Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 405 | 1,125 | 2.77 | 196 | 48.40% | 108 | 26.67% | 101 | 24.94% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 31 | 21 | 6 | 4 | 62 | 38 | +24 | 69 | WXWW | 15 | 11 | 3 | 1 | 30 | 17 | 16 | 10 | 3 | 3 | 32 | 21 | ||
| 2 | Nashville | 30 | 11 | 16 | 3 | 47 | 27 | +20 | 49 | XOOX | 16 | 8 | 8 | 0 | 34 | 17 | 14 | 3 | 8 | 3 | 13 | 10 | ||
| 3 | Philadelphia Union | 30 | 12 | 10 | 8 | 42 | 32 | +10 | 46 | LXWW | 15 | 9 | 3 | 3 | 22 | 10 | 15 | 3 | 7 | 5 | 20 | 22 | ||
| 4 | Orlando City | 30 | 12 | 10 | 8 | 43 | 42 | +1 | 46 | XWWX | 15 | 8 | 5 | 2 | 26 | 15 | 15 | 4 | 5 | 6 | 17 | 27 | ||
| 5 | Atlanta United | 30 | 11 | 10 | 9 | 40 | 34 | +6 | 43 | XWLW | 15 | 8 | 4 | 3 | 22 | 12 | 15 | 3 | 6 | 6 | 18 | 22 | ||
| 6 | 1 | CF Montréal | 30 | 11 | 9 | 10 | 43 | 40 | +3 | 42 | XXWL | 15 | 8 | 4 | 3 | 27 | 21 | 15 | 3 | 5 | 7 | 16 | 19 | |
| 7 | 1 | D.C. United | 30 | 12 | 5 | 13 | 51 | 44 | +7 | 41 | LOLW | 15 | 10 | 1 | 4 | 30 | 14 | 15 | 2 | 4 | 9 | 21 | 30 | |
| 8 | New York City | 30 | 11 | 8 | 11 | 45 | 34 | +11 | 41 | XLOL | 14 | 8 | 3 | 3 | 29 | 12 | 16 | 3 | 5 | 8 | 16 | 22 | ||
| 9 | New York Red Bulls | 29 | 11 | 7 | 11 | 35 | 30 | +5 | 40 | WWWX | 15 | 7 | 5 | 3 | 18 | 11 | 14 | 4 | 2 | 8 | 17 | 19 | ||
| 10 | Columbus Crew | 30 | 10 | 8 | 12 | 37 | 40 | -3 | 38 | XWLW | 14 | 8 | 3 | 3 | 27 | 18 | 16 | 2 | 5 | 9 | 10 | 22 | ||
| 11 | Inter Miami | 30 | 10 | 5 | 15 | 28 | 47 | -19 | 35 | WLLL | 15 | 6 | 2 | 7 | 20 | 31 | 15 | 4 | 3 | 8 | 8 | 16 | ||
| 12 | Chicago Fire | 31 | 8 | 7 | 16 | 35 | 51 | -16 | 31 | WXLW | 16 | 6 | 5 | 5 | 22 | 18 | 15 | 2 | 2 | 11 | 13 | 33 | ||
| 13 | Toronto FC | 30 | 6 | 7 | 17 | 34 | 59 | -25 | 25 | LLWW | 14 | 4 | 5 | 5 | 20 | 21 | 16 | 2 | 2 | 12 | 14 | 38 | ||
| 14 | FC Cincinnati | 30 | 4 | 8 | 18 | 32 | 59 | -27 | 20 | LLLL | 15 | 1 | 5 | 9 | 13 | 21 | 15 | 3 | 3 | 9 | 19 | 38 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 30 | 17 | 7 | 6 | 50 | 26 | +24 | 58 | XLWW | 15 | 8 | 4 | 3 | 26 | 12 | 15 | 9 | 3 | 3 | 24 | 14 | ||
| 2 | Sporting Kansas City | 29 | 15 | 7 | 7 | 52 | 33 | +19 | 52 | LWWL | 15 | 8 | 5 | 2 | 30 | 16 | 14 | 7 | 2 | 5 | 22 | 17 | ||
| 3 | Colorado Rapids | 30 | 14 | 10 | 6 | 43 | 32 | +11 | 52 | XLWL | 15 | 7 | 7 | 1 | 24 | 12 | 15 | 7 | 3 | 5 | 19 | 20 | ||
| 4 | Portland Timbers | 30 | 14 | 4 | 12 | 48 | 49 | -1 | 46 | LLWW | 15 | 9 | 2 | 4 | 30 | 22 | 15 | 5 | 2 | 8 | 18 | 27 | ||
| 5 | 1 | LA Galaxy | 30 | 13 | 6 | 11 | 44 | 46 | -2 | 45 | WWXL | 15 | 8 | 3 | 4 | 24 | 17 | 15 | 5 | 3 | 7 | 20 | 29 | |
| 6 | 1 | Minnesota United | 30 | 12 | 8 | 10 | 35 | 37 | -2 | 44 | WWLO | 15 | 9 | 2 | 4 | 21 | 12 | 15 | 3 | 6 | 6 | 14 | 25 | |
| 7 | 2 | Vancouver Whitecaps | 30 | 11 | 10 | 9 | 40 | 41 | -1 | 43 | WWLW | 15 | 9 | 2 | 4 | 22 | 15 | 15 | 2 | 8 | 5 | 18 | 26 | |
| 8 | 3 | Real Salt Lake | 29 | 12 | 6 | 11 | 48 | 45 | +3 | 42 | WLWL | 15 | 9 | 4 | 2 | 26 | 14 | 14 | 3 | 2 | 9 | 22 | 31 | |
| 9 | 1 | Los Angeles | 30 | 11 | 7 | 12 | 46 | 44 | +2 | 40 | WWXL | 15 | 7 | 5 | 3 | 30 | 22 | 15 | 4 | 2 | 9 | 16 | 22 | |
| 10 | San Jose Earthquakes | 30 | 9 | 9 | 12 | 40 | 47 | -7 | 36 | WLLL | 15 | 5 | 3 | 7 | 23 | 22 | 15 | 4 | 6 | 5 | 17 | 25 | ||
| 11 | Houston Dynamo | 31 | 6 | 12 | 13 | 35 | 49 | -14 | 30 | LWLO | 16 | 6 | 6 | 4 | 21 | 21 | 15 | 0 | 6 | 9 | 14 | 28 | ||
| 12 | FC Dallas | 30 | 6 | 10 | 14 | 41 | 50 | -9 | 28 | LOLL | 15 | 4 | 7 | 4 | 22 | 18 | 15 | 2 | 3 | 10 | 19 | 32 | ||
| 13 | Austin FC | 30 | 7 | 4 | 19 | 29 | 49 | -20 | 25 | LLWL | 15 | 5 | 2 | 8 | 22 | 23 | 15 | 2 | 2 | 11 | 7 | 26 | ||
| 17 | Ola KAMARA (D.C. United, 8p) | |
| 16 | Raúl RUIDÍAZ (Seattle Sounders, 3p) | |
| Dániel SALLÓI (Sporting Kansas City) | ||
| 15 | +1 | Gustavo BOU (New England Revolution, 1p) |
| 14 | +1 | Hany MUKHTAR (Nashville, 1p) |
| +1 | Adam BUKSA (New England Revolution) | |
| Damir KREILACH (Real Salt Lake) | ||
| 13 | Valentín CASTELLANOS (New York City, 3p) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Ricardo PEPI (FC Dallas) | ||
| 12 | +1 | Javier LÓPEZ (San Jose Earthquakes, 1p) |
| 11 | +3 | Cristian ARANGO (Los Angeles, 5p) |
| +1 | Brian WHITE (Vancouver Whitecaps) | |
| Fabrice PICAULT (Houston Dynamo, 3p) | ||
| +1 | Johnny RUSSELL (Sporting Kansas City, 3p) | |
| Felipe MORA (Portland Timbers, 1p) | ||
| 10 | Kacper PRZYBYŁKO (Philadelphia Union, 1p) | |
| C.J. SAPONG (Nashville) | ||
| Josef MARTÍNEZ (Atlanta United, 2p) | ||
| Gonzalo HIGUAÍN (Inter Miami, 2p) | ||
| 9 | +1 | Cristian DÁJOME (Vancouver Whitecaps, 4p) |
| +1 | Marcelino MORENO (Atlanta United, 3p) | |
| NANI (Orlando City, 2p) | ||
| Gyasi ZARDES (Columbus Crew) | ||
| +1 | Dairon ASPRILLA (Portland Timbers, 1p) |
| Sunday, 17 October 2021 | |||||
| New York Red Bulls | 1-0 | New York City | |||
| 3 | Cásseres | ||||
| Vancouver Whitecaps | 2-1 | Sporting Kansas City | |||
| 23 | Gauld | 43 | Russell | ||
| 36 | Teibert | ||||
| Wednesday, 20 October 2021 | |||||
| D.C. United | 2-3 | New England Revolution | |||
| 51 | Robertha | 61 | Buksa | ||
| 90 | Ábila | 64 | Carles Gil | ||
| 79 | Bou | ||||
| FC Dallas | 2-3 | Los Angeles | |||
| 10 | Hollingshead | 33(p) | Arango | ||
| 45 | Jara | 75 | Arango | ||
| 79 | Arango | ||||
| Houston Dynamo | 0-3 | LA Galaxy | |||
| 39(p) | Kljestan | ||||
| 45(og) | Valentin | ||||
| 47 | Cabral | ||||
| Colorado Rapids | 1-1 | Seattle Sounders | |||
| 66 | Badji | 81 | Roldan | ||
| Portland Timbers | 2-3 | Vancouver Whitecaps | |||
| 15 | Chará | 63 | Caicedo | ||
| 42 | Asprilla | 75 | White | ||
| 82(p) | Dájome | ||||
| San Jose Earthquakes | 4-0 | Austin FC | |||
| 47 | López | ||||
| 53 | Kikanovic | ||||
| 59 | Wondolowski | ||||
| 85 | Fierro | ||||
| Orlando City | 1-1 | CF Montréal | |||
| 45 | Mueller | 51 | Camacho | ||
| Minnesota United | 3-2 | Philadelphia Union | |||
| 41 | Hunou | 45 | Gazdag | ||
| 63 | Lod | 54 | Gazdag | ||
| 67 | Fragapane | ||||
| Nashville | 1-1 | Columbus Crew | |||
| 77 | Mukhtar | 75 | Zelarayán | ||
| Atlanta United | 1-1 | New York City | |||
| 17 | Moreno | 90 | Þórarinsson | ||
| FC Cincinnati | 3-4 | Chicago Fire | |||
| 28 | Acosta | 14 | Berić | ||
| 36 | Vázquez | 17 | Berić | ||
| 90 | Blackett | 71 | Medrán | ||
| 90 | Stojanović | ||||
| Inter Miami | 3-0 | Toronto FC | |||
| 10 | Higuaín | ||||
| 45 | Makoun | ||||
| 61(og) | Zavaleta | ||||
