Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 337 | 930 | 2.75 | 160 | 47.48% | 93 | 27.60% | 84 | 24.93% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 27 | 18 | 5 | 4 | 51 | 32 | +19 | 59 | WXWW | 13 | 10 | 2 | 1 | 26 | 14 | 14 | 8 | 3 | 3 | 25 | 18 | ||
| 2 | Nashville | 25 | 11 | 11 | 3 | 44 | 24 | +20 | 44 | WLWW | 14 | 8 | 6 | 0 | 31 | 14 | 11 | 3 | 5 | 3 | 13 | 10 | ||
| 3 | 1 | New York City | 25 | 11 | 6 | 8 | 44 | 29 | +15 | 39 | XWXL | 12 | 8 | 2 | 2 | 29 | 11 | 13 | 3 | 4 | 6 | 15 | 18 | |
| 4 | 1 | Orlando City | 25 | 10 | 8 | 7 | 36 | 36 | +0 | 38 | LLLW | 13 | 7 | 4 | 2 | 23 | 13 | 12 | 3 | 4 | 5 | 13 | 23 | |
| 5 | 1 | CF Montréal | 25 | 10 | 7 | 8 | 36 | 30 | +6 | 37 | WWLW | 12 | 7 | 3 | 2 | 22 | 14 | 13 | 3 | 4 | 6 | 14 | 16 | |
| 6 | 1 | Atlanta United | 25 | 9 | 9 | 7 | 35 | 30 | +5 | 36 | WWWL | 13 | 7 | 3 | 3 | 20 | 11 | 12 | 2 | 6 | 4 | 15 | 19 | |
| 7 | 2 | Philadelphia Union | 24 | 9 | 8 | 7 | 31 | 25 | +6 | 35 | WLLX | 13 | 7 | 3 | 3 | 18 | 10 | 11 | 2 | 5 | 4 | 13 | 15 | |
| 8 | 3 | D.C. United | 25 | 10 | 4 | 11 | 41 | 36 | +5 | 34 | LWXW | 11 | 8 | 0 | 3 | 21 | 8 | 14 | 2 | 4 | 8 | 20 | 28 | |
| 9 | 1 | Inter Miami | 25 | 9 | 5 | 11 | 25 | 40 | -15 | 32 | LLWW | 14 | 5 | 2 | 7 | 17 | 31 | 11 | 4 | 3 | 4 | 8 | 9 | |
| 10 | Columbus Crew | 26 | 8 | 7 | 11 | 30 | 35 | -5 | 31 | XWLL | 12 | 6 | 3 | 3 | 21 | 17 | 14 | 2 | 4 | 8 | 9 | 18 | ||
| 11 | New York Red Bulls | 24 | 7 | 6 | 11 | 30 | 29 | +1 | 27 | XWLX | 12 | 5 | 4 | 3 | 15 | 10 | 12 | 2 | 2 | 8 | 15 | 19 | ||
| 12 | Chicago Fire | 26 | 6 | 5 | 15 | 26 | 43 | -17 | 23 | LLLL | 14 | 5 | 4 | 5 | 20 | 18 | 12 | 1 | 1 | 10 | 6 | 25 | ||
| 13 | FC Cincinnati | 24 | 4 | 8 | 12 | 24 | 44 | -20 | 20 | LLWL | 11 | 1 | 5 | 5 | 9 | 13 | 13 | 3 | 3 | 7 | 15 | 31 | ||
| 14 | Toronto FC | 25 | 4 | 6 | 15 | 28 | 51 | -23 | 18 | WLLL | 11 | 2 | 5 | 4 | 14 | 16 | 14 | 2 | 1 | 11 | 14 | 35 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sporting Kansas City | 25 | 13 | 7 | 5 | 43 | 26 | +17 | 46 | WWLX | 13 | 7 | 5 | 1 | 25 | 12 | 12 | 6 | 2 | 4 | 18 | 14 | ||
| 2 | Seattle Sounders | 24 | 13 | 6 | 5 | 36 | 20 | +16 | 45 | LWLW | 13 | 6 | 4 | 3 | 19 | 11 | 11 | 7 | 2 | 2 | 17 | 9 | ||
| 3 | Colorado Rapids | 24 | 12 | 8 | 4 | 35 | 24 | +11 | 44 | XXXW | 12 | 6 | 5 | 1 | 20 | 11 | 12 | 6 | 3 | 3 | 15 | 13 | ||
| 4 | LA Galaxy | 25 | 11 | 5 | 9 | 37 | 40 | -3 | 38 | LXXX | 13 | 7 | 2 | 4 | 21 | 15 | 12 | 4 | 3 | 5 | 16 | 25 | ||
| 5 | Portland Timbers | 25 | 11 | 4 | 10 | 36 | 42 | -6 | 37 | WXWW | 12 | 7 | 2 | 3 | 21 | 18 | 13 | 4 | 2 | 7 | 15 | 24 | ||
| 6 | Real Salt Lake | 25 | 10 | 6 | 9 | 41 | 35 | +6 | 36 | WWLW | 13 | 7 | 4 | 2 | 21 | 12 | 12 | 3 | 2 | 7 | 20 | 23 | ||
| 7 | 1 | Minnesota United | 24 | 9 | 7 | 8 | 27 | 29 | -2 | 34 | WLLW | 12 | 7 | 2 | 3 | 15 | 7 | 12 | 2 | 5 | 5 | 12 | 22 | |
| 8 | 1 | Los Angeles | 25 | 9 | 6 | 10 | 38 | 36 | +2 | 33 | LWWW | 13 | 6 | 5 | 2 | 26 | 19 | 12 | 3 | 1 | 8 | 12 | 17 | |
| 9 | Vancouver Whitecaps | 24 | 7 | 9 | 8 | 30 | 34 | -4 | 30 | XLWW | 12 | 6 | 2 | 4 | 16 | 14 | 12 | 1 | 7 | 4 | 14 | 20 | ||
| 10 | 1 | San Jose Earthquakes | 25 | 7 | 9 | 9 | 32 | 38 | -6 | 30 | WLXL | 12 | 3 | 3 | 6 | 16 | 19 | 13 | 4 | 6 | 3 | 16 | 19 | |
| 11 | 1 | FC Dallas | 26 | 6 | 9 | 11 | 38 | 43 | -5 | 27 | LXXL | 12 | 4 | 6 | 2 | 19 | 12 | 14 | 2 | 3 | 9 | 19 | 31 | |
| 12 | Houston Dynamo | 26 | 5 | 11 | 10 | 31 | 39 | -8 | 26 | WXWL | 13 | 5 | 5 | 3 | 19 | 17 | 13 | 0 | 6 | 7 | 12 | 22 | ||
| 13 | Austin FC | 25 | 5 | 4 | 16 | 25 | 40 | -15 | 19 | LLLL | 12 | 3 | 2 | 7 | 18 | 21 | 13 | 2 | 2 | 9 | 7 | 19 | ||
| 16 | Ola KAMARA (D.C. United, 7p) | |
| 14 | Raúl RUIDÍAZ (Seattle Sounders, 2p) | |
| 13 | +2 | Valentín CASTELLANOS (New York City, 3p) |
| Dániel SALLÓI (Sporting Kansas City) | ||
| 12 | +2 | Hany MUKHTAR (Nashville, 1p) |
| Gustavo BOU (New England Revolution, 1p) | ||
| Ricardo PEPI (FC Dallas) | ||
| 11 | Javier HERNÁNDEZ (LA Galaxy) | |
| +1 | Adam BUKSA (New England Revolution) | |
| 10 | +1 | Fabrice PICAULT (Houston Dynamo, 3p) |
| +2 | Javier LÓPEZ (San Jose Earthquakes, 1p) | |
| Felipe MORA (Portland Timbers, 1p) | ||
| +1 | C.J. SAPONG (Nashville) | |
| +1 | Damir KREILACH (Real Salt Lake) | |
| +1 | Gonzalo HIGUAÍN (Inter Miami, 2p) | |
| 9 | NANI (Orlando City, 2p) | |
| +1 | Josef MARTÍNEZ (Atlanta United, 1p) | |
| 8 | Cristian DÁJOME (Vancouver Whitecaps, 3p) | |
| +2 | Jáder OBRIAN (FC Dallas) | |
| Alan PULIDO (Sporting Kansas City, 2p) | ||
| +2 | Kacper PRZYBYŁKO (Philadelphia Union, 1p) | |
| Jesús MEDINA (New York City) |
| Friday, 17 September 2021 | |||||
| Inter Miami | 0-4 | New York Red Bulls | |||
| 18 | Klimala | ||||
| 31 | Fernandez | ||||
| 65 | Fábio | ||||
| 89 | Fábio | ||||
| Saturday, 18 September 2021 | |||||
| Houston Dynamo | 3-2 | FC Dallas | |||
| 5 | Dorsey | 86 | Obrian | ||
| 20 | Picault | 90 | Obrian | ||
| 59(p) | Quintero | ||||
| New England Revolution | 1-1 | Columbus Crew | |||
| 62 | Buksa | 58 | Zardes | ||
| Real Salt Lake | 1-0 | Seattle Sounders | |||
| 48 | Kreilach | ||||
| Toronto FC | 2-1 | Nashville | |||
| 18 | Shaffelburg | 74 | Sapong | ||
| 79 | González | ||||
| Minnesota United | 3-0 | LA Galaxy | |||
| 4 | Reynoso | ||||
| 20 | Reynoso | ||||
| 66 | Finlay | ||||
| Austin FC | 3-4 | San Jose Earthquakes | |||
| 6 | Driussi | 17 | López | ||
| 35 | Gallagher | 49 | Espinoza | ||
| 45 | Ring | 58(p) | López | ||
| 63 | López | ||||
| Atlanta United | 3-2 | D.C. United | |||
| 18 | Barco | 75 | Felipe | ||
| 64 | Martínez | 90 | Flores | ||
| 87 | Bello | ||||
| FC Cincinnati | 1-2 | New York City | |||
| 4 | Brenner | 37 | Parks | ||
| 60(p) | Castellanos | ||||
| Sunday, 19 September 2021 | |||||
| Colorado Rapids | 1-1 | Vancouver Whitecaps | |||
| 28 | Wilson | 41 | White | ||
| CF Montréal | 2-0 | Chicago Fire | |||
| 60 | Quioto | ||||
| 80(og) | Terán | ||||
| Portland Timbers | 2-1 | Los Angeles | |||
| 21 | Asprilla | 27(p) | Arango | ||
| 68 | Fochive | ||||
| Philadelphia Union | 3-1 | Orlando City | |||
| 37 | Wagner | 57 | Ruan | ||
| 61 | Przybyłko | ||||
| 90(p) | Przybyłko | ||||
| Wednesday, 22 September 2021 | |||||
| New York Red Bulls | 1-1 | New York City | |||
| 90(p) | Klimala | 31 | Castellanos | ||
| Chicago Fire | 2-3 | New England Revolution | |||
| 40 | Terán | 11 | Kessler | ||
| 63 | Giménez | 62 | Bunbury | ||
| 90 | Carles Gil | ||||
| Inter Miami | 1-5 | Nashville | |||
| 64 | Higuaín | 6 | Mukhtar | ||
| 39 | Zimmerman | ||||
| 48 | Mukhtar | ||||
| 70 | Leal | ||||
| 90 | Johnston | ||||
