Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 111 | 278 | 2.50 | 56 | 50.45% | 27 | 24.32% | 28 | 25.23% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 9 | 6 | 2 | 1 | 14 | 9 | +5 | 20 | WWWW | 4 | 4 | 0 | 0 | 7 | 2 | 5 | 2 | 2 | 1 | 7 | 7 | ||
| 2 | Orlando City | 8 | 4 | 3 | 1 | 11 | 6 | +5 | 15 | WLWW | 4 | 2 | 2 | 0 | 5 | 1 | 4 | 2 | 1 | 1 | 6 | 5 | ||
| 3 | 3 | Philadelphia Union | 8 | 4 | 2 | 2 | 9 | 5 | +4 | 14 | WWWX | 5 | 2 | 1 | 2 | 6 | 5 | 3 | 2 | 1 | 0 | 3 | 0 | |
| 4 | 1 | Columbus Crew | 8 | 4 | 2 | 2 | 9 | 6 | +3 | 14 | WWWL | 4 | 3 | 1 | 0 | 7 | 2 | 4 | 1 | 1 | 2 | 2 | 4 | |
| 5 | 4 | New York Red Bulls | 8 | 4 | 0 | 4 | 12 | 10 | +2 | 12 | WWLL | 5 | 4 | 0 | 1 | 9 | 3 | 3 | 0 | 0 | 3 | 3 | 7 | |
| 6 | 4 | D.C. United | 9 | 4 | 0 | 5 | 9 | 11 | -2 | 12 | WWLL | 5 | 3 | 0 | 2 | 4 | 3 | 4 | 1 | 0 | 3 | 5 | 8 | |
| 7 | 4 | New York City | 8 | 3 | 2 | 3 | 15 | 10 | +5 | 11 | LWLX | 4 | 1 | 1 | 2 | 9 | 6 | 4 | 2 | 1 | 1 | 6 | 4 | |
| 8 | 4 | CF Montréal | 8 | 3 | 2 | 3 | 10 | 9 | +1 | 11 | WLLW | 3 | 1 | 1 | 1 | 5 | 4 | 5 | 2 | 1 | 2 | 5 | 5 | |
| 9 | 2 | Nashville | 8 | 2 | 5 | 1 | 9 | 8 | +1 | 11 | LXWO | 5 | 2 | 3 | 0 | 7 | 4 | 3 | 0 | 2 | 1 | 2 | 4 | |
| 10 | 2 | Atlanta United | 7 | 2 | 4 | 1 | 9 | 7 | +2 | 10 | XXWX | 3 | 2 | 1 | 0 | 6 | 3 | 4 | 0 | 3 | 1 | 3 | 4 | |
| 11 | Inter Miami | 9 | 2 | 2 | 5 | 8 | 14 | -6 | 8 | LLLW | 4 | 0 | 1 | 3 | 3 | 9 | 5 | 2 | 1 | 2 | 5 | 5 | ||
| 12 | Toronto FC | 8 | 1 | 2 | 5 | 10 | 15 | -5 | 5 | LLLX | 3 | 1 | 1 | 1 | 6 | 5 | 5 | 0 | 1 | 4 | 4 | 10 | ||
| 13 | Chicago Fire | 8 | 1 | 1 | 6 | 4 | 13 | -9 | 4 | LLWL | 4 | 1 | 1 | 2 | 3 | 5 | 4 | 0 | 0 | 4 | 1 | 8 | ||
| 14 | FC Cincinnati | 7 | 1 | 1 | 5 | 6 | 17 | -11 | 4 | LLWL | 3 | 0 | 0 | 3 | 2 | 6 | 4 | 1 | 1 | 2 | 4 | 11 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 9 | 6 | 3 | 0 | 16 | 4 | +12 | 21 | WOXW | 5 | 3 | 2 | 0 | 10 | 1 | 4 | 3 | 1 | 0 | 6 | 3 | ||
| 2 | Sporting Kansas City | 10 | 5 | 2 | 3 | 17 | 13 | +4 | 17 | LXWW | 5 | 3 | 2 | 0 | 10 | 5 | 5 | 2 | 0 | 3 | 7 | 8 | ||
| 3 | 1 | Colorado Rapids | 8 | 5 | 1 | 2 | 14 | 8 | +6 | 16 | WWLW | 4 | 3 | 0 | 1 | 10 | 6 | 4 | 2 | 1 | 1 | 4 | 2 | |
| 4 | 1 | LA Galaxy | 8 | 5 | 0 | 3 | 12 | 13 | -1 | 15 | LWLW | 5 | 4 | 0 | 1 | 9 | 5 | 3 | 1 | 0 | 2 | 3 | 8 | |
| 5 | 1 | Portland Timbers | 8 | 4 | 0 | 4 | 11 | 12 | -1 | 12 | WLWW | 4 | 3 | 0 | 1 | 8 | 4 | 4 | 1 | 0 | 3 | 3 | 8 | |
| 6 | 2 | Real Salt Lake | 7 | 3 | 3 | 1 | 12 | 8 | +4 | 12 | WXXO | 5 | 2 | 2 | 1 | 8 | 5 | 2 | 1 | 1 | 0 | 4 | 3 | |
| 7 | 2 | Houston Dynamo | 9 | 3 | 3 | 3 | 12 | 13 | -1 | 12 | XLWL | 4 | 3 | 1 | 0 | 6 | 3 | 5 | 0 | 2 | 3 | 6 | 10 | |
| 8 | 1 | San Jose Earthquakes | 9 | 3 | 1 | 5 | 11 | 12 | -1 | 10 | OLLL | 5 | 2 | 0 | 3 | 8 | 8 | 4 | 1 | 1 | 2 | 3 | 4 | |
| 9 | Los Angeles | 8 | 2 | 3 | 3 | 9 | 10 | -1 | 9 | XLWL | 5 | 2 | 2 | 1 | 7 | 5 | 3 | 0 | 1 | 2 | 2 | 5 | ||
| 10 | 2 | Austin FC | 9 | 2 | 3 | 4 | 6 | 9 | -3 | 9 | OXOL | 1 | 0 | 1 | 0 | 0 | 0 | 8 | 2 | 2 | 4 | 6 | 9 | |
| 11 | Minnesota United | 8 | 2 | 2 | 4 | 7 | 12 | -5 | 8 | XXWW | 4 | 2 | 0 | 2 | 3 | 3 | 4 | 0 | 2 | 2 | 4 | 9 | ||
| 12 | 2 | Vancouver Whitecaps | 8 | 2 | 1 | 5 | 7 | 12 | -5 | 7 | LLLL | 3 | 2 | 0 | 1 | 3 | 1 | 5 | 0 | 1 | 4 | 4 | 11 | |
| 13 | FC Dallas | 8 | 1 | 4 | 3 | 9 | 12 | -3 | 7 | XLXL | 5 | 1 | 4 | 0 | 8 | 5 | 3 | 0 | 0 | 3 | 1 | 7 | ||
| 7 | +1 | Raúl RUIDÍAZ (Seattle Sounders, 1p) |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| 5 | +1 | Maximiliano URRUTI (Houston Dynamo) |
| Alan PULIDO (Sporting Kansas City, 2p) | ||
| +2 | Damir KREILACH (Real Salt Lake) | |
| Jesús MEDINA (New York City) | ||
| 4 | Valentín CASTELLANOS (New York City, 1p) | |
| Adam BUKSA (New England Revolution) | ||
| +1 | Ola KAMARA (D.C. United, 1p) | |
| +1 | NANI (Orlando City) | |
| +1 | Dániel SALLÓI (Sporting Kansas City) | |
| Caden CLARK (New York Red Bulls) | ||
| Rubio RUBIN (Real Salt Lake) | ||
| Gonzalo HIGUAÍN (Inter Miami, 1p) |
| Sunday, 30 May 2021 | |||||
| Seattle Sounders | 0-0 | Austin FC | |||
| Philadelphia Union | 3-0 | Portland Timbers | |||
| 26 | Przybyłko | ||||
| 31 | Santos | ||||
| 63 | Elliott | ||||
| Saturday, 12 June 2021 | |||||
| Sporting Kansas City | 1-1 | Austin FC | |||
| 71 | Sallói | 26 | Domínguez | ||
| Friday, 18 June 2021 | |||||
| New York Red Bulls | 2-0 | Nashville | |||
| 37 | Fábio | ||||
| 56 | Duncan | ||||
| Real Salt Lake | 3-1 | Vancouver Whitecaps | |||
| 43 | Kreilach | 54 | White | ||
| 90 | Holt | ||||
| 90 | Kreilach | ||||
| Saturday, 19 June 2021 | |||||
| D.C. United | 1-0 | Inter Miami | |||
| 72(p) | Kamara | ||||
| FC Dallas | 1-1 | Minnesota United | |||
| 68 | Pepi | 36 | Fragapane | ||
| Columbus Crew | 2-0 | Chicago Fire | |||
| 17 | Zardes | ||||
| 34 | Zardes | ||||
| LA Galaxy | 1-2 | Seattle Sounders | |||
| 21(p) | Kljestan | 41 | Gómez | ||
| 49 | Ruidíaz | ||||
| Portland Timbers | 2-1 | Sporting Kansas City | |||
| 36 | Asprilla | 28 | Lindsey | ||
| 45 | Loría | ||||
| Toronto FC | 2-3 | Orlando City | |||
| 10 | Akinola | 1 | Akindele | ||
| 39 | Osorio | 8 | Nani | ||
| 84 | Júnior Urso | ||||
| Los Angeles | 1-1 | Houston Dynamo | |||
| 50 | Cifuentes | 58 | Urruti | ||
| Austin FC | 0-0 | San Jose Earthquakes | |||
| New York City | 2-3 | New England Revolution | |||
| 55 | Thiago Andrade | 27 | Bou | ||
| 85 | Tajouri-Shradi | 78 | Bell | ||
| 88 | McNamara | ||||
| FC Cincinnati | 0-2 | Colorado Rapids | |||
| 21 | Rubio | ||||
| 72 | Lewis | ||||
