| ROUND | R1 | QF | SF | F | |||
| l1 | l2 | l1 | l2 | l1 | l2 | ||
| Season archive |
| Tuesday, 6 April 2021 | |||||
| r1l1 |  Alajuelense | 0-1 | Atlanta United | ||
| 50(p) | Barco | ||||
| r1l1 |  Marathón | 2-2 | Portland Timbers | ||
| 39 | Castillo | 35 | Mora | ||
| 68 | Ramírez | 59(og) | Torres | ||
| r1l1 |  Arcahaie | 0-0 | Cruz Azul | ||
| Wednesday, 7 April 2021 | |||||
| r1l1 | León | 1-1 | Toronto FC | ||
| 25 | Navarro | 51(og) | Mosquera | ||
| r1l1 | Olimpia | 1-2 | América | ||
| 89 | Arboleda | 41 | Viñas | ||
| 44 | Díaz | ||||
| r1l1 | Saprissa | 0-1 | Philadelphia Union | ||
| 34 | Przybyłko | ||||
| Thursday, 8 April 2021 | |||||
| r1l1 |  Real Estelí | 0-4 | Columbus Crew | ||
| 19 | Zardes | ||||
| 26 | Mensah | ||||
| 33 | Zardes | ||||
| 45(p) | Pedro Santos | ||||
| r1l1 |  Pantoja | 0-3 | Monterrey | ||
| 32 | Janssen | ||||
| 42 | González | ||||
| 70 | Alvarado | ||||
| 2 | +2 | Gyasi ZARDES (Columbus Crew) |
| 1 | +1 | Yustin ARBOLEDA (Olimpia) |
| +1 | Sergio DÍAZ (América) | |
| +1 | Jonathan MENSAH (Columbus Crew) | |
| +1 | Vincent JANSSEN (Monterrey) | |
| +1 | Arturo GONZÁLEZ (Monterrey) | |
| +1 | Fernando NAVARRO (León) | |
| +1 | PEDRO Miguel SANTOS (Columbus Crew, 1p) | |
| +1 | José ALVARADO (Monterrey) | |
| +1 | Marlon RAMÍREZ (Marathón) | |
| +1 | Ezequiel BARCO (Atlanta United, 1p) | |
| +1 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| +1 | Federico VIÑAS (América) | |
| +1 | Felipe MORA (Portland Timbers) | |
| +1 | Brayan CASTILLO (Marathón) |
