| ROUND | R1 | QF | SF | F | |||
| l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Tuesday, 6 April 2021 | ||||||
| r1l1 |  Alajuelense | 0-1 | Atlanta United | |||
| r1l1 |  Marathón | 2-2 | Portland Timbers | |||
| r1l1 |  Arcahaie | 0-0 | Cruz Azul | |||
| Wednesday, 7 April 2021 | ||||||
| r1l1 | León | 1-1 | Toronto FC | |||
| r1l1 | Olimpia | 1-2 | América | |||
| r1l1 | Saprissa | 0-1 | Philadelphia Union | |||
| Thursday, 8 April 2021 | ||||||
| r1l1 |  Real Estelí | 0-4 | Columbus Crew | |||
| r1l1 |  Pantoja | 0-3 | Monterrey | |||
| Tuesday, 13 April 2021 | ||||||
| r1l2 | Cruz Azul | 8-0 | Arcahaie | 8-0 | ||
| r1l2 | Portland Timbers | 5-0 | Marathón | 7-2 | ||
| r1l2 | Atlanta United | 1-0 | Alajuelense | 2-0 | ||
| Wednesday, 14 April 2021 | ||||||
| r1l2 | América | 0-1 | Olimpia | 2-2 | ||
| r1l2 | Toronto FC | 2-1 | León | 3-2 | ||
| r1l2 | Philadelphia Union | 4-0 | Saprissa | 5-0 | ||
| Thursday, 15 April 2021 | ||||||
| r1l2 | Columbus Crew | 1-0 | Real Estelí | 5-0 | ||
| r1l2 | Monterrey | 3-1 | Pantoja | 6-1 | ||
| 3 | +3 | Yimmi CHARÁ (Portland Timbers) |
| 2 | +2 | Vincent JANSSEN (Monterrey) |
| +2 | Fernando NAVARRO (León) | |
| +2 | Walter MONTOYA (Cruz Azul) | |
| +2 | Gyasi ZARDES (Columbus Crew) | |
| +2 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| +2 | Jamiro MONTEIRO (Philadelphia Union, 1p) |
