Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 223 | 610 | 2.73 | 111 | 49.78% | 55 | 24.66% | 57 | 25.56% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York City | 14 | 8 | 3 | 3 | 26 | 11 | +15 | 27 | XWWW | 9 | 6 | 2 | 1 | 22 | 8 | 5 | 2 | 1 | 2 | 4 | 3 | ||
| 2 | 3 | CF Montréal | 16 | 8 | 2 | 6 | 30 | 28 | +2 | 26 | WLWL | 8 | 5 | 0 | 3 | 16 | 12 | 8 | 3 | 2 | 3 | 14 | 16 | |
| 3 | 1 | New York Red Bulls | 16 | 7 | 5 | 4 | 26 | 17 | +9 | 26 | WLWL | 8 | 2 | 4 | 2 | 12 | 9 | 8 | 5 | 1 | 2 | 14 | 8 | |
| 4 | 1 | Philadelphia Union | 15 | 6 | 8 | 1 | 20 | 11 | +9 | 26 | XXWO | 8 | 3 | 5 | 0 | 9 | 4 | 7 | 3 | 3 | 1 | 11 | 7 | |
| 5 | 1 | Orlando City | 17 | 7 | 4 | 6 | 20 | 23 | -3 | 25 | LWXL | 8 | 4 | 0 | 4 | 11 | 14 | 9 | 3 | 4 | 2 | 9 | 9 | |
| 6 | 1 | FC Cincinnati | 16 | 7 | 2 | 7 | 23 | 26 | -3 | 23 | WXLL | 7 | 3 | 0 | 4 | 12 | 11 | 9 | 4 | 2 | 3 | 11 | 15 | |
| 7 | 1 | New England Revolution | 16 | 6 | 5 | 5 | 27 | 26 | +1 | 23 | WXWX | 9 | 4 | 3 | 2 | 13 | 10 | 7 | 2 | 2 | 3 | 14 | 16 | |
| 8 | 1 | Inter Miami | 16 | 6 | 3 | 7 | 17 | 25 | -8 | 21 | WLWW | 9 | 5 | 2 | 2 | 14 | 12 | 7 | 1 | 1 | 5 | 3 | 13 | |
| 9 | 3 | Charlotte FC | 17 | 6 | 2 | 9 | 17 | 21 | -4 | 20 | LXWL | 8 | 6 | 0 | 2 | 11 | 5 | 9 | 0 | 2 | 7 | 6 | 16 | |
| 10 | 1 | Atlanta United | 15 | 5 | 4 | 6 | 23 | 22 | +1 | 19 | LWLX | 8 | 4 | 3 | 1 | 17 | 10 | 7 | 1 | 1 | 5 | 6 | 12 | |
| 11 | 1 | Toronto FC | 16 | 5 | 3 | 8 | 23 | 30 | -7 | 18 | WLWX | 8 | 5 | 0 | 3 | 13 | 13 | 8 | 0 | 3 | 5 | 10 | 17 | |
| 12 | 2 | Columbus Crew | 15 | 4 | 6 | 5 | 18 | 17 | +1 | 18 | OXWL | 7 | 3 | 1 | 3 | 10 | 7 | 8 | 1 | 5 | 2 | 8 | 10 | |
| 13 | D.C. United | 15 | 4 | 2 | 9 | 18 | 27 | -9 | 14 | LLLX | 9 | 3 | 1 | 5 | 13 | 15 | 6 | 1 | 1 | 4 | 5 | 12 | ||
| 14 | Chicago Fire | 16 | 3 | 5 | 8 | 14 | 22 | -8 | 14 | LWLL | 7 | 2 | 3 | 2 | 6 | 5 | 9 | 1 | 2 | 6 | 8 | 17 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 15 | 9 | 3 | 3 | 30 | 17 | +13 | 30 | XWWL | 8 | 5 | 2 | 1 | 18 | 9 | 7 | 4 | 1 | 2 | 12 | 8 | ||
| 2 | Real Salt Lake | 17 | 8 | 5 | 4 | 20 | 19 | +1 | 29 | OWLW | 8 | 6 | 2 | 0 | 13 | 4 | 9 | 2 | 3 | 4 | 7 | 15 | ||
| 3 | Austin FC | 16 | 8 | 4 | 4 | 31 | 20 | +11 | 28 | XWLX | 8 | 4 | 3 | 1 | 19 | 7 | 8 | 4 | 1 | 3 | 12 | 13 | ||
| 4 | FC Dallas | 16 | 7 | 5 | 4 | 26 | 17 | +9 | 26 | XLWL | 8 | 5 | 1 | 2 | 15 | 8 | 8 | 2 | 4 | 2 | 11 | 9 | ||
| 5 | 1 | Nashville | 17 | 7 | 5 | 5 | 22 | 19 | +3 | 26 | WLOW | 6 | 2 | 3 | 1 | 8 | 6 | 11 | 5 | 2 | 4 | 14 | 13 | |
| 6 | 1 | LA Galaxy | 15 | 7 | 3 | 5 | 18 | 16 | +2 | 24 | XWLX | 8 | 4 | 1 | 3 | 10 | 10 | 7 | 3 | 2 | 2 | 8 | 6 | |
| 7 | Seattle Sounders | 15 | 7 | 2 | 6 | 23 | 17 | +6 | 23 | WXWW | 8 | 5 | 1 | 2 | 16 | 7 | 7 | 2 | 1 | 4 | 7 | 10 | ||
| 8 | 2 | Houston Dynamo | 16 | 6 | 3 | 7 | 20 | 19 | +1 | 21 | WLLW | 9 | 4 | 3 | 2 | 12 | 8 | 7 | 2 | 0 | 5 | 8 | 11 | |
| 9 | 1 | Vancouver Whitecaps | 16 | 6 | 2 | 8 | 18 | 28 | -10 | 20 | WLWW | 7 | 4 | 2 | 1 | 11 | 8 | 9 | 2 | 0 | 7 | 7 | 20 | |
| 10 | 1 | Colorado Rapids | 16 | 5 | 4 | 7 | 17 | 21 | -4 | 19 | LXLW | 8 | 5 | 2 | 1 | 12 | 4 | 8 | 0 | 2 | 6 | 5 | 17 | |
| 11 | 1 | Portland Timbers | 17 | 4 | 7 | 6 | 25 | 26 | -1 | 19 | WXLL | 8 | 3 | 3 | 2 | 15 | 10 | 9 | 1 | 4 | 4 | 10 | 16 | |
| 12 | 3 | Minnesota United | 16 | 5 | 3 | 8 | 17 | 19 | -2 | 18 | LLLW | 8 | 3 | 2 | 3 | 10 | 7 | 8 | 2 | 1 | 5 | 7 | 12 | |
| 13 | 1 | Sporting Kansas City | 18 | 4 | 4 | 10 | 16 | 32 | -16 | 16 | LWLL | 8 | 3 | 2 | 3 | 8 | 8 | 10 | 1 | 2 | 7 | 8 | 24 | |
| 14 | 1 | San Jose Earthquakes | 16 | 3 | 6 | 7 | 25 | 34 | -9 | 15 | LOLX | 8 | 3 | 4 | 1 | 17 | 16 | 8 | 0 | 2 | 6 | 8 | 18 | |
| 9 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| Jesús FERREIRA (FC Dallas) | ||
| +1 | Sebastián DRIUSSI (Austin FC, 2p) | |
| 8 | +2 | Hany MUKHTAR (Nashville) |
| +1 | Paul ARRIOLA (FC Dallas) | |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 7 | Lewis MORGAN (New York Red Bulls, 2p) | |
| Dániel GAZDAG (Philadelphia Union, 1p) | ||
| Valentín CASTELLANOS (New York City, 3p) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| Adam BUKSA (New England Revolution) | ||
| Leonardo CAMPANA (Inter Miami) | ||
| Diego RUBIO (Colorado Rapids, 1p) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| 6 | Javier HERNÁNDEZ (LA Galaxy) | |
| Sebastián FERREIRA (Houston Dynamo) | ||
| Ercan KARA (Orlando City) | ||
| Ola KAMARA (D.C. United, 1p) | ||
| Carlos VELA (Los Angeles, 2p) | ||
| +1 | Rommel QUIOTO (CF Montréal, 2p) | |
| +1 | Darwin QUINTERO (Houston Dynamo, 1p) | |
| +1 | Taxiarchis FOUNTAS (D.C. United) | |
| Robin LOD (Minnesota United) |
| Sunday, 19 June 2022 | |||||
| New England Revolution | 2-1 | Minnesota United | |||
| 53 | Borrero | 37(p) | Reynoso | ||
| 69 | Bou | ||||
| Nashville | 1-2 | Sporting Kansas City | |||
| 63 | Loba | 41 | Hernández | ||
| 51 | Zusi | ||||
| New York City | 1-1 | Colorado Rapids | |||
| 72 | Talles Magno | 68 | Barrios | ||
| Atlanta United | 2-0 | Inter Miami | |||
| 4 | Luiz Araújo | ||||
| 61 | Martínez | ||||
| Friday, 24 June 2022 | |||||
| FC Cincinnati | 1-0 | Orlando City | |||
| 65 | Brenner | ||||
| Saturday, 25 June 2022 | |||||
| D.C. United | 1-3 | Nashville | |||
| 59 | Fountas | 6 | Lovitz | ||
| 45 | Mukhtar | ||||
| 50 | Mukhtar | ||||
| Houston Dynamo | 2-0 | Chicago Fire | |||
| 23 | Úlfarsson | ||||
| 45 | Quintero | ||||
| CF Montréal | 2-1 | Charlotte FC | |||
| 6 | Quioto | 9 | Corujo | ||
| 47 | Choinière | ||||
| Portland Timbers | 3-0 | Colorado Rapids | |||
| 45(p) | Blanco | ||||
| 54 | Niezgoda | ||||
| 62 | Niezgoda | ||||
| Seattle Sounders | 3-0 | Sporting Kansas City | |||
| 8 | Bruin | ||||
| 71 | Morris | ||||
| 76 | Roldan | ||||
| Real Salt Lake | 0-0 | Columbus Crew | |||
| Toronto FC | 2-1 | Atlanta United | |||
| 8 | Osorio | 57 | Luiz Araújo | ||
| 78 | Priso-Mbongue | ||||
| Austin FC | 2-2 | FC Dallas | |||
| 72 | Driussi | 58 | Arriola | ||
| 85 | Hoesen | 68 | Servania | ||
| Inter Miami | 2-1 | Minnesota United | |||
| 87 | Vassilev | 65 | Amarilla | ||
| 90 | Vassilev | ||||
