| ROUND | R1 | QF | SF | F | |||
| l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Tuesday, 27 April 2021 | ||||||
| qfl1 |  Toronto FC | 1-3 | Cruz Azul | |||
| qfl1 | Atlanta United | 0-3 | Philadelphia Union | |||
| Wednesday, 28 April 2021 | ||||||
| qfl1 | Columbus Crew | 2-2 | Monterrey | |||
| qfl1 | Portland Timbers | 1-1 | América | |||
| Tuesday, 4 May 2021 | ||||||
| qfl2 | Cruz Azul | 1-0 | Toronto FC | 4-1 | ||
| qfl2 | Philadelphia Union | 1-1 | Atlanta United | 4-1 | ||
| Wednesday, 5 May 2021 | ||||||
| qfl2 | América | 3-1 | Portland Timbers | 4-2 | ||
| qfl2 | Monterrey | 3-0 | Columbus Crew | 5-2 | ||
| 5 | +3 | Kacper PRZYBYŁKO (Philadelphia Union) |
| 4 | +3 | Brayan ANGULO (Cruz Azul) |
| 3 | +2 | Federico VIÑAS (América, 1p) |
| Yimmi CHARÁ (Portland Timbers) | ||
| 2 | Vincent JANSSEN (Monterrey) | |
| Fernando NAVARRO (León) | ||
| Walter MONTOYA (Cruz Azul) | ||
| +2 | Maximiliano MEZA (Monterrey) | |
| +1 | José ALVARADO (Monterrey) | |
| Gyasi ZARDES (Columbus Crew) | ||
| Jamiro MONTEIRO (Philadelphia Union, 1p) | ||
| +1 | Diego VALERI (Portland Timbers, 1p) | |
| +1 | Felipe MORA (Portland Timbers, 1p) | |
| +1 | Anthony FONTANA (Philadelphia Union) |
