Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 459 | 1,281 | 2.79 | 220 | 47.93% | 124 | 27.02% | 115 | 25.05% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 34 | 22 | 7 | 5 | 65 | 41 | +24 | 73 | LWXW | 17 | 12 | 3 | 2 | 31 | 18 | 17 | 10 | 4 | 3 | 34 | 23 | ||
| 2 | 1 | Philadelphia Union | 34 | 14 | 12 | 8 | 48 | 35 | +13 | 54 | XWXW | 17 | 11 | 3 | 3 | 25 | 10 | 17 | 3 | 9 | 5 | 23 | 25 | |
| 3 | 1 | Nashville | 34 | 12 | 18 | 4 | 55 | 33 | +22 | 54 | XXWL | 17 | 8 | 9 | 0 | 35 | 18 | 17 | 4 | 9 | 4 | 20 | 15 | |
| 4 | New York City | 34 | 14 | 9 | 11 | 56 | 36 | +20 | 51 | XWWW | 17 | 10 | 4 | 3 | 37 | 13 | 17 | 4 | 5 | 8 | 19 | 23 | ||
| 5 | 1 | Atlanta United | 34 | 13 | 12 | 9 | 45 | 37 | +8 | 51 | WOXW | 17 | 9 | 5 | 3 | 25 | 14 | 17 | 4 | 7 | 6 | 20 | 23 | |
| 6 | 1 | Orlando City | 34 | 13 | 12 | 9 | 50 | 48 | +2 | 51 | WXLX | 17 | 8 | 7 | 2 | 29 | 18 | 17 | 5 | 5 | 7 | 21 | 30 | |
| 7 | 1 | New York Red Bulls | 34 | 13 | 9 | 12 | 39 | 33 | +6 | 48 | XOWL | 17 | 8 | 6 | 3 | 19 | 11 | 17 | 5 | 3 | 9 | 20 | 22 | |
| 8 | 1 | D.C. United | 34 | 14 | 5 | 15 | 56 | 54 | +2 | 47 | WLWL | 17 | 11 | 1 | 5 | 32 | 17 | 17 | 3 | 4 | 10 | 24 | 37 | |
| 9 | 1 | Columbus Crew | 34 | 13 | 8 | 13 | 46 | 45 | +1 | 47 | WWWL | 17 | 10 | 3 | 4 | 33 | 22 | 17 | 3 | 5 | 9 | 13 | 23 | |
| 10 | 1 | CF Montréal | 34 | 12 | 10 | 12 | 46 | 44 | +2 | 46 | LWLX | 17 | 9 | 4 | 4 | 29 | 23 | 17 | 3 | 6 | 8 | 17 | 21 | |
| 11 | Inter Miami | 34 | 12 | 5 | 17 | 36 | 53 | -17 | 41 | WLLW | 17 | 7 | 2 | 8 | 26 | 35 | 17 | 5 | 3 | 9 | 10 | 18 | ||
| 12 | Chicago Fire | 34 | 9 | 7 | 18 | 36 | 54 | -18 | 34 | LLWW | 17 | 7 | 5 | 5 | 23 | 18 | 17 | 2 | 2 | 13 | 13 | 36 | ||
| 13 | Toronto FC | 34 | 6 | 10 | 18 | 39 | 66 | -27 | 28 | LXXX | 17 | 4 | 7 | 6 | 24 | 27 | 17 | 2 | 3 | 12 | 15 | 39 | ||
| 14 | FC Cincinnati | 34 | 4 | 8 | 22 | 37 | 74 | -37 | 20 | LLLL | 17 | 1 | 5 | 11 | 17 | 29 | 17 | 3 | 3 | 11 | 20 | 45 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | Colorado Rapids | 34 | 17 | 10 | 7 | 51 | 35 | +16 | 61 | WWLW | 17 | 9 | 7 | 1 | 31 | 14 | 17 | 8 | 3 | 6 | 20 | 21 | |
| 2 | Seattle Sounders | 34 | 17 | 9 | 8 | 53 | 33 | +20 | 60 | XXLL | 17 | 8 | 5 | 4 | 28 | 15 | 17 | 9 | 4 | 4 | 25 | 18 | ||
| 3 | 2 | Sporting Kansas City | 34 | 17 | 7 | 10 | 58 | 40 | +18 | 58 | LLLW | 17 | 9 | 5 | 3 | 32 | 17 | 17 | 8 | 2 | 7 | 26 | 23 | |
| 4 | Portland Timbers | 34 | 17 | 4 | 13 | 56 | 52 | +4 | 55 | WWWL | 17 | 11 | 2 | 4 | 35 | 22 | 17 | 6 | 2 | 9 | 21 | 30 | ||
| 5 | 3 | Minnesota United | 34 | 13 | 10 | 11 | 42 | 44 | -2 | 49 | XWLX | 17 | 10 | 3 | 4 | 24 | 14 | 17 | 3 | 7 | 7 | 18 | 30 | |
| 6 | 1 | Vancouver Whitecaps | 34 | 12 | 13 | 9 | 45 | 45 | +0 | 49 | XXWX | 17 | 10 | 3 | 4 | 25 | 17 | 17 | 2 | 10 | 5 | 20 | 28 | |
| 7 | Real Salt Lake | 34 | 14 | 6 | 14 | 55 | 54 | +1 | 48 | WLLW | 17 | 9 | 4 | 4 | 30 | 21 | 17 | 5 | 2 | 10 | 25 | 33 | ||
| 8 | 2 | LA Galaxy | 34 | 13 | 9 | 12 | 50 | 54 | -4 | 48 | XXLX | 17 | 8 | 5 | 4 | 29 | 22 | 17 | 5 | 4 | 8 | 21 | 32 | |
| 9 | Los Angeles | 34 | 12 | 9 | 13 | 53 | 51 | +2 | 45 | LXWX | 17 | 8 | 6 | 3 | 34 | 23 | 17 | 4 | 3 | 10 | 19 | 28 | ||
| 10 | San Jose Earthquakes | 34 | 10 | 11 | 13 | 46 | 54 | -8 | 41 | XWLX | 17 | 5 | 5 | 7 | 25 | 24 | 17 | 5 | 6 | 6 | 21 | 30 | ||
| 11 | 1 | FC Dallas | 34 | 7 | 12 | 15 | 47 | 56 | -9 | 33 | XWLX | 17 | 5 | 7 | 5 | 25 | 21 | 17 | 2 | 5 | 10 | 22 | 35 | |
| 12 | 1 | Austin FC | 34 | 9 | 4 | 21 | 35 | 56 | -21 | 31 | LWLW | 17 | 7 | 2 | 8 | 27 | 25 | 17 | 2 | 2 | 13 | 8 | 31 | |
| 13 | 2 | Houston Dynamo | 34 | 6 | 12 | 16 | 36 | 54 | -18 | 30 | LLLL | 17 | 6 | 6 | 5 | 21 | 22 | 17 | 0 | 6 | 11 | 15 | 32 | |
| Sunday, 7 November 2021 | |||||
| Colorado Rapids | 5-2 | Los Angeles | |||
| Columbus Crew | 2-0 | Chicago Fire | |||
| New England Revolution | 0-1 | Inter Miami | |||
| Sporting Kansas City | 0-1 | Real Salt Lake | |||
| LA Galaxy | 3-3 | Minnesota United | |||
| Vancouver Whitecaps | 1-1 | Seattle Sounders | |||
| CF Montréal | 0-2 | Orlando City | |||
| Portland Timbers | 3-0 | Austin FC | |||
| Toronto FC | 1-3 | D.C. United | |||
| San Jose Earthquakes | 1-1 | FC Dallas | |||
| Nashville | 1-1 | New York Red Bulls | |||
| New York City | 1-1 | Philadelphia Union | |||
| FC Cincinnati | 1-2 | Atlanta United | |||
| 19 | +1 | Valentín CASTELLANOS (New York City, 4p) |
| +2 | Ola KAMARA (D.C. United, 9p) | |
| 17 | Raúl RUIDÍAZ (Seattle Sounders, 4p) | |
| +2 | Javier HERNÁNDEZ (LA Galaxy, 1p) | |
| 16 | +1 | Hany MUKHTAR (Nashville, 1p) |
| Adam BUKSA (New England Revolution) | ||
| Dániel SALLÓI (Sporting Kansas City) | ||
| +1 | Damir KREILACH (Real Salt Lake) | |
| 15 | +1 | Johnny RUSSELL (Sporting Kansas City, 3p) |
| Gustavo BOU (New England Revolution, 1p) | ||
| 14 | +1 | Cristian ARANGO (Los Angeles, 5p) |
| 13 | Ricardo PEPI (FC Dallas) | |
| 12 | Brian WHITE (Vancouver Whitecaps) | |
| +1 | Lucas ZELARAYÁN (Columbus Crew, 1p) | |
| Javier LÓPEZ (San Jose Earthquakes, 1p) | ||
| +1 | Kacper PRZYBYŁKO (Philadelphia Union, 2p) | |
| C.J. SAPONG (Nashville) | ||
| +1 | Josef MARTÍNEZ (Atlanta United, 2p) | |
| Gonzalo HIGUAÍN (Inter Miami, 3p) | ||
| 11 | +1 | Albert RUSNÁK (Real Salt Lake, 3p) |
| Fabrice PICAULT (Houston Dynamo, 3p) | ||
| Felipe MORA (Portland Timbers, 1p) |
