Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 421 | 1,244 | 2.95 | 203 | 48.22% | 107 | 25.42% | 111 | 26.37% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 31 | 18 | 9 | 4 | 68 | 22 | +46 | 63 | WWWW | 16 | 11 | 5 | 0 | 45 | 9 | 15 | 7 | 4 | 4 | 23 | 13 | ||
| 2 | CF Montréal | 30 | 16 | 5 | 9 | 55 | 47 | +8 | 53 | XWLW | 15 | 7 | 3 | 5 | 26 | 19 | 15 | 9 | 2 | 4 | 29 | 28 | ||
| 3 | New York Red Bulls | 31 | 14 | 8 | 9 | 47 | 37 | +10 | 50 | WLWW | 16 | 5 | 5 | 6 | 24 | 22 | 15 | 9 | 3 | 3 | 23 | 15 | ||
| 4 | New York City | 31 | 13 | 7 | 11 | 51 | 39 | +12 | 46 | LXLL | 15 | 8 | 4 | 3 | 33 | 18 | 16 | 5 | 3 | 8 | 18 | 21 | ||
| 5 | Orlando City | 29 | 12 | 6 | 11 | 36 | 45 | -9 | 42 | LWWW | 14 | 7 | 0 | 7 | 20 | 26 | 15 | 5 | 6 | 4 | 16 | 19 | ||
| 6 | 2 | FC Cincinnati | 30 | 10 | 12 | 8 | 54 | 49 | +5 | 42 | WXWX | 16 | 6 | 6 | 4 | 35 | 24 | 14 | 4 | 6 | 4 | 19 | 25 | |
| 7 | 1 | Columbus Crew | 29 | 9 | 14 | 6 | 39 | 33 | +6 | 41 | XOWX | 15 | 6 | 5 | 4 | 19 | 13 | 14 | 3 | 9 | 2 | 20 | 20 | |
| 8 | 1 | New England Revolution | 30 | 9 | 11 | 10 | 43 | 44 | -1 | 38 | LWOL | 15 | 6 | 6 | 3 | 20 | 14 | 15 | 3 | 5 | 7 | 23 | 30 | |
| 9 | Inter Miami | 29 | 10 | 6 | 13 | 36 | 49 | -13 | 36 | LLLW | 14 | 8 | 3 | 3 | 27 | 23 | 15 | 2 | 3 | 10 | 9 | 26 | ||
| 10 | 1 | Atlanta United | 30 | 9 | 9 | 12 | 45 | 50 | -5 | 36 | WLLW | 15 | 8 | 4 | 3 | 30 | 22 | 15 | 1 | 5 | 9 | 15 | 28 | |
| 11 | 1 | Charlotte FC | 30 | 11 | 2 | 17 | 35 | 46 | -11 | 35 | WLLL | 15 | 9 | 0 | 6 | 22 | 14 | 15 | 2 | 2 | 11 | 13 | 32 | |
| 12 | 1 | Chicago Fire | 30 | 9 | 8 | 13 | 31 | 39 | -8 | 35 | WOOL | 15 | 6 | 4 | 5 | 15 | 13 | 15 | 3 | 4 | 8 | 16 | 26 | |
| 13 | 3 | Toronto FC | 31 | 9 | 7 | 15 | 49 | 57 | -8 | 34 | LLXW | 16 | 7 | 3 | 6 | 30 | 28 | 15 | 2 | 4 | 9 | 19 | 29 | |
| 14 | D.C. United | 30 | 7 | 6 | 17 | 32 | 59 | -27 | 27 | OOWL | 15 | 4 | 4 | 7 | 18 | 26 | 15 | 3 | 2 | 10 | 14 | 33 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 30 | 19 | 3 | 8 | 60 | 34 | +26 | 60 | LWLL | 15 | 12 | 2 | 1 | 36 | 13 | 15 | 7 | 1 | 7 | 24 | 21 | ||
| 2 | Austin FC | 30 | 15 | 6 | 9 | 60 | 45 | +15 | 51 | LLLW | 14 | 7 | 4 | 3 | 37 | 21 | 16 | 8 | 2 | 6 | 23 | 24 | ||
| 3 | FC Dallas | 31 | 13 | 10 | 8 | 45 | 34 | +11 | 49 | WWXL | 16 | 9 | 4 | 3 | 26 | 14 | 15 | 4 | 6 | 5 | 19 | 20 | ||
| 4 | Nashville | 31 | 12 | 10 | 9 | 49 | 38 | +11 | 46 | XWWW | 16 | 6 | 6 | 4 | 29 | 19 | 15 | 6 | 4 | 5 | 20 | 19 | ||
| 5 | 2 | Portland Timbers | 31 | 11 | 12 | 8 | 50 | 47 | +3 | 45 | WWWW | 16 | 8 | 6 | 2 | 27 | 17 | 15 | 3 | 6 | 6 | 23 | 30 | |
| 6 | 1 | Minnesota United | 30 | 13 | 5 | 12 | 44 | 44 | +0 | 44 | LLLW | 15 | 7 | 4 | 4 | 24 | 19 | 15 | 6 | 1 | 8 | 20 | 25 | |
| 7 | 1 | Real Salt Lake | 30 | 11 | 10 | 9 | 38 | 38 | +0 | 43 | OLWX | 15 | 8 | 5 | 2 | 23 | 12 | 15 | 3 | 5 | 7 | 15 | 26 | |
| 8 | LA Galaxy | 29 | 11 | 7 | 11 | 47 | 43 | +4 | 40 | XXXW | 15 | 7 | 3 | 5 | 30 | 23 | 14 | 4 | 4 | 6 | 17 | 20 | ||
| 9 | Seattle Sounders | 30 | 12 | 3 | 15 | 43 | 40 | +3 | 39 | WWLL | 15 | 9 | 1 | 5 | 26 | 16 | 15 | 3 | 2 | 10 | 17 | 24 | ||
| 10 | 1 | Colorado Rapids | 30 | 9 | 9 | 12 | 41 | 51 | -10 | 36 | WOLL | 15 | 8 | 5 | 2 | 26 | 14 | 15 | 1 | 4 | 10 | 15 | 37 | |
| 11 | 1 | Vancouver Whitecaps | 30 | 9 | 7 | 14 | 33 | 54 | -21 | 34 | LLLX | 14 | 7 | 3 | 4 | 18 | 19 | 16 | 2 | 4 | 10 | 15 | 35 | |
| 12 | Sporting Kansas City | 30 | 8 | 7 | 15 | 33 | 51 | -18 | 31 | OXWW | 14 | 6 | 2 | 6 | 17 | 16 | 16 | 2 | 5 | 9 | 16 | 35 | ||
| 13 | 1 | Houston Dynamo | 30 | 8 | 6 | 16 | 36 | 48 | -12 | 30 | OLWL | 15 | 5 | 5 | 5 | 20 | 18 | 15 | 3 | 1 | 11 | 16 | 30 | |
| 14 | 1 | San Jose Earthquakes | 29 | 7 | 9 | 13 | 44 | 61 | -17 | 30 | LWLW | 14 | 6 | 5 | 3 | 26 | 23 | 15 | 1 | 4 | 10 | 18 | 38 | |
| 22 | +1 | Hany MUKHTAR (Nashville, 5p) |
| 20 | Sebastián DRIUSSI (Austin FC, 3p) | |
| 19 | +1 | Dániel GAZDAG (Philadelphia Union, 6p) |
| 18 | +2 | Jesús FERREIRA (FC Dallas) |
| 16 | +1 | Cristian ARANGO (Los Angeles, 1p) |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 15 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| Rommel QUIOTO (CF Montréal, 4p) | ||
| 14 | Julián CARRANZA (Philadelphia Union, 2p) | |
| +1 | Lewis MORGAN (New York Red Bulls, 6p) | |
| Javier HERNÁNDEZ (LA Galaxy, 3p) | ||
| 13 | Valentín CASTELLANOS (New York City, 5p) | |
| +1 | Diego RUBIO (Colorado Rapids, 4p) | |
| 12 | +3 | BRENNER Souza (FC Cincinnati, 1p) |
| +1 | Mikael UHRE (Philadelphia Union) | |
| 11 | Taxiarchis FOUNTAS (D.C. United) | |
| 10 | Dejan JOVELJIĆ (LA Galaxy, 2p) | |
| Sebastián FERREIRA (Houston Dynamo, 1p) | ||
| +1 | Gyasi ZARDES (Colorado Rapids, 1p) | |
| Emanuel REYNOSO (Minnesota United, 3p) | ||
| +1 | Gonzalo HIGUAÍN (Inter Miami, 4p) |
| Wednesday, 7 September 2022 | |||||
| New York City | 1-1 | FC Cincinnati | |||
| 41 | Gabriel Pereira | 22(og) | Thiago Martins | ||
| Friday, 9 September 2022 | |||||
| CF Montréal | 2-2 | Columbus Crew | |||
| 89 | Wanyama | 66 | Mensah | ||
| 90 | Brault-Guillard | 68 | Zelarayán | ||
| Saturday, 10 September 2022 | |||||
| FC Dallas | 2-1 | Los Angeles | |||
| 78 | Ferreira | 45 | Arango | ||
| 81 | Ferreira | ||||
| Houston Dynamo | 0-0 | Sporting Kansas City | |||
| Colorado Rapids | 3-1 | Vancouver Whitecaps | |||
| 21 | Zardes | 9 | White | ||
| 33(p) | Rubio | ||||
| 75 | Lewis | ||||
| New York Red Bulls | 2-1 | New England Revolution | |||
| 58 | Cásseres | 53 | McNamara | ||
| 78(p) | Morgan | ||||
| Chicago Fire | 3-1 | Inter Miami | |||
| 40 | Durán | 77(p) | Higuaín | ||
| 64 | Shaqiri | ||||
| 87 | Durán | ||||
| Portland Timbers | 1-0 | Minnesota United | |||
| 61 | Asprilla | ||||
| Seattle Sounders | 3-0 | Austin FC | |||
| 12 | Ruidíaz | ||||
| 34 | Ruidíaz | ||||
| 68(og) | Gabrielsen | ||||
| Real Salt Lake | 0-0 | D.C. United | |||
| Philadelphia Union | 5-1 | Orlando City | |||
| 39(og) | João Moutinho | 75 | Perea | ||
| 43 | Uhre | ||||
| 55(p) | Gazdag | ||||
| 63 | Bedoya | ||||
| 87 | Elliott | ||||
| Nashville | 1-1 | LA Galaxy | |||
| 29(p) | Mukhtar | 90(p) | Riqui Puig | ||
| Atlanta United | 4-2 | Toronto FC | |||
| 47 | Sánchez | 52 | Akinola | ||
| 62 | Sánchez | 67(p) | Bernardeschi | ||
| 74 | Almada | ||||
| 88 | Sánchez | ||||
| FC Cincinnati | 6-0 | San Jose Earthquakes | |||
| 45 | Barreal | ||||
| 47 | Brenner | ||||
| 71(p) | Acosta | ||||
| 77 | Kubo | ||||
| 90 | Brenner | ||||
| 90(p) | Brenner | ||||
| Charlotte FC | 1-0 | New York City | |||
| 5 | Rios | ||||
