Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 67 | 168 | 2.50 | 35 | 52.24% | 18 | 26.87% | 14 | 20.90% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York City | 5 | 2 | 2 | 1 | 10 | 4 | +6 | 8 | XXWW | 2 | 1 | 1 | 0 | 6 | 1 | 3 | 1 | 1 | 1 | 4 | 3 | ||
| 2 | 5 | Atlanta United | 5 | 2 | 2 | 1 | 6 | 4 | +2 | 8 | WXLW | 2 | 2 | 0 | 0 | 4 | 1 | 3 | 0 | 2 | 1 | 2 | 3 | |
| 3 | 5 | CF Montréal | 6 | 2 | 2 | 2 | 8 | 7 | +1 | 8 | LWLO | 2 | 1 | 1 | 0 | 4 | 2 | 4 | 1 | 1 | 2 | 4 | 5 | |
| 4 | 2 | New England Revolution | 5 | 2 | 2 | 1 | 6 | 6 | +0 | 8 | XLWW | 2 | 2 | 0 | 0 | 3 | 1 | 3 | 0 | 2 | 1 | 3 | 5 | |
| 5 | 5 | Philadelphia Union | 6 | 2 | 2 | 2 | 5 | 5 | +0 | 8 | WXWL | 4 | 1 | 1 | 2 | 3 | 5 | 2 | 1 | 1 | 0 | 2 | 0 | |
| 6 | 1 | Nashville | 5 | 1 | 4 | 0 | 6 | 4 | +2 | 7 | OWOX | 4 | 1 | 3 | 0 | 6 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | |
| 7 | 4 | New York Red Bulls | 5 | 2 | 0 | 3 | 7 | 6 | +1 | 6 | LWWL | 3 | 2 | 0 | 1 | 5 | 2 | 2 | 0 | 0 | 2 | 2 | 4 | |
| 8 | 3 | D.C. United | 5 | 2 | 0 | 3 | 5 | 9 | -4 | 6 | WLLL | 2 | 2 | 0 | 0 | 3 | 1 | 3 | 0 | 0 | 3 | 2 | 8 | |
| 9 | 5 | Orlando City | 4 | 1 | 3 | 0 | 5 | 2 | +3 | 6 | XWXO | 3 | 1 | 2 | 0 | 4 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | |
| 10 | 4 | Columbus Crew | 4 | 1 | 2 | 1 | 3 | 3 | +0 | 5 | LWOO | 2 | 1 | 1 | 0 | 3 | 1 | 2 | 0 | 1 | 1 | 0 | 2 | |
| 11 | 1 | Toronto FC | 5 | 1 | 2 | 2 | 7 | 9 | -2 | 5 | XWLX | 2 | 1 | 1 | 0 | 4 | 2 | 3 | 0 | 1 | 2 | 3 | 7 | |
| 12 | 3 | Inter Miami | 5 | 1 | 2 | 2 | 5 | 7 | -2 | 5 | LXOW | 3 | 0 | 1 | 2 | 3 | 6 | 2 | 1 | 1 | 0 | 2 | 1 | |
| 13 | Chicago Fire | 5 | 0 | 1 | 4 | 3 | 10 | -7 | 1 | LLLL | 2 | 0 | 1 | 1 | 2 | 4 | 3 | 0 | 0 | 3 | 1 | 6 | ||
| 14 | FC Cincinnati | 3 | 0 | 1 | 2 | 2 | 10 | -8 | 1 | LLX- | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 2 | 2 | 10 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 5 | 4 | 1 | 0 | 11 | 2 | +9 | 13 | WWWX | 2 | 2 | 0 | 0 | 7 | 0 | 3 | 2 | 1 | 0 | 4 | 2 | ||
| 2 | 1 | LA Galaxy | 5 | 4 | 0 | 1 | 10 | 8 | +2 | 12 | WWLW | 3 | 3 | 0 | 0 | 7 | 3 | 2 | 1 | 0 | 1 | 3 | 5 | |
| 3 | 3 | Colorado Rapids | 5 | 3 | 1 | 1 | 8 | 6 | +2 | 10 | WWWL | 3 | 2 | 0 | 1 | 7 | 6 | 2 | 1 | 1 | 0 | 1 | 0 | |
| 4 | 2 | San Jose Earthquakes | 6 | 3 | 0 | 3 | 10 | 8 | +2 | 9 | LLWW | 4 | 2 | 0 | 2 | 7 | 5 | 2 | 1 | 0 | 1 | 3 | 3 | |
| 5 | 6 | Houston Dynamo | 6 | 2 | 2 | 2 | 7 | 8 | -1 | 8 | LWXX | 3 | 2 | 1 | 0 | 4 | 2 | 3 | 0 | 1 | 2 | 3 | 6 | |
| 6 | 1 | Real Salt Lake | 4 | 2 | 1 | 1 | 6 | 4 | +2 | 7 | OLWW | 3 | 1 | 1 | 1 | 4 | 3 | 1 | 1 | 0 | 0 | 2 | 1 | |
| 7 | 3 | Vancouver Whitecaps | 5 | 2 | 1 | 2 | 5 | 4 | +1 | 7 | LWLX | 3 | 2 | 0 | 1 | 3 | 1 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 8 | 3 | Sporting Kansas City | 5 | 2 | 1 | 2 | 6 | 7 | -1 | 7 | LWLX | 2 | 1 | 1 | 0 | 3 | 2 | 3 | 1 | 0 | 2 | 3 | 5 | |
| 9 | 3 | Portland Timbers | 5 | 2 | 0 | 3 | 6 | 8 | -2 | 6 | WLLW | 2 | 1 | 0 | 1 | 3 | 3 | 3 | 1 | 0 | 2 | 3 | 5 | |
| 10 | 2 | Austin FC | 5 | 2 | 0 | 3 | 5 | 7 | -2 | 6 | LLWW | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 3 | 5 | 7 | |
| 11 | 2 | Minnesota United | 6 | 2 | 0 | 4 | 5 | 10 | -5 | 6 | WWLL | 4 | 2 | 0 | 2 | 3 | 3 | 2 | 0 | 0 | 2 | 2 | 7 | |
| 12 | 2 | Los Angeles | 4 | 1 | 2 | 1 | 5 | 4 | +1 | 5 | LXXW | 2 | 1 | 1 | 0 | 3 | 1 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 13 | 4 | FC Dallas | 5 | 1 | 2 | 2 | 6 | 6 | +0 | 5 | LXWL | 3 | 1 | 2 | 0 | 5 | 2 | 2 | 0 | 0 | 2 | 1 | 4 | |
| 7 | +1 | Javier HERNÁNDEZ (LA Galaxy) |
| 5 | Raúl RUIDÍAZ (Seattle Sounders, 1p) | |
| 4 | Valentín CASTELLANOS (New York City, 1p) | |
| +1 | Jesús MEDINA (New York City) | |
| 3 | Cristian DÁJOME (Vancouver Whitecaps, 2p) | |
| NANI (Orlando City) | ||
| Caden CLARK (New York Red Bulls) | ||
| Rubio RUBIN (Real Salt Lake) |
| Wednesday, 12 May 2021 | |||||
| Houston Dynamo | 1-0 | Sporting Kansas City | |||
| 56 | Urruti | ||||
| Toronto FC | 2-0 | Columbus Crew | |||
| 13 | Bradley | ||||
| 87 | Altidore | ||||
| San Jose Earthquakes | 0-1 | Seattle Sounders | |||
| 18 | Roldan | ||||
| Philadelphia Union | 1-1 | New England Revolution | |||
| 88 | Przybyłko | 85 | Bunbury | ||
| Minnesota United | 1-0 | Vancouver Whitecaps | |||
| 72 | Ábila | ||||
| Inter Miami | 0-2 | CF Montréal | |||
| 14 | Johnsen | ||||
| 25 | Johnsen | ||||
| Thursday, 13 May 2021 | |||||
| D.C. United | 1-0 | Chicago Fire | |||
| 7 | Flores | ||||
| Saturday, 15 May 2021 | |||||
| Colorado Rapids | 3-1 | Houston Dynamo | |||
| 29 | Vines | 39 | Ramirez | ||
| 36 | Rubio | ||||
| 42 | Bassett | ||||
| LA Galaxy | 2-0 | Austin FC | |||
| 35 | Lletget | ||||
| 77 | Hernández | ||||
| Real Salt Lake | 0-0 | Nashville | |||
| San Jose Earthquakes | 0-2 | Portland Timbers | |||
| 5 | Chará | ||||
| 74 | Loría | ||||
| Philadelphia Union | 1-0 | New York Red Bulls | |||
| 9 | Burke | ||||
| Minnesota United | 1-0 | FC Dallas | |||
| 90 | Lod | ||||
| New York City | 1-1 | Toronto FC | |||
| 53 | Medina | 74 | Shaffelburg | ||
| Atlanta United | 1-0 | CF Montréal | |||
| 90 | Moreno | ||||
