 | 2 | 1 | 0 | 8 | 4 | |
| 2 | 1 | Louisville City | 5 | 3 | 2 | 0 | 6 | 1 | +5 | 11 | OXWW | 3 | 2 | 1 | 0 | 4 | 1 | 2 | 1 | 1 | 0 | 2 | 0 | |
| 3 | Tampa Bay Rowdies | 6 | 2 | 3 | 1 | 7 | 3 | +4 | 9 | LOXW | 3 | 1 | 1 | 1 | 3 | 2 | 3 | 1 | 2 | 0 | 4 | 1 | ||
| 4 | FC Tulsa | 6 | 3 | 0 | 3 | 11 | 10 | +1 | 9 | LWLW | 4 | 3 | 0 | 1 | 10 | 7 | 2 | 0 | 0 | 2 | 1 | 3 | ||
| 5 | 3 | Detroit City | 5 | 2 | 2 | 1 | 7 | 3 | +4 | 8 | WXXW | 3 | 1 | 2 | 0 | 3 | 2 | 2 | 1 | 0 | 1 | 4 | 1 | |
| 6 | 1 | Loudoun United | 4 | 2 | 1 | 1 | 4 | 2 | +2 | 7 | LOWW | 1 | 1 | 0 | 0 | 1 | 0 | 3 | 1 | 1 | 1 | 3 | 2 | |
| 7 | 2 | Miami FC | 5 | 2 | 1 | 2 | 4 | 4 | +0 | 7 | WLOL | 3 | 1 | 1 | 1 | 3 | 2 | 2 | 1 | 0 | 1 | 1 | 2 | |
| 8 | 2 | Memphis 901 | 4 | 2 | 1 | 1 | 4 | 5 | -1 | 7 | XWWL | 2 | 1 | 0 | 1 | 2 | 4 | 2 | 1 | 1 | 0 | 2 | 1 | |
| 9 | 2 | Atlanta United 2 | 6 | 2 | 0 | 4 | 6 | 11 | -5 | 6 | LWWL | 4 | 1 | 0 | 3 | 4 | 9 | 2 | 1 | 0 | 1 | 2 | 2 | |
| 10 | 2 | Indy Eleven | 5 | 1 | 2 | 2 | 4 | 6 | -2 | 5 | WXXL | 1 | 0 | 1 | 0 | 1 | 1 | 4 | 1 | 1 | 2 | 3 | 5 | |
| 11 | 1 | Charleston Battery | 5 | 1 | 0 | 4 | 4 | 11 | -7 | 3 | LLLL | 2 | 1 | 0 | 1 | 2 | 2 | 3 | 0 | 0 | 3 | 2 | 9 | |
| 12 | 1 | New York Red Bulls 2 | 5 | 1 | 0 | 4 | 3 | 10 | -7 | 3 | LLLW | 2 | 0 | 0 | 2 | 0 | 5 | 3 | 1 | 0 | 2 | 3 | 5 | |
| 13 | Birmingham Legion | 4 | 0 | 2 | 2 | 2 | 6 | -4 | 2 | OLLX | 3 | 0 | 2 | 1 | 1 | 3 | 1 | 0 | 0 | 1 | 1 | 3 | ||
| 14 | Hartford Athletic | 3 | 0 | 1 | 2 | 3 | 5 | -2 | 1 | LXL- | 1 | 0 | 0 | 1 | 1 | 2 | 2 | 0 | 1 | 1 | 2 | 3 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | San Diego Loyal | 6 | 5 | 0 | 1 | 14 | 7 | +7 | 15 | WWWL | 4 | 4 | 0 | 0 | 11 | 4 | 2 | 1 | 0 | 1 | 3 | 3 | |
| 2 | 1 | Colorado Springs | 5 | 5 | 0 | 0 | 10 | 4 | +6 | 15 | WWWW | 2 | 2 | 0 | 0 | 3 | 1 | 3 | 3 | 0 | 0 | 7 | 3 | |
| 3 | 1 | San Antonio | 5 | 4 | 0 | 1 | 6 | 4 | +2 | 12 | WLWW | 2 | 1 | 0 | 1 | 1 | 2 | 3 | 3 | 0 | 0 | 5 | 2 | |
| 4 | 3 | Phoenix Rising | 5 | 3 | 0 | 2 | 12 | 8 | +4 | 9 | WWLL | 3 | 2 | 0 | 1 | 9 | 6 | 2 | 1 | 0 | 1 | 3 | 2 | |
| 5 | 2 | Sacramento Republic | 4 | 3 | 0 | 1 | 7 | 5 | +2 | 9 | WWLW | 3 | 3 | 0 | 0 | 7 | 3 | 1 | 0 | 0 | 1 | 0 | 2 | |
| 6 | 1 | Las Vegas Lights | 6 | 3 | 0 | 3 | 11 | 12 | -1 | 9 | LWLW | 3 | 1 | 0 | 2 | 4 | 5 | 3 | 2 | 0 | 1 | 7 | 7 | |
| 7 | 1 | New Mexico United | 4 | 2 | 2 | 0 | 7 | 4 | +3 | 8 | XXWW | 3 | 1 | 2 | 0 | 5 | 3 | 1 | 1 | 0 | 0 | 2 | 1 | |
| 8 | Orange County SC | 4 | 1 | 1 | 2 | 4 | 5 | -1 | 4 | LXWL | 2 | 1 | 0 | 1 | 2 | 2 | 2 | 0 | 1 | 1 | 2 | 3 | ||
| 9 | LA Galaxy 2 | 5 | 1 | 1 | 3 | 5 | 8 | -3 | 4 | LXWL | 2 | 1 | 0 | 1 | 2 | 2 | 3 | 0 | 1 | 2 | 3 | 6 | ||
| 10 | 3 | El Paso Locomotive | 5 | 1 | 0 | 4 | 13 | 13 | +0 | 3 | WLLL | 3 | 1 | 0 | 2 | 10 | 7 | 2 | 0 | 0 | 2 | 3 | 6 | |
| 11 | 1 | RGV Toros | 5 | 1 | 0 | 4 | 4 | 7 | -3 | 3 | LLLL | 3 | 1 | 0 | 2 | 3 | 4 | 2 | 0 | 0 | 2 | 1 | 3 | |
| 12 | 1 | Monterey Bay | 5 | 1 | 0 | 4 | 6 | 14 | -8 | 3 | LLWL | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 4 | 6 | 14 | |
| 13 | 1 | Oakland Roots | 5 | 0 | 2 | 3 | 5 | 8 | -3 | 2 | OXLL | 2 | 0 | 1 | 1 | 2 | 3 | 3 | 0 | 1 | 2 | 3 | 5 | |
| 5 | Danny TREJO (Las Vegas Lights) | |
| 4 | +3 | Kyle VASSELL (San Diego Loyal) |
| +2 | Albert DIKWA (Pittsburgh Riverhounds) | |
| +1 | Dane KELLY (Pittsburgh Riverhounds) | |
| 3 | +2 | STÉFANO Souza (Indy Eleven) |
| Michee NGALINA (Colorado Springs) | ||
| Jackson CONWAY (Atlanta United 2) | ||
| +3 | Aarón GÓMEZ (El Paso Locomotive, 1p) | |
| +1 | Dylan MARES (El Paso Locomotive) | |
| +1 | Jerome 'J.J.' WILLIAMS (FC Tulsa) | |
| +1 | RODRIGO BANDEIRA da Costa (FC Tulsa) | |
| Jake LACAVA (Tampa Bay Rowdies) | ||
| Chase BOONE (Monterey Bay) | ||
| +2 | Luis SEIJAS (Phoenix Rising) | |
| Neco BRETT (New Mexico United) | ||
| +1 | Frank LÓPEZ (RGV Toros) | |
| +1 | Cal JENNINGS (Las Vegas Lights) |
| Sunday, 3 April 2022 | |||||
| San Diego Loyal | 3-2 | El Paso Locomotive | |||
| 21 | Vassell | 26 | Brockbank | ||
| 40 | Moshobane | 87 | Gómez | ||
| 66 | Amang | ||||
| Saturday, 9 April 2022 | |||||
| Tampa Bay Rowdies | 0-1 | Miami FC | |||
| 51 | Da Silva | ||||
| Orange County SC | 0-1 | San Antonio | |||
| 60 | Collier | ||||
| Phoenix Rising | 3-1 | LA Galaxy 2 | |||
| 31 | Seijas | 68 | Cabral | ||
| 42 | Seijas | ||||
| 90 | Epps | ||||
| FC Tulsa | 3-4 | Pittsburgh Riverhounds | |||
| 19(og) | Silva | 6 | Dikwa | ||
| 80 | Williams | 14 | Dixon | ||
| 85 | Rodrigo Bandeira | 47 | Kelly | ||
| 59 | Dikwa | ||||
| RGV Toros | 1-2 | Indy Eleven | |||
| 83 | López | 69 | Stéfano | ||
| 78 | Stéfano | ||||
| Las Vegas Lights | 2-3 | Colorado Springs | |||
| 43(og) | Mahoney | 22 | Amoh | ||
| 61 | Jennings | 70 | Zandi | ||
| 75 | Lindley | ||||
| Atlanta United 2 | 0-4 | Detroit City | |||
| 23 | Carroll | ||||
| 33 | Hoppenot | ||||
| 42 | Botello | ||||
| 78 | Bryant | ||||
| El Paso Locomotive | 5-0 | Monterey Bay | |||
| 19 | Fox | ||||
| 35(p) | Gómez | ||||
| 47 | Gómez | ||||
| 51 | Luna | ||||
| 75 | Mares | ||||
| San Diego Loyal | 4-1 | Charleston Battery | |||
| 11 | Moshobane | 28 | Cichero | ||
| 23(og) | Kuzminsky | ||||
| 45 | Vassell | ||||
| 75 | Vassell | ||||