Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 225 | 598 | 2.65 | 104 | 46.22% | 69 | 30.67% | 52 | 23.11% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 18 | 11 | 4 | 3 | 33 | 21 | +12 | 37 | OWWW | 8 | 6 | 1 | 1 | 14 | 8 | 10 | 5 | 3 | 2 | 19 | 13 | ||
| 2 | Orlando City | 17 | 8 | 5 | 4 | 27 | 22 | +5 | 29 | XWLW | 9 | 5 | 3 | 1 | 17 | 7 | 8 | 3 | 2 | 3 | 10 | 15 | ||
| 3 | 2 | Philadelphia Union | 18 | 7 | 7 | 4 | 24 | 17 | +7 | 28 | WXXL | 9 | 5 | 2 | 2 | 13 | 7 | 9 | 2 | 5 | 2 | 11 | 10 | |
| 4 | Nashville | 17 | 6 | 10 | 1 | 25 | 15 | +10 | 28 | OXWO | 11 | 6 | 5 | 0 | 22 | 10 | 6 | 0 | 5 | 1 | 3 | 5 | ||
| 5 | 2 | New York City | 16 | 8 | 3 | 5 | 30 | 16 | +14 | 27 | OWWW | 9 | 6 | 1 | 2 | 22 | 8 | 7 | 2 | 2 | 3 | 8 | 8 | |
| 6 | 2 | D.C. United | 17 | 7 | 3 | 7 | 25 | 20 | +5 | 24 | WOWX | 7 | 5 | 0 | 2 | 12 | 4 | 10 | 2 | 3 | 5 | 13 | 16 | |
| 7 | 1 | Columbus Crew | 17 | 6 | 6 | 5 | 19 | 20 | -1 | 24 | LLWO | 8 | 4 | 3 | 1 | 13 | 9 | 9 | 2 | 3 | 4 | 6 | 11 | |
| 8 | 1 | CF Montréal | 17 | 6 | 5 | 6 | 23 | 22 | +1 | 23 | XLLL | 8 | 4 | 3 | 1 | 15 | 11 | 9 | 2 | 2 | 5 | 8 | 11 | |
| 9 | New York Red Bulls | 16 | 5 | 4 | 7 | 20 | 20 | +0 | 19 | OLLX | 8 | 4 | 2 | 2 | 12 | 7 | 8 | 1 | 2 | 5 | 8 | 13 | ||
| 10 | 2 | FC Cincinnati | 16 | 3 | 6 | 7 | 17 | 29 | -12 | 15 | OOLX | 6 | 0 | 3 | 3 | 5 | 9 | 10 | 3 | 3 | 4 | 12 | 20 | |
| 11 | 1 | Atlanta United | 17 | 2 | 9 | 6 | 18 | 23 | -5 | 15 | XLLX | 7 | 2 | 3 | 2 | 8 | 7 | 10 | 0 | 6 | 4 | 10 | 16 | |
| 12 | 1 | Chicago Fire | 17 | 3 | 5 | 9 | 18 | 28 | -10 | 14 | OXLX | 11 | 3 | 4 | 4 | 15 | 14 | 6 | 0 | 1 | 5 | 3 | 14 | |
| 13 | 2 | Toronto FC | 17 | 3 | 5 | 9 | 21 | 36 | -15 | 14 | LXWX | 7 | 1 | 4 | 2 | 9 | 10 | 10 | 2 | 1 | 7 | 12 | 26 | |
| 14 | Inter Miami | 15 | 3 | 4 | 8 | 13 | 25 | -12 | 13 | XWXL | 8 | 1 | 2 | 5 | 7 | 18 | 7 | 2 | 2 | 3 | 6 | 7 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Sporting Kansas City | 17 | 10 | 3 | 4 | 33 | 20 | +13 | 33 | WLWX | 9 | 5 | 3 | 1 | 17 | 10 | 8 | 5 | 0 | 3 | 16 | 10 | |
| 2 | 1 | Seattle Sounders | 18 | 9 | 6 | 3 | 26 | 14 | +12 | 33 | XLLW | 11 | 5 | 4 | 2 | 18 | 9 | 7 | 4 | 2 | 1 | 8 | 5 | |
| 3 | LA Galaxy | 17 | 10 | 1 | 6 | 28 | 27 | +1 | 31 | WWLX | 9 | 7 | 0 | 2 | 17 | 9 | 8 | 3 | 1 | 4 | 11 | 18 | ||
| 4 | Colorado Rapids | 15 | 8 | 3 | 4 | 22 | 16 | +6 | 27 | WLWX | 8 | 5 | 2 | 1 | 16 | 8 | 7 | 3 | 1 | 3 | 6 | 8 | ||
| 5 | Los Angeles | 17 | 6 | 5 | 6 | 23 | 23 | +0 | 23 | LXXL | 10 | 4 | 4 | 2 | 16 | 14 | 7 | 2 | 1 | 4 | 7 | 9 | ||
| 6 | Minnesota United | 16 | 6 | 5 | 5 | 19 | 21 | -2 | 23 | XXWW | 8 | 5 | 1 | 2 | 10 | 6 | 8 | 1 | 4 | 3 | 9 | 15 | ||
| 7 | Real Salt Lake | 16 | 5 | 6 | 5 | 24 | 17 | +7 | 21 | LOWX | 9 | 3 | 4 | 2 | 14 | 9 | 7 | 2 | 2 | 3 | 10 | 8 | ||
| 8 | Portland Timbers | 16 | 6 | 2 | 8 | 20 | 27 | -7 | 20 | XLLW | 8 | 5 | 1 | 2 | 12 | 7 | 8 | 1 | 1 | 6 | 8 | 20 | ||
| 9 | 1 | FC Dallas | 17 | 4 | 6 | 7 | 21 | 25 | -4 | 18 | XWWL | 8 | 3 | 5 | 0 | 16 | 8 | 9 | 1 | 1 | 7 | 5 | 17 | |
| 10 | 1 | San Jose Earthquakes | 17 | 4 | 6 | 7 | 19 | 26 | -7 | 18 | XWXX | 7 | 2 | 1 | 4 | 10 | 12 | 10 | 2 | 5 | 3 | 9 | 14 | |
| 11 | 2 | Houston Dynamo | 17 | 3 | 9 | 5 | 19 | 23 | -4 | 18 | LOXO | 7 | 3 | 4 | 0 | 9 | 6 | 10 | 0 | 5 | 5 | 10 | 17 | |
| 12 | 1 | Austin FC | 16 | 4 | 4 | 8 | 13 | 18 | -5 | 16 | WLLL | 7 | 2 | 2 | 3 | 7 | 7 | 9 | 2 | 2 | 5 | 6 | 11 | |
| 13 | 1 | Vancouver Whitecaps | 16 | 3 | 6 | 7 | 18 | 27 | -9 | 15 | XXOW | 8 | 3 | 2 | 3 | 8 | 10 | 8 | 0 | 4 | 4 | 10 | 17 | |
| 11 | Raúl RUIDÍAZ (Seattle Sounders, 2p) | |
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| +1 | Dániel SALLÓI (Sporting Kansas City) | |
| +1 | Gustavo BOU (New England Revolution) | |
| 9 | +2 | Ola KAMARA (D.C. United, 3p) |
| 8 | +2 | Cristian DÁJOME (Vancouver Whitecaps, 3p) |
| +1 | Adam BUKSA (New England Revolution) | |
| NANI (Orlando City, 2p) | ||
| Ricardo PEPI (FC Dallas) | ||
| 7 | +1 | Mason TOYE (CF Montréal, 2p) |
| Hany MUKHTAR (Nashville, 1p) | ||
| +1 | Alan PULIDO (Sporting Kansas City, 2p) | |
| Damir KREILACH (Real Salt Lake) | ||
| Jesús MEDINA (New York City) | ||
| +2 | Gonzalo HIGUAÍN (Inter Miami, 2p) | |
| 6 | Maximiliano URRUTI (Houston Dynamo) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Valentín CASTELLANOS (New York City, 1p) | ||
| +1 | Lucas ZELARAYÁN (Columbus Crew) | |
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| 5 | +1 | Marcelino MORENO (Atlanta United, 2p) |
| Carlos VELA (Los Angeles) | ||
| Diego ROSSI (Los Angeles) | ||
| Rubio RUBIN (Real Salt Lake) | ||
| +1 | Felipe MORA (Portland Timbers) | |
| C.J. SAPONG (Nashville) | ||
| +1 | Robin LOD (Minnesota United) | |
| José CIFUENTES (Los Angeles) |
| Saturday, 31 July 2021 | |||||
| Houston Dynamo | 0-0 | Real Salt Lake | |||
| New York Red Bulls | 2-3 | New England Revolution | |||
| 8 | Carmona | 60 | Bou | ||
| 63 | Fábio | 84 | Bye | ||
| 90 | Buksa | ||||
| Sporting Kansas City | 1-2 | FC Dallas | |||
| 85 | Russell | 3 | Pomykal | ||
| 51 | Ferreira | ||||
| Vancouver Whitecaps | 2-2 | Minnesota United | |||
| 36 | Dájome | 45 | Finlay | ||
| 90(p) | Dájome | 75 | Lod | ||
| Seattle Sounders | 0-1 | San Jose Earthquakes | |||
| 45 | Espinoza | ||||
| Austin FC | 0-1 | Colorado Rapids | |||
| 29 | André Bava | ||||
| FC Cincinnati | 0-0 | D.C. United | |||
| Inter Miami | 2-1 | CF Montréal | |||
| 49(p) | Higuaín | 20 | Torres | ||
| 69 | Higuaín | ||||
| Sunday, 1 August 2021 | |||||
| Toronto FC | 1-1 | Nashville | |||
| 20 | González | 41 | Castellanos | ||
| Philadelphia Union | 1-1 | Chicago Fire | |||
| 36 | Wagner | 10 | Frankowski | ||
| Wednesday, 4 August 2021 | |||||
| New York Red Bulls | 0-0 | FC Cincinnati | |||
| Columbus Crew | 2-4 | D.C. United | |||
| 65 | Molino | 19 | Kamara | ||
| 71 | Zelarayán | 40 | Reyna | ||
| 45(p) | Kamara | ||||
| 74 | Reyna | ||||
| New England Revolution | 0-0 | Nashville | |||
| LA Galaxy | 1-0 | Real Salt Lake | |||
| 53 | Álvarez | ||||
| Chicago Fire | 0-0 | New York City | |||
| CF Montréal | 2-2 | Atlanta United | |||
| 53 | Toye | 65 | Martínez | ||
| 63 | Camacho | 76(p) | Moreno | ||
| Portland Timbers | 1-1 | San Jose Earthquakes | |||
| 45 | Mora | 24 | López | ||
| Seattle Sounders | 1-1 | FC Dallas | |||
| 72 | Montero | 90 | Jara | ||
| Orlando City | 1-1 | Inter Miami | |||
| 45 | Antônio Carlos | 66 | Gibbs | ||
| Philadelphia Union | 3-0 | Toronto FC | |||
| 12 | Glesnes | ||||
| 33(p) | Gazdag | ||||
| 36 | Santos | ||||
| Los Angeles | 1-4 | Sporting Kansas City | |||
| 82 | Musovski | 20 | Pulido | ||
| 28 | Luís Martins | ||||
| 36 | Sallói | ||||
| 58 | Kinda | ||||
| Austin FC | 3-2 | Houston Dynamo | |||
| 7 | Pochettino | 27 | Pasher | ||
| 45 | Pochettino | 86 | Picault | ||
| 56 | Domínguez | ||||
