| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 263 | 771 | 2.93 | 123 | 46.77% | 55 | 20.91% | 85 | 32.32% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Louisville City | 19 | 13 | 3 | 3 | 42 | 15 | +27 | 42 | WWWW | 9 | 7 | 1 | 1 | 21 | 6 | 10 | 6 | 2 | 2 | 21 | 9 | ||
| 2 | 1 | Tampa Bay Rowdies | 20 | 11 | 6 | 3 | 41 | 21 | +20 | 39 | WWWW | 9 | 5 | 2 | 2 | 15 | 8 | 11 | 6 | 4 | 1 | 26 | 13 | |
| 3 | 1 | Memphis 901 | 19 | 12 | 2 | 5 | 36 | 19 | +17 | 38 | LWLW | 11 | 8 | 0 | 3 | 26 | 13 | 8 | 4 | 2 | 2 | 10 | 6 | |
| 4 | Pittsburgh Riverhounds | 20 | 10 | 4 | 6 | 33 | 25 | +8 | 34 | XWWW | 9 | 7 | 1 | 1 | 18 | 8 | 11 | 3 | 3 | 5 | 15 | 17 | ||
| 5 | Detroit City | 20 | 9 | 7 | 4 | 26 | 18 | +8 | 34 | OWXW | 10 | 5 | 4 | 1 | 15 | 9 | 10 | 4 | 3 | 3 | 11 | 9 | ||
| 6 | Birmingham Legion | 19 | 9 | 5 | 5 | 22 | 17 | +5 | 32 | WWXL | 8 | 3 | 4 | 1 | 6 | 5 | 11 | 6 | 1 | 4 | 16 | 12 | ||
| 7 | Miami FC | 21 | 7 | 7 | 7 | 22 | 22 | +0 | 28 | OWLW | 11 | 3 | 4 | 4 | 12 | 13 | 10 | 4 | 3 | 3 | 10 | 9 | ||
| 8 | FC Tulsa | 21 | 6 | 4 | 11 | 27 | 39 | -12 | 22 | LWXL | 11 | 6 | 2 | 3 | 19 | 15 | 10 | 0 | 2 | 8 | 8 | 24 | ||
| 9 | Indy Eleven | 19 | 6 | 3 | 10 | 22 | 29 | -7 | 21 | LLLL | 8 | 4 | 1 | 3 | 10 | 7 | 11 | 2 | 2 | 7 | 12 | 22 | ||
| 10 | Hartford Athletic | 19 | 4 | 4 | 11 | 21 | 30 | -9 | 16 | LLXW | 9 | 3 | 1 | 5 | 12 | 14 | 10 | 1 | 3 | 6 | 9 | 16 | ||
| 11 | Loudoun United | 18 | 4 | 3 | 11 | 19 | 36 | -17 | 15 | LXLW | 10 | 3 | 2 | 5 | 12 | 20 | 8 | 1 | 1 | 6 | 7 | 16 | ||
| 12 | Atlanta United 2 | 21 | 4 | 3 | 14 | 26 | 54 | -28 | 15 | LLXX | 11 | 2 | 3 | 6 | 14 | 25 | 10 | 2 | 0 | 8 | 12 | 29 | ||
| 13 | Charleston Battery | 20 | 3 | 3 | 14 | 21 | 41 | -20 | 12 | WLLL | 11 | 3 | 1 | 7 | 15 | 23 | 9 | 0 | 2 | 7 | 6 | 18 | ||
| 14 | New York Red Bulls 2 | 19 | 2 | 3 | 14 | 10 | 39 | -29 | 9 | WLLL | 10 | 1 | 3 | 6 | 5 | 15 | 9 | 1 | 0 | 8 | 5 | 24 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | San Antonio | 18 | 14 | 1 | 3 | 33 | 14 | +19 | 43 | WWWW | 8 | 6 | 1 | 1 | 18 | 4 | 10 | 8 | 0 | 2 | 15 | 10 | ||
| 2 | Colorado Springs | 19 | 13 | 0 | 6 | 40 | 25 | +15 | 39 | WLLW | 10 | 7 | 0 | 3 | 23 | 14 | 9 | 6 | 0 | 3 | 17 | 11 | ||
| 3 | 2 | New Mexico United | 19 | 9 | 7 | 3 | 29 | 16 | +13 | 34 | XWXW | 10 | 3 | 5 | 2 | 16 | 9 | 9 | 6 | 2 | 1 | 13 | 7 | |
| 4 | 1 | San Diego Loyal | 19 | 10 | 4 | 5 | 41 | 33 | +8 | 34 | LWWW | 10 | 7 | 0 | 3 | 24 | 17 | 9 | 3 | 4 | 2 | 17 | 16 | |
| 5 | 1 | El Paso Locomotive | 22 | 9 | 6 | 7 | 39 | 28 | +11 | 33 | LWXO | 10 | 6 | 2 | 2 | 26 | 10 | 12 | 3 | 4 | 5 | 13 | 18 | |
| 6 | LA Galaxy 2 | 21 | 9 | 3 | 9 | 36 | 38 | -2 | 30 | LWWW | 9 | 6 | 1 | 2 | 21 | 14 | 12 | 3 | 2 | 7 | 15 | 24 | ||
| 7 | Sacramento Republic | 18 | 8 | 5 | 5 | 22 | 19 | +3 | 29 | LXLW | 9 | 5 | 3 | 1 | 14 | 8 | 9 | 3 | 2 | 4 | 8 | 11 | ||
| 8 | Oakland Roots | 22 | 6 | 10 | 6 | 37 | 33 | +4 | 28 | WXLW | 12 | 5 | 4 | 3 | 23 | 17 | 10 | 1 | 6 | 3 | 14 | 16 | ||
| 9 | Las Vegas Lights | 18 | 7 | 4 | 7 | 23 | 24 | -1 | 25 | LWWW | 10 | 4 | 2 | 4 | 13 | 11 | 8 | 3 | 2 | 3 | 10 | 13 | ||
| 10 | RGV Toros | 19 | 7 | 3 | 9 | 24 | 26 | -2 | 24 | XLOW | 10 | 4 | 1 | 5 | 11 | 12 | 9 | 3 | 2 | 4 | 13 | 14 | ||
| 11 | Phoenix Rising | 18 | 7 | 1 | 10 | 29 | 39 | -10 | 22 | LXLL | 10 | 5 | 1 | 4 | 18 | 16 | 8 | 2 | 0 | 6 | 11 | 23 | ||
| 12 | Orange County SC | 20 | 4 | 7 | 9 | 27 | 33 | -6 | 19 | OLXL | 10 | 3 | 4 | 3 | 16 | 13 | 10 | 1 | 3 | 6 | 11 | 20 | ||
| 13 | Monterey Bay | 18 | 5 | 2 | 11 | 23 | 38 | -15 | 17 | OWXL | 8 | 2 | 2 | 4 | 10 | 12 | 10 | 3 | 0 | 7 | 13 | 26 | ||
| 15 | +2 | Óttar KARLSSON (Oakland Roots, 6p) |
| 12 | Milan ILOSKI (Orange County SC) | |
| 11 | +1 | Phillip GOODRUM (Memphis 901) |
| +1 | Hadji BARRY (Colorado Springs, 2p) | |
| Preston JUDD (LA Galaxy 2) | ||
| 10 | Kyle VASSELL (San Diego Loyal, 1p) | |
| +1 | Leonardo FERNANDES (Tampa Bay Rowdies, 4p) | |
| +1 | Jake LACAVA (Tampa Bay Rowdies) | |
| 9 | +2 | Augustine WILLIAMS (Charleston Battery, 1p) |
| Danny TREJO (Las Vegas Lights) | ||
| +2 | Elvis AMOH (Colorado Springs) | |
| 8 | Erick TORRES (Orange County SC, 2p) | |
| +1 | Michee NGALINA (Colorado Springs) | |
| Jerome 'J.J.' WILLIAMS (FC Tulsa) | ||
| Russell CICERONE (Pittsburgh Riverhounds) | ||
| Luis SOLIGNAC (El Paso Locomotive, 1p) | ||
| Wilson HARRIS (Louisville City, 1p) | ||
| 7 | STÉFANO Souza (Indy Eleven) | |
| +1 | Cameron DUNBAR (LA Galaxy 2, 2p) | |
| RODRIGO BANDEIRA da Costa (FC Tulsa) | ||
| +1 | Dane KELLY (Pittsburgh Riverhounds) | |
| +2 | Brian OWNBY (Louisville City) |
| Wednesday, 13 July 2022 | |||||
| FC Tulsa | 1-2 | New Mexico United | |||
| 70(og) | Tetteh | 54 | Souahy | ||
| 76(p) | Portillo | ||||
| Miami FC | 1-0 | Charleston Battery | |||
| 4 | Parkes | ||||
| Friday, 15 July 2022 | |||||
| Colorado Springs | 4-2 | LA Galaxy 2 | |||
| 20 | Ngalina | 45(p) | Dunbar | ||
| 27 | Barry | 90 | Johnson | ||
| 58 | Amoh | ||||
| 90 | Amoh | ||||
| New York Red Bulls 2 | 1-0 | Indy Eleven | |||
| 53 | Rafanello | ||||
| Saturday, 16 July 2022 | |||||
| Charleston Battery | 3-1 | Hartford Athletic | |||
| 13 | Williams | 22 | Saydee | ||
| 25 | Kwakwa | ||||
| 53 | Williams | ||||
| Orange County SC | 0-0 | Miami FC | |||
| San Antonio | 5-0 | Atlanta United 2 | |||
| 13 | Adeniran | ||||
| 16 | Patiño | ||||
| 33(p) | Patiño | ||||
| 51 | Adeniran | ||||
| 88 | Dhillon | ||||
| Sacramento Republic | 0-1 | Birmingham Legion | |||
| 2 | Agudelo | ||||
| Memphis 901 | 1-2 | Louisville City | |||
| 66 | Goodrum | 72 | Ownby | ||
| 81 | Ownby | ||||
| New Mexico United | 1-1 | Pittsburgh Riverhounds | |||
| 1 | Kiesewetter | 75 | Kelly | ||
| Loudoun United | 1-4 | Tampa Bay Rowdies | |||
| 80 | Freeman | 64 | Lacava | ||
| 68 | Duba | ||||
| 73 | Fernandes | ||||
| 82 | Dalgaard | ||||
| Oakland Roots | 4-0 | El Paso Locomotive | |||
| 21 | Karlsson | ||||
| 32(p) | Karlsson | ||||
| 34 | Formella | ||||
| 40 | Hernández | ||||
| Monterey Bay | 0-0 | Detroit City | |||