| ROUND | R1 | QF | SF | F | |||
| l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Tuesday, 13 April 2021 | ||||||
| r1l2 |  Cruz Azul | 8-0 | Arcahaie | 8-0 | ||
| 3 | Gutiérrez | |||||
| 11 | Yotún | |||||
| 25 | Hernández | |||||
| 49 | Montoya | |||||
| 61 | Reyes | |||||
| 64 | Montoya | |||||
| 69 | Angulo | |||||
| 76 | Escobar | |||||
| r1l2 |  Portland Timbers | 5-0 | Marathón | 7-2 | ||
| 19 | Chará | |||||
| 36 | Chará | |||||
| 66 | Valeri | |||||
| 79 | Chará | |||||
| 89 | Loría | |||||
| r1l2 | Atlanta United | 1-0 | Alajuelense | 2-0 | ||
| 90 | Damm | |||||
| Wednesday, 14 April 2021 | ||||||
| r1l2 | América | 0-1 | Olimpia | 2-2 | ||
| 50 | Bengtson | |||||
| r1l2 | Toronto FC | 2-1 | León | 3-2 | ||
| 55 | Mullins | 80 | Navarro | |||
| 72 | Morrow | |||||
| r1l2 | Philadelphia Union | 4-0 | Saprissa | 5-0 | ||
| 47(p) | Monteiro | |||||
| 51 | Przybyłko | |||||
| 55 | Fontana | |||||
| 90 | Monteiro | |||||
| Thursday, 15 April 2021 | ||||||
| r1l2 | Columbus Crew | 1-0 | Real Estelí | 5-0 | ||
| 86 | Wright-Phillips | |||||
| r1l2 | Monterrey | 3-1 | Pantoja | 6-1 | ||
| 9 | Sánchez | 61 | ||||
| 14 | Janssen | |||||
| 79 | Gallardo | |||||
| 3 | +3 | Yimmi CHARÁ (Portland Timbers) |
| 2 | +1 | Vincent JANSSEN (Monterrey) |
| +1 | Fernando NAVARRO (León) | |
| +2 | Walter MONTOYA (Cruz Azul) | |
| Gyasi ZARDES (Columbus Crew) | ||
| +1 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| +2 | Jamiro MONTEIRO (Philadelphia Union, 1p) |
