Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 316 | 895 | 2.83 | 148 | 46.84% | 82 | 25.95% | 86 | 27.22% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 23 | 12 | 9 | 2 | 40 | 15 | +25 | 45 | WWWW | 12 | 7 | 5 | 0 | 26 | 6 | 11 | 5 | 4 | 2 | 14 | 9 | ||
| 2 | New York City | 22 | 12 | 6 | 4 | 41 | 21 | +20 | 42 | OWWW | 12 | 8 | 3 | 1 | 30 | 12 | 10 | 4 | 3 | 3 | 11 | 9 | ||
| 3 | 1 | CF Montréal | 22 | 11 | 3 | 8 | 36 | 36 | +0 | 36 | OWWL | 11 | 6 | 1 | 4 | 18 | 14 | 11 | 5 | 2 | 4 | 18 | 22 | |
| 4 | 1 | New York Red Bulls | 23 | 10 | 6 | 7 | 38 | 30 | +8 | 36 | LWLX | 11 | 3 | 4 | 4 | 18 | 16 | 12 | 7 | 2 | 3 | 20 | 14 | |
| 5 | Orlando City | 23 | 8 | 6 | 9 | 27 | 33 | -6 | 30 | LLXX | 11 | 5 | 0 | 6 | 15 | 20 | 12 | 3 | 6 | 3 | 12 | 13 | ||
| 6 | Columbus Crew | 21 | 7 | 9 | 5 | 27 | 22 | +5 | 30 | OWXW | 10 | 4 | 3 | 3 | 12 | 7 | 11 | 3 | 6 | 2 | 15 | 15 | ||
| 7 | FC Cincinnati | 23 | 7 | 8 | 8 | 37 | 42 | -5 | 29 | XXLX | 11 | 3 | 4 | 4 | 20 | 19 | 12 | 4 | 4 | 4 | 17 | 23 | ||
| 8 | 1 | Chicago Fire | 23 | 7 | 6 | 10 | 24 | 28 | -4 | 27 | OWWW | 12 | 5 | 4 | 3 | 12 | 8 | 11 | 2 | 2 | 7 | 12 | 20 | |
| 9 | 1 | New England Revolution | 22 | 6 | 9 | 7 | 32 | 34 | -2 | 27 | OOLL | 11 | 4 | 5 | 2 | 15 | 12 | 11 | 2 | 4 | 5 | 17 | 22 | |
| 10 | 2 | Charlotte FC | 22 | 8 | 2 | 12 | 25 | 31 | -6 | 26 | LLWW | 10 | 7 | 0 | 3 | 15 | 7 | 12 | 1 | 2 | 9 | 10 | 24 | |
| 11 | Inter Miami | 22 | 7 | 5 | 10 | 26 | 37 | -11 | 26 | XLWL | 12 | 6 | 3 | 3 | 22 | 20 | 10 | 1 | 2 | 7 | 4 | 17 | ||
| 12 | Atlanta United | 22 | 6 | 7 | 9 | 29 | 33 | -4 | 25 | OLXW | 11 | 5 | 4 | 2 | 20 | 15 | 11 | 1 | 3 | 7 | 9 | 18 | ||
| 13 | Toronto FC | 23 | 6 | 5 | 12 | 30 | 39 | -9 | 23 | OWLL | 12 | 6 | 1 | 5 | 20 | 19 | 11 | 0 | 4 | 7 | 10 | 20 | ||
| 14 | D.C. United | 21 | 6 | 3 | 12 | 28 | 44 | -16 | 21 | WLLX | 12 | 4 | 2 | 6 | 18 | 20 | 9 | 2 | 1 | 6 | 10 | 24 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 22 | 15 | 3 | 4 | 44 | 23 | +21 | 48 | WWWW | 12 | 9 | 2 | 1 | 28 | 13 | 10 | 6 | 1 | 3 | 16 | 10 | ||
| 2 | Austin FC | 23 | 13 | 5 | 5 | 47 | 28 | +19 | 44 | WLXW | 10 | 5 | 3 | 2 | 25 | 12 | 13 | 8 | 2 | 3 | 22 | 16 | ||
| 3 | Minnesota United | 23 | 10 | 5 | 8 | 35 | 30 | +5 | 35 | XWWX | 12 | 5 | 4 | 3 | 20 | 14 | 11 | 5 | 1 | 5 | 15 | 16 | ||
| 4 | 1 | FC Dallas | 24 | 9 | 8 | 7 | 33 | 26 | +7 | 35 | LWWX | 12 | 6 | 3 | 3 | 18 | 11 | 12 | 3 | 5 | 4 | 15 | 15 | |
| 5 | 1 | Real Salt Lake | 23 | 9 | 7 | 7 | 30 | 29 | +1 | 34 | XLWL | 11 | 7 | 3 | 1 | 18 | 7 | 12 | 2 | 4 | 6 | 12 | 22 | |
| 6 | 3 | Seattle Sounders | 23 | 10 | 2 | 11 | 30 | 27 | +3 | 32 | WLWL | 12 | 7 | 1 | 4 | 20 | 13 | 11 | 3 | 1 | 7 | 10 | 14 | |
| 7 | 1 | Nashville | 23 | 8 | 8 | 7 | 29 | 29 | +0 | 32 | XXLW | 10 | 3 | 5 | 2 | 13 | 11 | 13 | 5 | 3 | 5 | 16 | 18 | |
| 8 | Portland Timbers | 23 | 7 | 10 | 6 | 39 | 35 | +4 | 31 | XWXW | 11 | 5 | 4 | 2 | 20 | 13 | 12 | 2 | 6 | 4 | 19 | 22 | ||
| 9 | 2 | LA Galaxy | 22 | 9 | 3 | 10 | 30 | 28 | +2 | 30 | LWLL | 12 | 6 | 1 | 5 | 20 | 16 | 10 | 3 | 2 | 5 | 10 | 12 | |
| 10 | 2 | Colorado Rapids | 22 | 7 | 6 | 9 | 30 | 33 | -3 | 27 | WLWX | 11 | 6 | 3 | 2 | 17 | 8 | 11 | 1 | 3 | 7 | 13 | 25 | |
| 11 | 1 | Vancouver Whitecaps | 23 | 7 | 6 | 10 | 25 | 38 | -13 | 27 | XLXX | 11 | 5 | 3 | 3 | 14 | 14 | 12 | 2 | 3 | 7 | 11 | 24 | |
| 12 | 1 | Houston Dynamo | 23 | 7 | 4 | 12 | 28 | 37 | -9 | 25 | LLWL | 12 | 4 | 4 | 4 | 16 | 14 | 11 | 3 | 0 | 8 | 12 | 23 | |
| 13 | San Jose Earthquakes | 22 | 5 | 8 | 9 | 36 | 45 | -9 | 23 | XLLW | 11 | 4 | 5 | 2 | 22 | 21 | 11 | 1 | 3 | 7 | 14 | 24 | ||
| 14 | Sporting Kansas City | 24 | 5 | 5 | 14 | 19 | 42 | -23 | 20 | LLLX | 11 | 3 | 2 | 6 | 8 | 13 | 13 | 2 | 3 | 8 | 11 | 29 | ||
| 14 | +1 | Sebastián DRIUSSI (Austin FC, 2p) |
| 13 | Valentín CASTELLANOS (New York City, 5p) | |
| +2 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 12 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| Hany MUKHTAR (Nashville, 2p) | ||
| Jesús FERREIRA (FC Dallas) | ||
| 11 | +1 | Dániel GAZDAG (Philadelphia Union, 3p) |
| +1 | Taxiarchis FOUNTAS (D.C. United) | |
| 10 | +1 | Lewis MORGAN (New York Red Bulls, 5p) |
| +1 | Diego RUBIO (Colorado Rapids, 2p) | |
| 9 | +1 | Jarosław NIEZGODA (Portland Timbers) |
| Dejan JOVELJIĆ (LA Galaxy, 1p) | ||
| Cristian ARANGO (Los Angeles, 1p) | ||
| Paul ARRIOLA (FC Dallas) | ||
| Rommel QUIOTO (CF Montréal, 2p) | ||
| Emanuel REYNOSO (Minnesota United, 2p) | ||
| 8 | +1 | Julián CARRANZA (Philadelphia Union, 1p) |
| Leonardo CAMPANA (Inter Miami) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| +2 | Mikael UHRE (Philadelphia Union) |
| Friday, 29 July 2022 | |||||
| Los Angeles | 2-1 | Seattle Sounders | |||
| 35 | Opoku | 14(og) | Murillo | ||
| 43 | Vela | ||||
| Saturday, 30 July 2022 | |||||
| FC Dallas | 1-0 | LA Galaxy | |||
| 9 | Jara | ||||
| New England Revolution | 0-0 | Toronto FC | |||
| Sporting Kansas City | 0-2 | Austin FC | |||
| 45 | Ring | ||||
| 90 | Driussi | ||||
| Chicago Fire | 0-0 | Atlanta United | |||
| CF Montréal | 0-0 | New York City | |||
| San Jose Earthquakes | 2-2 | Real Salt Lake | |||
| 12(p) | Espinoza | 21 | Löffelsend | ||
| 62 | Ebobisse | 90 | Savarino | ||
| Philadelphia Union | 6-0 | Houston Dynamo | |||
| 23 | Gazdag | ||||
| 42 | McGlynn | ||||
| 45 | Uhre | ||||
| 48 | Uhre | ||||
| 55 | Carranza | ||||
| 89 | Sullivan | ||||
| Minnesota United | 4-4 | Portland Timbers | |||
| 9 | Fragapane | 1 | Blanco | ||
| 21 | Hlongwane | 50 | Blanco | ||
| 41 | Amarilla | 53 | Niezgoda | ||
| 69 | Amarilla | 65(og) | Lawrence | ||
| Nashville | 1-1 | Vancouver Whitecaps | |||
| 17 | Bunbury | 87 | Brown | ||
| Inter Miami | 4-4 | FC Cincinnati | |||
| 23 | Higuaín | 28 | Brenner | ||
| 37 | Higuaín | 40 | Brenner | ||
| 45(p) | Higuaín | 81 | Vázquez | ||
| 90 | McVey | 86 | Vázquez | ||
| Charlotte FC | A-A | Columbus Crew | |||
| Abandoned at 0-0 after 16 minutes. To be completed. | |||||
| Sunday, 31 July 2022 | |||||
| D.C. United | 2-1 | Orlando City | |||
| 90 | Durkin | 9 | Júnior Urso | ||
| 90 | Fountas | ||||
| Tuesday, 2 August 2022 | |||||
| New York Red Bulls | 4-5 | Colorado Rapids | |||
| 6 | Yearwood | 21 | Rubio | ||
| 9 | Long | 38 | Rosenberry | ||
| 28(p) | Morgan | 77 | Warner | ||
| 90(p) | Barlow | 80 | Barrios | ||
| 89 | Touré | ||||
| Seattle Sounders | 1-0 | FC Dallas | |||
| 39(p) | Lodeiro | ||||
