Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 309 | 825 | 2.66 | 147 | 47.57% | 87 | 28.16% | 75 | 24.27% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 25 | 17 | 4 | 4 | 47 | 29 | +18 | 55 | WWLW | 12 | 10 | 1 | 1 | 25 | 13 | 13 | 7 | 3 | 3 | 22 | 16 | ||
| 2 | 1 | Nashville | 23 | 10 | 11 | 2 | 38 | 21 | +17 | 41 | WWWX | 14 | 8 | 6 | 0 | 31 | 14 | 9 | 2 | 5 | 2 | 7 | 7 | |
| 3 | 1 | Orlando City | 23 | 10 | 8 | 5 | 33 | 29 | +4 | 38 | LWOW | 12 | 7 | 4 | 1 | 21 | 9 | 11 | 3 | 4 | 4 | 12 | 20 | |
| 4 | New York City | 22 | 10 | 4 | 8 | 38 | 24 | +14 | 34 | LLWL | 11 | 8 | 1 | 2 | 26 | 8 | 11 | 2 | 3 | 6 | 12 | 16 | ||
| 5 | Philadelphia Union | 23 | 8 | 8 | 7 | 28 | 24 | +4 | 32 | LLXW | 12 | 6 | 3 | 3 | 15 | 9 | 11 | 2 | 5 | 4 | 13 | 15 | ||
| 6 | 1 | D.C. United | 23 | 9 | 4 | 10 | 36 | 33 | +3 | 31 | XWLL | 10 | 7 | 0 | 3 | 18 | 8 | 13 | 2 | 4 | 7 | 18 | 25 | |
| 7 | 1 | CF Montréal | 23 | 8 | 7 | 8 | 30 | 28 | +2 | 31 | LWXO | 11 | 6 | 3 | 2 | 20 | 14 | 12 | 2 | 4 | 6 | 10 | 14 | |
| 8 | 1 | Atlanta United | 23 | 7 | 9 | 7 | 28 | 28 | +0 | 30 | WLWW | 11 | 5 | 3 | 3 | 13 | 9 | 12 | 2 | 6 | 4 | 15 | 19 | |
| 9 | 1 | Inter Miami | 22 | 8 | 5 | 9 | 23 | 31 | -8 | 29 | WWOW | 12 | 5 | 2 | 5 | 16 | 22 | 10 | 3 | 3 | 4 | 7 | 9 | |
| 10 | 2 | Columbus Crew | 24 | 7 | 6 | 11 | 27 | 33 | -6 | 27 | LLWL | 11 | 5 | 3 | 3 | 19 | 16 | 13 | 2 | 3 | 8 | 8 | 17 | |
| 11 | 1 | New York Red Bulls | 21 | 6 | 5 | 10 | 24 | 26 | -2 | 23 | XLWL | 11 | 5 | 3 | 3 | 14 | 9 | 10 | 1 | 2 | 7 | 10 | 17 | |
| 12 | 1 | Chicago Fire | 23 | 6 | 5 | 12 | 24 | 35 | -11 | 23 | LWLL | 13 | 5 | 4 | 4 | 18 | 15 | 10 | 1 | 1 | 8 | 6 | 20 | |
| 13 | FC Cincinnati | 22 | 4 | 8 | 10 | 23 | 38 | -15 | 20 | WLLL | 10 | 1 | 5 | 4 | 8 | 11 | 12 | 3 | 3 | 6 | 15 | 27 | ||
| 14 | Toronto FC | 23 | 3 | 6 | 14 | 26 | 49 | -23 | 15 | LLLL | 9 | 1 | 5 | 3 | 12 | 14 | 14 | 2 | 1 | 11 | 14 | 35 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 23 | 13 | 6 | 4 | 36 | 19 | +17 | 45 | WLWW | 13 | 6 | 4 | 3 | 19 | 11 | 10 | 7 | 2 | 1 | 17 | 8 | ||
| 2 | 1 | Sporting Kansas City | 24 | 12 | 7 | 5 | 39 | 26 | +13 | 43 | WLXO | 12 | 6 | 5 | 1 | 21 | 12 | 12 | 6 | 2 | 4 | 18 | 14 | |
| 3 | 1 | Colorado Rapids | 22 | 12 | 6 | 4 | 32 | 21 | +11 | 42 | XWXW | 11 | 6 | 4 | 1 | 19 | 10 | 11 | 6 | 2 | 3 | 13 | 11 | |
| 4 | LA Galaxy | 23 | 11 | 4 | 8 | 36 | 36 | +0 | 37 | XXLL | 12 | 7 | 1 | 4 | 20 | 14 | 11 | 4 | 3 | 4 | 16 | 22 | ||
| 5 | 1 | Portland Timbers | 23 | 10 | 3 | 10 | 32 | 39 | -7 | 33 | WWWL | 10 | 6 | 1 | 3 | 17 | 15 | 13 | 4 | 2 | 7 | 15 | 24 | |
| 6 | 1 | Minnesota United | 22 | 8 | 7 | 7 | 24 | 25 | -1 | 31 | LWOX | 11 | 6 | 2 | 3 | 12 | 7 | 11 | 2 | 5 | 4 | 12 | 18 | |
| 7 | Real Salt Lake | 22 | 8 | 6 | 8 | 34 | 29 | +5 | 30 | WLLW | 12 | 6 | 4 | 2 | 20 | 12 | 10 | 2 | 2 | 6 | 14 | 17 | ||
| 8 | Vancouver Whitecaps | 23 | 7 | 8 | 8 | 29 | 33 | -4 | 29 | LWWW | 12 | 6 | 2 | 4 | 16 | 14 | 11 | 1 | 6 | 4 | 13 | 19 | ||
| 9 | Los Angeles | 22 | 7 | 6 | 9 | 32 | 31 | +1 | 27 | WXLL | 12 | 5 | 5 | 2 | 23 | 17 | 10 | 2 | 1 | 7 | 9 | 14 | ||
| 10 | San Jose Earthquakes | 23 | 6 | 9 | 8 | 25 | 31 | -6 | 27 | XLWX | 11 | 3 | 3 | 5 | 13 | 15 | 12 | 3 | 6 | 3 | 12 | 16 | ||
| 11 | FC Dallas | 24 | 6 | 8 | 10 | 33 | 37 | -4 | 26 | XLWX | 12 | 4 | 6 | 2 | 19 | 12 | 12 | 2 | 2 | 8 | 14 | 25 | ||
| 12 | 1 | Houston Dynamo | 24 | 4 | 10 | 10 | 27 | 36 | -9 | 22 | WLLX | 12 | 4 | 5 | 3 | 16 | 15 | 12 | 0 | 5 | 7 | 11 | 21 | |
| 13 | 1 | Austin FC | 23 | 5 | 4 | 14 | 21 | 34 | -13 | 19 | LLLW | 10 | 3 | 2 | 5 | 14 | 15 | 13 | 2 | 2 | 9 | 7 | 19 | |
| 14 | Raúl RUIDÍAZ (Seattle Sounders, 2p) | |
| 13 | +1 | Ola KAMARA (D.C. United, 5p) |
| 12 | Dániel SALLÓI (Sporting Kansas City) | |
| Gustavo BOU (New England Revolution, 1p) | ||
| +1 | Ricardo PEPI (FC Dallas) | |
| 11 | Valentín CASTELLANOS (New York City, 2p) | |
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| Hany MUKHTAR (Nashville, 1p) | ||
| Adam BUKSA (New England Revolution) | ||
| 9 | NANI (Orlando City, 2p) | |
| Felipe MORA (Portland Timbers, 1p) | ||
| C.J. SAPONG (Nashville) | ||
| +1 | Gonzalo HIGUAÍN (Inter Miami, 2p) | |
| 8 | Cristian DÁJOME (Vancouver Whitecaps, 3p) | |
| +2 | Fabrice PICAULT (Houston Dynamo, 3p) | |
| Alan PULIDO (Sporting Kansas City, 2p) | ||
| Damir KREILACH (Real Salt Lake) | ||
| 7 | Mason TOYE (CF Montréal, 2p) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Marcelino MORENO (Atlanta United, 3p) | ||
| +1 | Tajon BUCHANAN (New England Revolution) | |
| Luka STOJANOVIĆ (Chicago Fire) | ||
| Jesús MEDINA (New York City) |
| Friday, 10 September 2021 | |||||
| Vancouver Whitecaps | 0-1 | Portland Timbers | |||
| 66(og) | Veselinović | ||||
| Atlanta United | 3-0 | Orlando City | |||
| 25 | Campbell | ||||
| 38(og) | Dike | ||||
| 72 | Barco | ||||
| Saturday, 11 September 2021 | |||||
| FC Dallas | 1-1 | San Jose Earthquakes | |||
| 50 | Pepi | 6(p) | Alanís | ||
| Houston Dynamo | 3-0 | Austin FC | |||
| 1 | Dorsey | ||||
| 24 | Picault | ||||
| 64 | Picault | ||||
| Colorado Rapids | 1-1 | LA Galaxy | |||
| 66 | Barrios | 80 | Grandsir | ||
| New York Red Bulls | 1-1 | D.C. United | |||
| 5 | Yearwood | 44(p) | Kamara | ||
| New England Revolution | 2-1 | New York City | |||
| 21 | Boateng | 11 | Rodríguez | ||
| 65 | Buchanan | ||||
| Sporting Kansas City | 2-0 | Chicago Fire | |||
| 4 | Mauri | ||||
| 6 | Russell | ||||
| CF Montréal | 0-1 | Nashville | |||
| 66 | Zimmerman | ||||
| Seattle Sounders | 1-0 | Minnesota United | |||
| 22 | João Paulo | ||||
| FC Cincinnati | 2-0 | Toronto FC | |||
| 39 | Brenner | ||||
| 58 | Medunjanin | ||||
| Inter Miami | 1-0 | Columbus Crew | |||
| 16 | Higuaín | ||||
