Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 109 | 290 | 2.66 | 54 | 49.54% | 28 | 25.69% | 27 | 24.77% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 8 | 5 | 2 | 1 | 12 | 5 | +7 | 17 | XLWW | 5 | 3 | 2 | 0 | 7 | 2 | 3 | 2 | 0 | 1 | 5 | 3 | ||
| 2 | Orlando City | 8 | 4 | 2 | 2 | 10 | 7 | +3 | 14 | WWLX | 4 | 2 | 0 | 2 | 6 | 6 | 4 | 2 | 2 | 0 | 4 | 1 | ||
| 3 | New York Red Bulls | 7 | 3 | 2 | 2 | 10 | 6 | +4 | 11 | OLWX | 4 | 0 | 2 | 2 | 2 | 4 | 3 | 3 | 0 | 0 | 8 | 2 | ||
| 4 | Atlanta United | 7 | 3 | 2 | 2 | 9 | 9 | +0 | 11 | OLWX | 4 | 2 | 2 | 0 | 8 | 5 | 3 | 1 | 0 | 2 | 1 | 4 | ||
| 5 | Toronto FC | 7 | 3 | 2 | 2 | 11 | 12 | -1 | 11 | WXWW | 4 | 3 | 0 | 1 | 7 | 7 | 3 | 0 | 2 | 1 | 4 | 5 | ||
| 6 | CF Montréal | 8 | 3 | 2 | 3 | 14 | 17 | -3 | 11 | XWWW | 2 | 1 | 0 | 1 | 3 | 3 | 6 | 2 | 2 | 2 | 11 | 14 | ||
| 7 | 1 | Charlotte FC | 9 | 3 | 1 | 5 | 8 | 11 | -3 | 10 | OLWL | 4 | 3 | 0 | 1 | 6 | 2 | 5 | 0 | 1 | 4 | 2 | 9 | |
| 8 | 1 | Chicago Fire | 8 | 2 | 4 | 2 | 5 | 5 | +0 | 10 | LOLO | 4 | 1 | 3 | 0 | 3 | 1 | 4 | 1 | 1 | 2 | 2 | 4 | |
| 9 | 4 | D.C. United | 7 | 3 | 0 | 4 | 10 | 10 | +0 | 9 | WLLL | 5 | 2 | 0 | 3 | 8 | 8 | 2 | 1 | 0 | 1 | 2 | 2 | |
| 10 | 1 | Columbus Crew | 8 | 2 | 3 | 3 | 10 | 9 | +1 | 9 | OLLL | 4 | 2 | 0 | 2 | 6 | 4 | 4 | 0 | 3 | 1 | 4 | 5 | |
| 11 | 3 | New York City | 6 | 2 | 1 | 3 | 11 | 6 | +5 | 7 | WLLW | 3 | 2 | 0 | 1 | 10 | 3 | 3 | 0 | 1 | 2 | 1 | 3 | |
| 12 | 2 | New England Revolution | 8 | 2 | 1 | 5 | 12 | 16 | -4 | 7 | LWLL | 4 | 2 | 0 | 2 | 5 | 5 | 4 | 0 | 1 | 3 | 7 | 11 | |
| 13 | 2 | FC Cincinnati | 7 | 2 | 1 | 4 | 8 | 14 | -6 | 7 | OLLW | 3 | 1 | 0 | 2 | 6 | 6 | 4 | 1 | 1 | 2 | 2 | 8 | |
| 14 | 2 | Inter Miami | 7 | 2 | 1 | 4 | 7 | 15 | -8 | 7 | WWLL | 4 | 1 | 1 | 2 | 4 | 7 | 3 | 1 | 0 | 2 | 3 | 8 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Austin FC | 8 | 5 | 2 | 1 | 20 | 7 | +13 | 17 | WWWX | 5 | 4 | 1 | 0 | 15 | 2 | 3 | 1 | 1 | 1 | 5 | 5 | ||
| 2 | Los Angeles | 7 | 5 | 1 | 1 | 17 | 7 | +10 | 16 | WLWW | 4 | 3 | 1 | 0 | 10 | 3 | 3 | 2 | 0 | 1 | 7 | 4 | ||
| 3 | LA Galaxy | 8 | 5 | 1 | 2 | 10 | 6 | +4 | 16 | WOWW | 4 | 3 | 0 | 1 | 4 | 2 | 4 | 2 | 1 | 1 | 6 | 4 | ||
| 4 | FC Dallas | 8 | 4 | 3 | 1 | 12 | 5 | +7 | 15 | WOWO | 5 | 4 | 1 | 0 | 12 | 4 | 3 | 0 | 2 | 1 | 0 | 1 | ||
| 5 | 2 | Minnesota United | 8 | 4 | 2 | 2 | 11 | 6 | +5 | 14 | WWLL | 5 | 3 | 1 | 1 | 9 | 4 | 3 | 1 | 1 | 1 | 2 | 2 | |
| 6 | Real Salt Lake | 9 | 3 | 4 | 2 | 9 | 13 | -4 | 13 | OLXX | 3 | 2 | 1 | 0 | 5 | 3 | 6 | 1 | 3 | 2 | 4 | 10 | ||
| 7 | 2 | Houston Dynamo | 8 | 3 | 3 | 2 | 11 | 9 | +2 | 12 | LOWW | 5 | 2 | 3 | 0 | 7 | 5 | 3 | 1 | 0 | 2 | 4 | 4 | |
| 8 | Nashville | 8 | 3 | 2 | 3 | 8 | 9 | -1 | 11 | LXWW | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 3 | 8 | 9 | ||
| 9 | Portland Timbers | 9 | 2 | 5 | 2 | 10 | 13 | -3 | 11 | OOWL | 5 | 1 | 3 | 1 | 5 | 6 | 4 | 1 | 2 | 1 | 5 | 7 | ||
| 10 | Colorado Rapids | 8 | 2 | 3 | 3 | 9 | 11 | -2 | 9 | OLLX | 4 | 2 | 2 | 0 | 6 | 1 | 4 | 0 | 1 | 3 | 3 | 10 | ||
| 11 | Seattle Sounders | 7 | 2 | 1 | 4 | 9 | 11 | -2 | 7 | LLWX | 3 | 1 | 0 | 2 | 3 | 4 | 4 | 1 | 1 | 2 | 6 | 7 | ||
| 12 | Sporting Kansas City | 9 | 2 | 1 | 6 | 6 | 14 | -8 | 7 | OLLL | 4 | 2 | 1 | 1 | 3 | 2 | 5 | 0 | 0 | 5 | 3 | 12 | ||
| 13 | 1 | San Jose Earthquakes | 8 | 1 | 3 | 4 | 15 | 20 | -5 | 6 | WXLX | 5 | 1 | 3 | 1 | 12 | 13 | 3 | 0 | 0 | 3 | 3 | 7 | |
| 14 | 1 | Vancouver Whitecaps | 8 | 1 | 1 | 6 | 6 | 17 | -11 | 4 | LLLW | 3 | 1 | 1 | 1 | 3 | 3 | 5 | 0 | 0 | 5 | 3 | 14 | |
| 6 | +1 | Sebastián DRIUSSI (Austin FC, 1p) |
| 5 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Jesús FERREIRA (FC Dallas) | ||
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 4 | +2 | Maximiliano URRUTI (Austin FC) |
| Karol ŚWIDERSKI (Charlotte FC) | ||
| Dániel GAZDAG (Philadelphia Union, 1p) | ||
| +4 | Valentín CASTELLANOS (New York City, 2p) | |
| Djordje MIHAILOVIC (CF Montréal) | ||
| +3 | Cristian ESPINOZA (San Jose Earthquakes, 2p) | |
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Ola KAMARA (D.C. United, 1p) | ||
| Carlos VELA (Los Angeles, 1p) | ||
| Darwin QUINTERO (Houston Dynamo) | ||
| Leonardo CAMPANA (Inter Miami) | ||
| Diego RUBIO (Colorado Rapids) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| 3 | +1 | Julián CARRANZA (Philadelphia Union, 1p) |
| +1 | Michael ESTRADA (D.C. United, 1p) | |
| Lewis MORGAN (New York Red Bulls) | ||
| +1 | Sebastián FERREIRA (Houston Dynamo) | |
| Rommel QUIOTO (CF Montréal, 1p) | ||
| +2 | THIAGO Eduardo ANDRADE (New York City) | |
| +1 | Robin LOD (Minnesota United) | |
| CARLES GIL de Pareja (New England Revolution, 3p) | ||
| Yimmi CHARÁ (Portland Timbers) |
| Sunday, 17 April 2022 | |||||
| Los Angeles | 3-1 | Sporting Kansas City | |||
| 44 | Arango | 38(og) | Palacios | ||
| 70 | Tajouri-Shradi | ||||
| 78 | Cifuentes | ||||
| New York City | 6-0 | Real Salt Lake | |||
| 9 | Castellanos | ||||
| 15 | Thiago Andrade | ||||
| 40(p) | Castellanos | ||||
| 55 | Thiago Andrade | ||||
| 57(p) | Castellanos | ||||
| 80 | Castellanos | ||||
| Saturday, 23 April 2022 | |||||
| D.C. United | 3-2 | New England Revolution | |||
| 26 | Fountas | 6 | Bye | ||
| 39 | Estrada | 86 | Buksa | ||
| 43 | Fountas | ||||
| FC Dallas | 2-1 | Houston Dynamo | |||
| 87 | Ntsabeleng | 33 | Ferreira | ||
| 90 | Quignon | ||||
| Colorado Rapids | 0-0 | Charlotte FC | |||
| Sporting Kansas City | 0-0 | Columbus Crew | |||
| LA Galaxy | 1-0 | Nashville | |||
| 86 | Joveljić | ||||
| Portland Timbers | 0-0 | Real Salt Lake | |||
| San Jose Earthquakes | 4-3 | Seattle Sounders | |||
| 45 | Espinoza | 14(p) | Lodeiro | ||
| 64 | Espinoza | 20 | Roldan | ||
| 65 | Yueill | 57 | Morris | ||
| 90(p) | Espinoza | ||||
| Philadelphia Union | 1-1 | CF Montréal | |||
| 21(p) | Carranza | 59 | Kamara | ||
| Minnesota United | 3-0 | Chicago Fire | |||
| 72 | Reynoso | ||||
| 84 | Arriaga | ||||
| 88 | Lod | ||||
| Austin FC | 3-0 | Vancouver Whitecaps | |||
| 11 | Urruti | ||||
| 26 | Urruti | ||||
| 68 | Driussi | ||||
