| ROUND | R1 | QF | SF | F | |||
| l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Wednesday, 11 August 2021 | ||||||
| sfl1 |  Monterrey | 1-0 | Cruz Azul | |||
| Thursday, 12 August 2021 | ||||||
| sfl1 | América | 2-0 | Philadelphia Union | |||
| Wednesday, 15 September 2021 | ||||||
| sfl2 | Philadelphia Union | 0-2 | América | 0-4 | ||
| Thursday, 16 September 2021 | ||||||
| sfl2 | Cruz Azul | 1-4 | Monterrey | 1-5 | ||
| 5 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| 4 | +2 | Maximiliano MEZA (Monterrey) |
| Brayan ANGULO (Cruz Azul) | ||
| 3 | Federico VIÑAS (América, 1p) | |
| Yimmi CHARÁ (Portland Timbers) | ||
| 2 | Vincent JANSSEN (Monterrey) | |
| Fernando NAVARRO (León) | ||
| Walter MONTOYA (Cruz Azul) | ||
| José ALVARADO (Monterrey) | ||
| Gyasi ZARDES (Columbus Crew) | ||
| Jamiro MONTEIRO (Philadelphia Union, 1p) | ||
| Diego VALERI (Portland Timbers, 1p) | ||
| Felipe MORA (Portland Timbers, 1p) | ||
| +2 | Rogelio FUNES (Monterrey) | |
| Anthony FONTANA (Philadelphia Union) |
