Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 82 | 209 | 2.54 | 44 | 53.66% | 19 | 23.17% | 19 | 23.17% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 3 | New England Revolution | 7 | 4 | 2 | 1 | 10 | 7 | +3 | 14 | WWXL | 4 | 4 | 0 | 0 | 7 | 2 | 3 | 0 | 2 | 1 | 3 | 5 | |
| 2 | 7 | Orlando City | 6 | 3 | 3 | 0 | 7 | 2 | +5 | 12 | WWXW | 4 | 2 | 2 | 0 | 5 | 1 | 2 | 1 | 1 | 0 | 2 | 1 | |
| 3 | 2 | New York City | 6 | 2 | 2 | 2 | 11 | 6 | +5 | 8 | LXXW | 3 | 1 | 1 | 1 | 7 | 3 | 3 | 1 | 1 | 1 | 4 | 3 | |
| 4 | 2 | Atlanta United | 5 | 2 | 2 | 1 | 6 | 4 | +2 | 8 | WXLW | 2 | 2 | 0 | 0 | 4 | 1 | 3 | 0 | 2 | 1 | 2 | 3 | |
| 5 | 2 | CF Montréal | 7 | 2 | 2 | 3 | 9 | 9 | +0 | 8 | LLWL | 3 | 1 | 1 | 1 | 5 | 4 | 4 | 1 | 1 | 2 | 4 | 5 | |
| 6 | 1 | Philadelphia Union | 6 | 2 | 2 | 2 | 5 | 5 | +0 | 8 | WXWL | 4 | 1 | 1 | 2 | 3 | 5 | 2 | 1 | 1 | 0 | 2 | 0 | |
| 7 | 3 | Columbus Crew | 6 | 2 | 2 | 2 | 5 | 5 | +0 | 8 | WLLW | 2 | 1 | 1 | 0 | 3 | 1 | 4 | 1 | 1 | 2 | 2 | 4 | |
| 8 | 4 | Inter Miami | 7 | 2 | 2 | 3 | 8 | 10 | -2 | 8 | LWLX | 3 | 0 | 1 | 2 | 3 | 6 | 4 | 2 | 1 | 1 | 5 | 4 | |
| 9 | 3 | Nashville | 5 | 1 | 4 | 0 | 6 | 4 | +2 | 7 | OWOX | 4 | 1 | 3 | 0 | 6 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | |
| 10 | 3 | New York Red Bulls | 6 | 2 | 0 | 4 | 8 | 9 | -1 | 6 | LLWW | 3 | 2 | 0 | 1 | 5 | 2 | 3 | 0 | 0 | 3 | 3 | 7 | |
| 11 | 3 | D.C. United | 6 | 2 | 0 | 4 | 5 | 10 | -5 | 6 | LWLL | 3 | 2 | 0 | 1 | 3 | 2 | 3 | 0 | 0 | 3 | 2 | 8 | |
| 12 | 1 | Toronto FC | 6 | 1 | 2 | 3 | 7 | 10 | -3 | 5 | LXWL | 2 | 1 | 1 | 0 | 4 | 2 | 4 | 0 | 1 | 3 | 3 | 8 | |
| 13 | Chicago Fire | 6 | 1 | 1 | 4 | 4 | 10 | -6 | 4 | WLLL | 3 | 1 | 1 | 1 | 3 | 4 | 3 | 0 | 0 | 3 | 1 | 6 | ||
| 14 | FC Cincinnati | 5 | 1 | 1 | 3 | 6 | 14 | -8 | 4 | WLLL | 1 | 0 | 0 | 1 | 2 | 3 | 4 | 1 | 1 | 2 | 4 | 11 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 6 | 5 | 1 | 0 | 13 | 2 | +11 | 16 | WWWW | 3 | 3 | 0 | 0 | 9 | 0 | 3 | 2 | 1 | 0 | 4 | 2 | ||
| 2 | 6 | Sporting Kansas City | 7 | 4 | 1 | 2 | 12 | 8 | +4 | 13 | WWLW | 3 | 2 | 1 | 0 | 6 | 2 | 4 | 2 | 0 | 2 | 6 | 6 | |
| 3 | 1 | LA Galaxy | 6 | 4 | 0 | 2 | 10 | 11 | -1 | 12 | LWWL | 3 | 3 | 0 | 0 | 7 | 3 | 3 | 1 | 0 | 2 | 3 | 8 | |
| 4 | 1 | Houston Dynamo | 7 | 3 | 2 | 2 | 9 | 9 | +0 | 11 | WLWX | 4 | 3 | 1 | 0 | 6 | 3 | 3 | 0 | 1 | 2 | 3 | 6 | |
| 5 | 2 | Colorado Rapids | 6 | 3 | 1 | 2 | 9 | 8 | +1 | 10 | LWWW | 3 | 2 | 0 | 1 | 7 | 6 | 3 | 1 | 1 | 1 | 2 | 2 | |
| 6 | 3 | Portland Timbers | 6 | 3 | 0 | 3 | 9 | 8 | +1 | 9 | WWLL | 3 | 2 | 0 | 1 | 6 | 3 | 3 | 1 | 0 | 2 | 3 | 5 | |
| 7 | 3 | San Jose Earthquakes | 7 | 3 | 0 | 4 | 11 | 11 | +0 | 9 | LLLW | 5 | 2 | 0 | 3 | 8 | 8 | 2 | 1 | 0 | 1 | 3 | 3 | |
| 8 | 2 | Real Salt Lake | 5 | 2 | 2 | 1 | 8 | 6 | +2 | 8 | XOLW | 3 | 1 | 1 | 1 | 4 | 3 | 2 | 1 | 1 | 0 | 4 | 3 | |
| 9 | 3 | Los Angeles | 6 | 2 | 2 | 2 | 7 | 7 | +0 | 8 | WLLX | 3 | 2 | 1 | 0 | 5 | 2 | 3 | 0 | 1 | 2 | 2 | 5 | |
| 10 | 3 | Vancouver Whitecaps | 7 | 2 | 1 | 4 | 6 | 9 | -3 | 7 | LLLW | 3 | 2 | 0 | 1 | 3 | 1 | 4 | 0 | 1 | 3 | 3 | 8 | |
| 11 | 1 | Austin FC | 5 | 2 | 0 | 3 | 5 | 7 | -2 | 6 | LLWW | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 3 | 5 | 7 | |
| 12 | 1 | Minnesota United | 6 | 2 | 0 | 4 | 5 | 10 | -5 | 6 | WWLL | 4 | 2 | 0 | 2 | 3 | 3 | 2 | 0 | 0 | 2 | 2 | 7 | |
| 13 | FC Dallas | 6 | 1 | 3 | 2 | 8 | 8 | +0 | 6 | XLXW | 4 | 1 | 3 | 0 | 7 | 4 | 2 | 0 | 0 | 2 | 1 | 4 | ||
| 7 | Javier HERNÁNDEZ (LA Galaxy) | |
| 5 | Raúl RUIDÍAZ (Seattle Sounders, 1p) | |
| 4 | Valentín CASTELLANOS (New York City, 1p) | |
| +3 | Alan PULIDO (Sporting Kansas City, 1p) | |
| +1 | Rubio RUBIN (Real Salt Lake) | |
| Jesús MEDINA (New York City) | ||
| +2 | Gonzalo HIGUAÍN (Inter Miami, 1p) | |
| 3 | +1 | Maximiliano URRUTI (Houston Dynamo) |
| +1 | Brad SMITH (Seattle Sounders) | |
| Cristian DÁJOME (Vancouver Whitecaps, 2p) | ||
| +2 | Lucas ZELARAYÁN (Columbus Crew) | |
| +2 | Adam BUKSA (New England Revolution) | |
| NANI (Orlando City) | ||
| +2 | Dániel SALLÓI (Sporting Kansas City) | |
| Caden CLARK (New York Red Bulls) | ||
| +2 | Diego ROSSI (Los Angeles) | |
| +1 | Luka STOJANOVIĆ (Chicago Fire) |
| Sunday, 16 May 2021 | |||||
| D.C. United | 0-1 | Orlando City | |||
| 7 | Pereyra | ||||
| New England Revolution | 1-0 | Columbus Crew | |||
| 86 | Buksa | ||||
| Sporting Kansas City | 3-0 | Vancouver Whitecaps | |||
| 28 | Sallói | ||||
| 32(p) | Pulido | ||||
| 58 | Pulido | ||||
| Seattle Sounders | 2-0 | Los Angeles | |||
| 57 | Arreaga | ||||
| 73 | Smith | ||||
| FC Cincinnati | 2-3 | Inter Miami | |||
| 59 | Barreal | 7 | Shea | ||
| 82 | Hagglund | 38 | Higuaín | ||
| 85 | Higuaín | ||||
| Saturday, 22 May 2021 | |||||
| FC Dallas | 2-2 | Real Salt Lake | |||
| 43(p) | Jara | 20 | Rubin | ||
| 84 | Hollingshead | 86 | Kreilach | ||
| Houston Dynamo | 2-1 | Vancouver Whitecaps | |||
| 8 | Rodriguez | 80 | Caicedo | ||
| 42 | Urruti | ||||
| New England Revolution | 3-1 | New York Red Bulls | |||
| 36 | Bou | 7 | Reyes | ||
| 45 | Buchanan | ||||
| 82 | Buksa | ||||
| Chicago Fire | 1-0 | Inter Miami | |||
| 69 | Stojanović | ||||
| CF Montréal | 1-2 | FC Cincinnati | |||
| 56 | Mihailovic | 70 | Locadia | ||
| 86 | Vallecilla | ||||
| Portland Timbers | 3-0 | LA Galaxy | |||
| 47 | Mora | ||||
| 60 | Mora | ||||
| 69(p) | Valeri | ||||
| San Jose Earthquakes | 1-3 | Sporting Kansas City | |||
| 4 | López | 15 | Lindsey | ||
| 60 | Pulido | ||||
| 75 | Sallói | ||||
| Orlando City | 1-0 | Toronto FC | |||
| 12 | Akindele | ||||
| Los Angeles | 2-1 | Colorado Rapids | |||
| 14 | Rossi | 50 | Barrios | ||
| 33 | Rossi | ||||
| New York City | 1-2 | Columbus Crew | |||
| 18 | Tajouri-Shradi | 82 | Zelarayán | ||
| 90 | Zelarayán | ||||
