Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 233 | 642 | 2.75 | 116 | 49.79% | 57 | 24.46% | 60 | 25.75% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | CF Montréal | 17 | 9 | 2 | 6 | 32 | 29 | +3 | 29 | WWLW | 8 | 5 | 0 | 3 | 16 | 12 | 9 | 4 | 2 | 3 | 16 | 17 | |
| 2 | 2 | Philadelphia Union | 17 | 7 | 8 | 2 | 22 | 13 | +9 | 29 | LWXX | 9 | 4 | 5 | 0 | 11 | 5 | 8 | 3 | 3 | 2 | 11 | 8 | |
| 3 | 2 | New York City | 16 | 8 | 4 | 4 | 31 | 17 | +14 | 28 | XLXW | 9 | 6 | 2 | 1 | 22 | 8 | 7 | 2 | 2 | 3 | 9 | 9 | |
| 4 | 1 | New York Red Bulls | 17 | 7 | 5 | 5 | 26 | 19 | +7 | 26 | LWLW | 8 | 2 | 4 | 2 | 12 | 9 | 9 | 5 | 1 | 3 | 14 | 10 | |
| 5 | Orlando City | 17 | 7 | 4 | 6 | 20 | 23 | -3 | 25 | LWXL | 8 | 4 | 0 | 4 | 11 | 14 | 9 | 3 | 4 | 2 | 9 | 9 | ||
| 6 | FC Cincinnati | 17 | 7 | 3 | 7 | 27 | 30 | -3 | 24 | XWXL | 8 | 3 | 1 | 4 | 16 | 15 | 9 | 4 | 2 | 3 | 11 | 15 | ||
| 7 | New England Revolution | 17 | 6 | 6 | 5 | 27 | 26 | +1 | 24 | OWXW | 9 | 4 | 3 | 2 | 13 | 10 | 8 | 2 | 3 | 3 | 14 | 16 | ||
| 8 | Inter Miami | 16 | 6 | 3 | 7 | 17 | 25 | -8 | 21 | WLWW | 9 | 5 | 2 | 2 | 14 | 12 | 7 | 1 | 1 | 5 | 3 | 13 | ||
| 9 | 3 | Columbus Crew | 16 | 5 | 6 | 5 | 20 | 18 | +2 | 21 | WOXW | 7 | 3 | 1 | 3 | 10 | 7 | 9 | 2 | 5 | 2 | 10 | 11 | |
| 10 | 1 | Charlotte FC | 17 | 6 | 2 | 9 | 17 | 21 | -4 | 20 | LXWL | 8 | 6 | 0 | 2 | 11 | 5 | 9 | 0 | 2 | 7 | 6 | 16 | |
| 11 | 1 | Atlanta United | 15 | 5 | 4 | 6 | 23 | 22 | +1 | 19 | LWLX | 8 | 4 | 3 | 1 | 17 | 10 | 7 | 1 | 1 | 5 | 6 | 12 | |
| 12 | 1 | Toronto FC | 17 | 5 | 3 | 9 | 24 | 32 | -8 | 18 | LWLW | 9 | 5 | 0 | 4 | 14 | 15 | 8 | 0 | 3 | 5 | 10 | 17 | |
| 13 | 1 | Chicago Fire | 17 | 4 | 5 | 8 | 15 | 22 | -7 | 17 | WLWL | 8 | 3 | 3 | 2 | 7 | 5 | 9 | 1 | 2 | 6 | 8 | 17 | |
| 14 | 1 | D.C. United | 15 | 4 | 2 | 9 | 18 | 27 | -9 | 14 | LLLX | 9 | 3 | 1 | 5 | 13 | 15 | 6 | 1 | 1 | 4 | 5 | 12 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 17 | 11 | 3 | 3 | 35 | 18 | +17 | 36 | WWXW | 10 | 7 | 2 | 1 | 23 | 10 | 7 | 4 | 1 | 2 | 12 | 8 | ||
| 2 | Real Salt Lake | 17 | 8 | 5 | 4 | 20 | 19 | +1 | 29 | OWLW | 8 | 6 | 2 | 0 | 13 | 4 | 9 | 2 | 3 | 4 | 7 | 15 | ||
| 3 | Austin FC | 16 | 8 | 4 | 4 | 31 | 20 | +11 | 28 | XWLX | 8 | 4 | 3 | 1 | 19 | 7 | 8 | 4 | 1 | 3 | 12 | 13 | ||
| 4 | FC Dallas | 17 | 7 | 5 | 5 | 27 | 20 | +7 | 26 | LXLW | 8 | 5 | 1 | 2 | 15 | 8 | 9 | 2 | 4 | 3 | 12 | 12 | ||
| 5 | Nashville | 17 | 7 | 5 | 5 | 22 | 19 | +3 | 26 | WLOW | 6 | 2 | 3 | 1 | 8 | 6 | 11 | 5 | 2 | 4 | 14 | 13 | ||
| 6 | LA Galaxy | 16 | 7 | 3 | 6 | 20 | 19 | +1 | 24 | LXWL | 9 | 4 | 1 | 4 | 12 | 13 | 7 | 3 | 2 | 2 | 8 | 6 | ||
| 7 | Seattle Sounders | 16 | 7 | 2 | 7 | 24 | 19 | +5 | 23 | LWXW | 9 | 5 | 1 | 3 | 17 | 9 | 7 | 2 | 1 | 4 | 7 | 10 | ||
| 8 | 3 | Portland Timbers | 18 | 5 | 7 | 6 | 27 | 27 | +0 | 22 | WWXL | 9 | 4 | 3 | 2 | 17 | 11 | 9 | 1 | 4 | 4 | 10 | 16 | |
| 9 | 1 | Houston Dynamo | 17 | 6 | 3 | 8 | 21 | 21 | +0 | 21 | LWLL | 9 | 4 | 3 | 2 | 12 | 8 | 8 | 2 | 0 | 6 | 9 | 13 | |
| 10 | 2 | Minnesota United | 17 | 6 | 3 | 8 | 20 | 21 | -1 | 21 | WLLL | 8 | 3 | 2 | 3 | 10 | 7 | 9 | 3 | 1 | 5 | 10 | 14 | |
| 11 | 2 | Vancouver Whitecaps | 17 | 6 | 3 | 8 | 18 | 28 | -10 | 21 | OWLW | 8 | 4 | 3 | 1 | 11 | 8 | 9 | 2 | 0 | 7 | 7 | 20 | |
| 12 | 2 | Colorado Rapids | 16 | 5 | 4 | 7 | 17 | 21 | -4 | 19 | LXLW | 8 | 5 | 2 | 1 | 12 | 4 | 8 | 0 | 2 | 6 | 5 | 17 | |
| 13 | Sporting Kansas City | 18 | 4 | 4 | 10 | 16 | 32 | -16 | 16 | LWLL | 8 | 3 | 2 | 3 | 8 | 8 | 10 | 1 | 2 | 7 | 8 | 24 | ||
| 14 | San Jose Earthquakes | 16 | 3 | 6 | 7 | 25 | 34 | -9 | 15 | LOLX | 8 | 3 | 4 | 1 | 17 | 16 | 8 | 0 | 2 | 6 | 8 | 18 | ||
| 10 | +1 | Jesús FERREIRA (FC Dallas) |
| 9 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| Sebastián DRIUSSI (Austin FC, 2p) | ||
| 8 | +1 | Valentín CASTELLANOS (New York City, 4p) |
| Hany MUKHTAR (Nashville) | ||
| Paul ARRIOLA (FC Dallas) | ||
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| +1 | Jesús JIMÉNEZ (Toronto FC) | |
| 7 | Lewis MORGAN (New York Red Bulls, 2p) | |
| Dániel GAZDAG (Philadelphia Union, 1p) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| Adam BUKSA (New England Revolution) | ||
| +1 | Darwin QUINTERO (Houston Dynamo, 1p) | |
| Leonardo CAMPANA (Inter Miami) | ||
| Diego RUBIO (Colorado Rapids, 1p) | ||
| 6 | +2 | Cristian ARANGO (Los Angeles, 1p) |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Sebastián FERREIRA (Houston Dynamo) | ||
| Ercan KARA (Orlando City) | ||
| Ola KAMARA (D.C. United, 1p) | ||
| Carlos VELA (Los Angeles, 2p) | ||
| Rommel QUIOTO (CF Montréal, 2p) | ||
| Taxiarchis FOUNTAS (D.C. United) | ||
| +1 | Luciano ACOSTA (FC Cincinnati, 2p) | |
| Robin LOD (Minnesota United) |
| Sunday, 26 June 2022 | |||||
| Vancouver Whitecaps | 0-0 | New England Revolution | |||
| Philadelphia Union | 2-1 | New York City | |||
| 9 | Uhre | 89(p) | Castellanos | ||
| 90 | Burke | ||||
| Los Angeles | 2-0 | New York Red Bulls | |||
| 67 | Arango | ||||
| 70 | Palacios | ||||
| Wednesday, 29 June 2022 | |||||
| LA Galaxy | 2-3 | Minnesota United | |||
| 60(p) | Delgado | 9 | Reynoso | ||
| 90 | Joveljić | 36 | Fragapane | ||
| 43 | Reynoso | ||||
| Chicago Fire | 1-0 | Philadelphia Union | |||
| 68 | Navarro | ||||
| Portland Timbers | 2-1 | Houston Dynamo | |||
| 34(p) | Moreno | 65 | Quintero | ||
| 36 | Moreno | ||||
| Seattle Sounders | 1-2 | CF Montréal | |||
| 3 | Morris | 18 | Toye | ||
| 62 | Toye | ||||
| Toronto FC | 1-2 | Columbus Crew | |||
| 54 | Jiménez | 18 | Zawadzki | ||
| 30 | Nagbe | ||||
| Los Angeles | 3-1 | FC Dallas | |||
| 23 | Musovski | 38 | Ferreira | ||
| 57 | Arango | ||||
| 86 | Opoku | ||||
| FC Cincinnati | 4-4 | New York City | |||
| 15 | Acosta | 45 | Talles Magno | ||
| 24 | Brenner | 45 | Héber | ||
| 30 | Brenner | 45 | Héber | ||
| 70 | Brenner | 52 | Gabriel Pereira | ||
