| ROUND | R1 | QF | SF | F | |||
| l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Tuesday, 27 April 2021 | |||||
| qfl1 |  Toronto FC | 1-3 | Cruz Azul | ||
| 20 | Osorio | 3 | Angulo | ||
| 34 | Angulo | ||||
| 58 | Aguilar | ||||
| qfl1 | Atlanta United | 0-3 | Philadelphia Union | ||
| 57 | Przybyłko | ||||
| 73 | Przybyłko | ||||
| 86 | Fontana | ||||
| Wednesday, 28 April 2021 | |||||
| qfl1 | Columbus Crew | 2-2 | Monterrey | ||
| 66 | Valenzuela | 9 | Loba | ||
| 87 | Zelarayán | 90 | Alvarado | ||
| qfl1 | Portland Timbers | 1-1 | América | ||
| 90(p) | Mora | 45(p) | Martínez | ||
| 4 | +2 | Kacper PRZYBYŁKO (Philadelphia Union) |
| 3 | +2 | Brayan ANGULO (Cruz Azul) |
| Yimmi CHARÁ (Portland Timbers) | ||
| 2 | Vincent JANSSEN (Monterrey) | |
| Fernando NAVARRO (León) | ||
| Walter MONTOYA (Cruz Azul) | ||
| +1 | José ALVARADO (Monterrey) | |
| Gyasi ZARDES (Columbus Crew) | ||
| Jamiro MONTEIRO (Philadelphia Union, 1p) | ||
| +1 | Felipe MORA (Portland Timbers, 1p) | |
| +1 | Anthony FONTANA (Philadelphia Union) |
