Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 52 | 145 | 2.78 | 26 | 50.00% | 15 | 28.85% | 11 | 21.15% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | New York City | 4 | 2 | 1 | 1 | 9 | 3 | +6 | 7 | XWWL | 1 | 1 | 0 | 0 | 5 | 0 | 3 | 1 | 1 | 1 | 4 | 3 | |
| 2 | 1 | New England Revolution | 4 | 2 | 1 | 1 | 5 | 5 | +0 | 7 | LWWX | 2 | 2 | 0 | 0 | 3 | 1 | 2 | 0 | 1 | 1 | 2 | 4 | |
| 3 | 4 | New York Red Bulls | 4 | 2 | 0 | 2 | 7 | 5 | +2 | 6 | WWLL | 3 | 2 | 0 | 1 | 5 | 2 | 1 | 0 | 0 | 1 | 2 | 3 | |
| 4 | 1 | Orlando City | 4 | 1 | 3 | 0 | 5 | 2 | +3 | 6 | XWXO | 3 | 1 | 2 | 0 | 4 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | |
| 5 | 4 | Nashville | 4 | 1 | 3 | 0 | 6 | 4 | +2 | 6 | WOXX | 4 | 1 | 3 | 0 | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 6 | 4 | Columbus Crew | 3 | 1 | 2 | 0 | 3 | 1 | +2 | 5 | WOO- | 2 | 1 | 1 | 0 | 3 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | |
| 7 | 2 | Atlanta United | 4 | 1 | 2 | 1 | 5 | 4 | +1 | 5 | XLWO | 1 | 1 | 0 | 0 | 3 | 1 | 3 | 0 | 2 | 1 | 2 | 3 | |
| 8 | 4 | CF Montréal | 4 | 1 | 2 | 1 | 6 | 6 | +0 | 5 | LOXW | 2 | 1 | 1 | 0 | 4 | 2 | 2 | 0 | 1 | 1 | 2 | 4 | |
| 9 | 3 | Inter Miami | 4 | 1 | 2 | 1 | 5 | 5 | +0 | 5 | XOWL | 2 | 0 | 1 | 1 | 3 | 4 | 2 | 1 | 1 | 0 | 2 | 1 | |
| 10 | 2 | Philadelphia Union | 4 | 1 | 1 | 2 | 3 | 4 | -1 | 4 | WLLO | 2 | 0 | 0 | 2 | 1 | 4 | 2 | 1 | 1 | 0 | 2 | 0 | |
| 11 | 3 | D.C. United | 4 | 1 | 0 | 3 | 4 | 9 | -5 | 3 | LLLW | 1 | 1 | 0 | 0 | 2 | 1 | 3 | 0 | 0 | 3 | 2 | 8 | |
| 12 | 1 | Toronto FC | 3 | 0 | 1 | 2 | 4 | 8 | -4 | 1 | LXL- | 1 | 0 | 1 | 0 | 2 | 2 | 2 | 0 | 0 | 2 | 2 | 6 | |
| 13 | Chicago Fire | 4 | 0 | 1 | 3 | 3 | 9 | -6 | 1 | LLLX | 2 | 0 | 1 | 1 | 2 | 4 | 2 | 0 | 0 | 2 | 1 | 5 | ||
| 14 | FC Cincinnati | 3 | 0 | 1 | 2 | 2 | 10 | -8 | 1 | LLX- | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 2 | 10 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 4 | 3 | 1 | 0 | 10 | 2 | +8 | 10 | WWXW | 2 | 2 | 0 | 0 | 7 | 0 | 2 | 1 | 1 | 0 | 3 | 2 | ||
| 2 | San Jose Earthquakes | 4 | 3 | 0 | 1 | 10 | 5 | +5 | 9 | WWWL | 2 | 2 | 0 | 0 | 7 | 2 | 2 | 1 | 0 | 1 | 3 | 3 | ||
| 3 | 2 | LA Galaxy | 4 | 3 | 0 | 1 | 8 | 8 | +0 | 9 | WLWW | 2 | 2 | 0 | 0 | 5 | 3 | 2 | 1 | 0 | 1 | 3 | 5 | |
| 4 | 5 | Vancouver Whitecaps | 4 | 2 | 1 | 1 | 5 | 3 | +2 | 7 | WLXW | 3 | 2 | 0 | 1 | 3 | 1 | 1 | 0 | 1 | 0 | 2 | 2 | |
| 5 | 5 | Sporting Kansas City | 4 | 2 | 1 | 1 | 6 | 6 | +0 | 7 | WLXW | 2 | 1 | 1 | 0 | 3 | 2 | 2 | 1 | 0 | 1 | 3 | 4 | |
| 6 | 5 | Colorado Rapids | 4 | 2 | 1 | 1 | 5 | 5 | +0 | 7 | WWLO | 2 | 1 | 0 | 1 | 4 | 5 | 2 | 1 | 1 | 0 | 1 | 0 | |
| 7 | 4 | Real Salt Lake | 3 | 2 | 0 | 1 | 6 | 4 | +2 | 6 | LWW- | 2 | 1 | 0 | 1 | 4 | 3 | 1 | 1 | 0 | 0 | 2 | 1 | |
| 8 | 4 | Austin FC | 4 | 2 | 0 | 2 | 5 | 5 | +0 | 6 | LWWL | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 2 | 5 | 5 | |
| 9 | 2 | FC Dallas | 4 | 1 | 2 | 1 | 6 | 5 | +1 | 5 | XWLO | 3 | 1 | 2 | 0 | 5 | 2 | 1 | 0 | 0 | 1 | 1 | 3 | |
| 10 | 4 | Los Angeles | 4 | 1 | 2 | 1 | 5 | 4 | +1 | 5 | LXXW | 2 | 1 | 1 | 0 | 3 | 1 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 11 | 3 | Houston Dynamo | 4 | 1 | 2 | 1 | 5 | 5 | +0 | 5 | XXLW | 2 | 1 | 1 | 0 | 3 | 2 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 12 | Portland Timbers | 4 | 1 | 0 | 3 | 4 | 8 | -4 | 3 | LLWL | 2 | 1 | 0 | 1 | 3 | 3 | 2 | 0 | 0 | 2 | 1 | 5 | ||
| 13 | Minnesota United | 4 | 0 | 0 | 4 | 3 | 10 | -7 | 0 | LLLL | 2 | 0 | 0 | 2 | 1 | 3 | 2 | 0 | 0 | 2 | 2 | 7 | ||
| 6 | +1 | Javier HERNÁNDEZ (LA Galaxy) |
| 5 | +1 | Raúl RUIDÍAZ (Seattle Sounders, 1p) |
| 4 | +1 | Valentín CASTELLANOS (New York City, 1p) |
| 3 | +2 | Cristian DÁJOME (Vancouver Whitecaps, 2p) |
| +1 | NANI (Orlando City) | |
| +1 | Caden CLARK (New York Red Bulls) | |
| +1 | Rubio RUBIN (Real Salt Lake) | |
| Jesús MEDINA (New York City) | ||
| 2 | Mason TOYE (CF Montréal) | |
| Brad SMITH (Seattle Sounders) | ||
| Cade COWELL (San Jose Earthquakes) | ||
| +2 | Chris WONDOLOWSKI (San Jose Earthquakes) | |
| Corey BAIRD (Los Angeles) | ||
| +1 | Gadi KINDA (Sporting Kansas City, 1p) | |
| Jackson YUEILL (San Jose Earthquakes) | ||
| Luka STOJANOVIĆ (Chicago Fire) | ||
| +1 | Jáder OBRIAN (FC Dallas) | |
| Cristian CÁSSERES (New York Red Bulls) | ||
| +1 | Fredy MONTERO (Seattle Sounders) | |
| Anderson JULIO (Real Salt Lake) | ||
| Cecilio DOMÍNGUEZ (Austin FC) | ||
| Jhonder CÁDIZ (Nashville) | ||
| Diego FAGÚNDEZ (Austin FC) | ||
| Gonzalo HIGUAÍN (Inter Miami, 1p) |
| Friday, 7 May 2021 | |||||
| Real Salt Lake | 1-2 | San Jose Earthquakes | |||
| 43 | Rubin | 83 | Wondolowski | ||
| 87 | Wondolowski | ||||
| Saturday, 8 May 2021 | |||||
| FC Dallas | 1-1 | Houston Dynamo | |||
| 42 | Obrian | 34(p) | Picault | ||
| Colorado Rapids | 3-2 | Minnesota United | |||
| 57 | Acosta | 17 | Reynoso | ||
| 71 | Bassett | 24 | Dotson | ||
| 82 | Wilson | ||||
| New York Red Bulls | 2-0 | Toronto FC | |||
| 32 | Amaya | ||||
| 69 | Clark | ||||
| Columbus Crew | 3-1 | D.C. United | |||
| 20 | Zelarayán | 82 | Kamara | ||
| 63(og) | Brillant | ||||
| 83(og) | Alfaro | ||||
| LA Galaxy | 2-1 | Los Angeles | |||
| 11 | Hernández | 62 | Rossi | ||
| 79 | Dos Santos | ||||
| Chicago Fire | 0-2 | Philadelphia Union | |||
| 51 | Burke | ||||
| 60 | Glesnes | ||||
| Vancouver Whitecaps | 2-0 | CF Montréal | |||
| 57(p) | Dájome | ||||
| 71 | Dájome | ||||
| Orlando City | 1-1 | New York City | |||
| 52 | Nani | 77(p) | Castellanos | ||
| Nashville | 2-0 | New England Revolution | |||
| 25 | Sapong | ||||
| 75 | Muyl | ||||
| Sunday, 9 May 2021 | |||||
| Sporting Kansas City | 2-1 | Austin FC | |||
| 82 | Ilie | 7 | Gallagher | ||
| 90 | Kinda | ||||
| Portland Timbers | 1-2 | Seattle Sounders | |||
| 90 | Tuiloma | 63(p) | Ruidíaz | ||
| 79 | Montero | ||||
| Inter Miami | 1-1 | Atlanta United | |||
| 77 | Morgan | 9 | Martínez | ||
