| ROUND | R1 | QF | SF | F | |||
| l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Wednesday, 11 August 2021 | |||||
| sfl1 |  Monterrey | 1-0 | Cruz Azul | ||
| 9 | Meza | ||||
| Thursday, 12 August 2021 | |||||
| sfl1 | América | 2-0 | Philadelphia Union | ||
| 17 | Sánchez | ||||
| 80(p) | Aguilera | ||||
| 5 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| 4 | Brayan ANGULO (Cruz Azul) | |
| 3 | +1 | Maximiliano MEZA (Monterrey) |
| Federico VIÑAS (América, 1p) | ||
| Yimmi CHARÁ (Portland Timbers) | ||
| 2 | Vincent JANSSEN (Monterrey) | |
| Fernando NAVARRO (León) | ||
| Walter MONTOYA (Cruz Azul) | ||
| José ALVARADO (Monterrey) | ||
| Gyasi ZARDES (Columbus Crew) | ||
| Jamiro MONTEIRO (Philadelphia Union, 1p) | ||
| Diego VALERI (Portland Timbers, 1p) | ||
| Felipe MORA (Portland Timbers, 1p) | ||
| Anthony FONTANA (Philadelphia Union) |
