Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 165 | 451 | 2.73 | 83 | 50.30% | 41 | 24.85% | 41 | 24.85% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | Philadelphia Union | 12 | 5 | 6 | 1 | 16 | 9 | +7 | 21 | OXXX | 7 | 3 | 4 | 0 | 8 | 3 | 5 | 2 | 2 | 1 | 8 | 6 | |
| 2 | 4 | New York City | 11 | 6 | 2 | 3 | 23 | 10 | +13 | 20 | WWOW | 7 | 5 | 1 | 1 | 20 | 7 | 4 | 1 | 1 | 2 | 3 | 3 | |
| 3 | 2 | CF Montréal | 12 | 6 | 2 | 4 | 23 | 21 | +2 | 20 | LWWW | 4 | 3 | 0 | 1 | 9 | 5 | 8 | 3 | 2 | 3 | 14 | 16 | |
| 4 | 2 | Orlando City | 12 | 6 | 2 | 4 | 14 | 15 | -1 | 20 | WLWL | 6 | 3 | 0 | 3 | 8 | 10 | 6 | 3 | 2 | 1 | 6 | 5 | |
| 5 | New York Red Bulls | 12 | 5 | 5 | 2 | 20 | 12 | +8 | 20 | XXXW | 6 | 0 | 4 | 2 | 6 | 8 | 6 | 5 | 1 | 0 | 14 | 4 | ||
| 6 | 2 | FC Cincinnati | 12 | 6 | 1 | 5 | 16 | 18 | -2 | 19 | WWWW | 5 | 2 | 0 | 3 | 9 | 8 | 7 | 4 | 1 | 2 | 7 | 10 | |
| 7 | Atlanta United | 11 | 4 | 3 | 4 | 17 | 16 | +1 | 15 | XWLL | 6 | 3 | 3 | 0 | 14 | 8 | 5 | 1 | 0 | 4 | 3 | 8 | ||
| 8 | D.C. United | 11 | 4 | 1 | 6 | 14 | 17 | -3 | 13 | LXWL | 7 | 3 | 0 | 4 | 10 | 10 | 4 | 1 | 1 | 2 | 4 | 7 | ||
| 9 | Charlotte FC | 12 | 4 | 1 | 7 | 10 | 15 | -5 | 13 | LWLO | 6 | 4 | 0 | 2 | 7 | 4 | 6 | 0 | 1 | 5 | 3 | 11 | ||
| 10 | Columbus Crew | 11 | 3 | 4 | 4 | 15 | 13 | +2 | 13 | LXWO | 5 | 3 | 0 | 2 | 9 | 4 | 6 | 0 | 4 | 2 | 6 | 9 | ||
| 11 | New England Revolution | 11 | 3 | 3 | 5 | 18 | 20 | -2 | 12 | XXWL | 6 | 3 | 1 | 2 | 9 | 7 | 5 | 0 | 2 | 3 | 9 | 13 | ||
| 12 | 1 | Inter Miami | 12 | 3 | 3 | 6 | 11 | 21 | -10 | 12 | OXLL | 6 | 2 | 2 | 2 | 8 | 10 | 6 | 1 | 1 | 4 | 3 | 11 | |
| 13 | 1 | Toronto FC | 12 | 3 | 2 | 7 | 16 | 23 | -7 | 11 | LLLL | 6 | 3 | 0 | 3 | 8 | 10 | 6 | 0 | 2 | 4 | 8 | 13 | |
| 14 | Chicago Fire | 12 | 2 | 5 | 5 | 11 | 16 | -5 | 11 | XLLL | 6 | 1 | 3 | 2 | 5 | 5 | 6 | 1 | 2 | 3 | 6 | 11 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | Austin FC | 12 | 7 | 2 | 3 | 25 | 12 | +13 | 23 | WLLW | 6 | 4 | 1 | 1 | 15 | 3 | 6 | 3 | 1 | 2 | 10 | 9 | |
| 2 | 1 | Los Angeles | 12 | 7 | 2 | 3 | 24 | 14 | +10 | 23 | LLXW | 7 | 4 | 2 | 1 | 15 | 7 | 5 | 3 | 0 | 2 | 9 | 7 | |
| 3 | 1 | FC Dallas | 12 | 6 | 4 | 2 | 20 | 10 | +10 | 22 | LWWX | 6 | 5 | 1 | 0 | 14 | 4 | 6 | 1 | 3 | 2 | 6 | 6 | |
| 4 | LA Galaxy | 12 | 6 | 2 | 4 | 13 | 11 | +2 | 20 | XLWL | 5 | 3 | 0 | 2 | 5 | 5 | 7 | 3 | 2 | 2 | 8 | 6 | ||
| 5 | Real Salt Lake | 12 | 5 | 4 | 3 | 12 | 16 | -4 | 19 | WLWO | 5 | 4 | 1 | 0 | 8 | 4 | 7 | 1 | 3 | 3 | 4 | 12 | ||
| 6 | 2 | Nashville | 12 | 5 | 3 | 4 | 13 | 13 | +0 | 18 | WLWX | 3 | 2 | 1 | 0 | 5 | 2 | 9 | 3 | 2 | 4 | 8 | 11 | |
| 7 | 1 | Houston Dynamo | 12 | 4 | 3 | 5 | 14 | 14 | +0 | 15 | LWLL | 8 | 3 | 3 | 2 | 10 | 8 | 4 | 1 | 0 | 3 | 4 | 6 | |
| 8 | 1 | Colorado Rapids | 12 | 4 | 3 | 5 | 14 | 14 | +0 | 15 | LWLW | 6 | 4 | 2 | 0 | 10 | 1 | 6 | 0 | 1 | 5 | 4 | 13 | |
| 9 | 1 | Minnesota United | 12 | 4 | 3 | 5 | 13 | 13 | +0 | 15 | XLLL | 7 | 3 | 2 | 2 | 10 | 6 | 5 | 1 | 1 | 3 | 3 | 7 | |
| 10 | 1 | Portland Timbers | 13 | 3 | 6 | 4 | 20 | 21 | -1 | 15 | LWXL | 6 | 2 | 3 | 1 | 12 | 8 | 7 | 1 | 3 | 3 | 8 | 13 | |
| 11 | 3 | Seattle Sounders | 10 | 4 | 1 | 5 | 13 | 14 | -1 | 13 | WWLL | 4 | 2 | 0 | 2 | 6 | 5 | 6 | 2 | 1 | 3 | 7 | 9 | |
| 12 | 1 | San Jose Earthquakes | 12 | 3 | 4 | 5 | 22 | 28 | -6 | 13 | WXWL | 7 | 3 | 3 | 1 | 16 | 15 | 5 | 0 | 1 | 4 | 6 | 13 | |
| 13 | 1 | Sporting Kansas City | 13 | 3 | 3 | 7 | 12 | 24 | -12 | 12 | WLOX | 6 | 3 | 2 | 1 | 7 | 5 | 7 | 0 | 1 | 6 | 5 | 19 | |
| 14 | 1 | Vancouver Whitecaps | 11 | 3 | 2 | 6 | 12 | 21 | -9 | 11 | WXWL | 6 | 3 | 2 | 1 | 9 | 7 | 5 | 0 | 0 | 5 | 3 | 14 | |
| 9 | Jesús FERREIRA (FC Dallas) | |
| 7 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| +1 | Valentín CASTELLANOS (New York City, 3p) | |
| Sebastián DRIUSSI (Austin FC, 1p) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| 6 | Dániel GAZDAG (Philadelphia Union, 1p) | |
| Djordje MIHAILOVIC (CF Montréal) | ||
| +2 | Adam BUKSA (New England Revolution) | |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| Leonardo CAMPANA (Inter Miami) | ||
| Diego RUBIO (Colorado Rapids, 1p) | ||
| 5 | +1 | Lewis MORGAN (New York Red Bulls, 2p) |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Ola KAMARA (D.C. United, 1p) | ||
| +1 | Carlos VELA (Los Angeles, 2p) | |
| Darwin QUINTERO (Houston Dynamo, 1p) | ||
| Taxiarchis FOUNTAS (D.C. United) | ||
| Luciano ACOSTA (FC Cincinnati, 2p) | ||
| +2 | Robin LOD (Minnesota United) |
| Sunday, 15 May 2022 | |||||
| Seattle Sounders | 3-1 | Minnesota United | |||
| 50(p) | Ruidíaz | 34 | Lod | ||
| 74 | Roldan | ||||
| 90 | Lodeiro | ||||
| Atlanta United | 2-2 | New England Revolution | |||
| 15 | Almada | 30 | Buksa | ||
| 63 | Luiz Araújo | 55 | Buksa | ||
| Wednesday, 18 May 2022 | |||||
| D.C. United | 0-2 | New York City | |||
| 6 | Callens | ||||
| 45(p) | Castellanos | ||||
| Houston Dynamo | 0-1 | Seattle Sounders | |||
| 28 | Ruidíaz | ||||
| New York Red Bulls | 3-3 | Chicago Fire | |||
| 20(p) | Morgan | 38 | Mueller | ||
| 58 | Harper | 49 | Omsberg | ||
| 90 | Klimala | 89 | Shaqiri | ||
| Sporting Kansas City | 2-1 | Colorado Rapids | |||
| 24 | Sallói | 29 | Lucas Esteves | ||
| 50 | Sallói | ||||
| Vancouver Whitecaps | 2-1 | FC Dallas | |||
| 71 | White | 45 | Arriola | ||
| 90(p) | Cavallini | ||||
| San Jose Earthquakes | 3-2 | Portland Timbers | |||
| 31 | Yueill | 18 | Paredes | ||
| 44 | Monteiro | 56 | Tuiloma | ||
| 80 | Monteiro | ||||
| Philadelphia Union | 0-0 | Inter Miami | |||
| Minnesota United | 1-1 | LA Galaxy | |||
| 87 | Lod | 83(p) | Kljestan | ||
| Los Angeles | 1-2 | Austin FC | |||
| 86(p) | Vela | 13 | Gabrielsen | ||
| 80 | Fagúndez | ||||
| Nashville | 2-1 | CF Montréal | |||
| 28 | Muyl | 55 | Kamara | ||
| 51 | Mukhtar | ||||
