Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 346 | 1,015 | 2.93 | 163 | 47.11% | 89 | 25.72% | 94 | 27.17% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 25 | 13 | 9 | 3 | 45 | 19 | +26 | 48 | WLWW | 13 | 8 | 5 | 0 | 30 | 7 | 12 | 5 | 4 | 3 | 15 | 12 | ||
| 2 | 1 | CF Montréal | 25 | 13 | 4 | 8 | 43 | 41 | +2 | 43 | WXWO | 12 | 6 | 2 | 4 | 20 | 16 | 13 | 7 | 2 | 4 | 23 | 25 | |
| 3 | 1 | New York City | 24 | 12 | 6 | 6 | 45 | 27 | +18 | 42 | LLOW | 12 | 8 | 3 | 1 | 30 | 12 | 12 | 4 | 3 | 5 | 15 | 15 | |
| 4 | New York Red Bulls | 25 | 10 | 7 | 8 | 38 | 31 | +7 | 37 | LOLW | 12 | 3 | 4 | 5 | 18 | 17 | 13 | 7 | 3 | 3 | 20 | 14 | ||
| 5 | Columbus Crew | 24 | 8 | 10 | 6 | 32 | 27 | +5 | 34 | XWLO | 12 | 5 | 3 | 4 | 16 | 11 | 12 | 3 | 7 | 2 | 16 | 16 | ||
| 6 | 2 | Orlando City | 25 | 9 | 6 | 10 | 28 | 36 | -8 | 33 | WLLL | 12 | 5 | 0 | 7 | 15 | 23 | 13 | 4 | 6 | 3 | 13 | 13 | |
| 7 | 2 | Inter Miami | 25 | 9 | 6 | 10 | 32 | 41 | -9 | 33 | WXWX | 13 | 7 | 3 | 3 | 25 | 22 | 12 | 2 | 3 | 7 | 7 | 19 | |
| 8 | 2 | New England Revolution | 24 | 8 | 9 | 7 | 36 | 34 | +2 | 33 | WWOO | 12 | 5 | 5 | 2 | 16 | 12 | 12 | 3 | 4 | 5 | 20 | 22 | |
| 9 | 3 | FC Cincinnati | 25 | 8 | 9 | 8 | 42 | 45 | -3 | 33 | XWXX | 13 | 4 | 5 | 4 | 25 | 22 | 12 | 4 | 4 | 4 | 17 | 23 | |
| 10 | 3 | Chicago Fire | 25 | 8 | 6 | 11 | 28 | 34 | -6 | 30 | LWOW | 12 | 5 | 4 | 3 | 12 | 8 | 13 | 3 | 2 | 8 | 16 | 26 | |
| 11 | Charlotte FC | 25 | 9 | 2 | 14 | 30 | 39 | -9 | 29 | LLWL | 12 | 8 | 0 | 4 | 20 | 10 | 13 | 1 | 2 | 10 | 10 | 29 | ||
| 12 | 1 | Toronto FC | 25 | 8 | 5 | 12 | 37 | 43 | -6 | 29 | WWOW | 13 | 7 | 1 | 5 | 23 | 20 | 12 | 1 | 4 | 7 | 14 | 23 | |
| 13 | 1 | Atlanta United | 24 | 7 | 8 | 9 | 33 | 36 | -3 | 29 | XWOL | 12 | 6 | 4 | 2 | 22 | 16 | 12 | 1 | 4 | 7 | 11 | 20 | |
| 14 | D.C. United | 24 | 6 | 4 | 14 | 28 | 48 | -20 | 22 | LOLW | 13 | 4 | 3 | 6 | 18 | 20 | 11 | 2 | 1 | 8 | 10 | 28 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 24 | 17 | 3 | 4 | 53 | 24 | +29 | 54 | WWWW | 13 | 10 | 2 | 1 | 33 | 13 | 11 | 7 | 1 | 3 | 20 | 11 | ||
| 2 | Austin FC | 25 | 14 | 6 | 5 | 54 | 34 | +20 | 48 | WXWL | 12 | 6 | 4 | 2 | 32 | 18 | 13 | 8 | 2 | 3 | 22 | 16 | ||
| 3 | FC Dallas | 26 | 10 | 9 | 7 | 38 | 28 | +10 | 39 | WXLW | 13 | 7 | 3 | 3 | 22 | 12 | 13 | 3 | 6 | 4 | 16 | 16 | ||
| 4 | Minnesota United | 24 | 10 | 5 | 9 | 38 | 34 | +4 | 35 | LXWW | 12 | 5 | 4 | 3 | 20 | 14 | 12 | 5 | 1 | 6 | 18 | 20 | ||
| 5 | Real Salt Lake | 24 | 9 | 7 | 8 | 31 | 33 | -2 | 34 | LXLW | 12 | 7 | 3 | 2 | 19 | 11 | 12 | 2 | 4 | 6 | 12 | 22 | ||
| 6 | 3 | LA Galaxy | 24 | 10 | 3 | 11 | 37 | 34 | +3 | 33 | WLLW | 13 | 7 | 1 | 5 | 25 | 18 | 11 | 3 | 2 | 6 | 12 | 16 | |
| 7 | 1 | Nashville | 25 | 8 | 9 | 8 | 33 | 34 | -1 | 33 | LXXX | 11 | 3 | 5 | 3 | 16 | 15 | 14 | 5 | 4 | 5 | 17 | 19 | |
| 8 | 1 | Portland Timbers | 26 | 7 | 12 | 7 | 42 | 40 | +2 | 33 | LXXX | 13 | 5 | 6 | 2 | 22 | 15 | 13 | 2 | 6 | 5 | 20 | 25 | |
| 9 | 1 | Seattle Sounders | 24 | 10 | 2 | 12 | 31 | 29 | +2 | 32 | LWLW | 12 | 7 | 1 | 4 | 20 | 13 | 12 | 3 | 1 | 8 | 11 | 16 | |
| 10 | Colorado Rapids | 24 | 8 | 7 | 9 | 35 | 37 | -2 | 31 | XWWL | 13 | 7 | 4 | 2 | 22 | 12 | 11 | 1 | 3 | 7 | 13 | 25 | ||
| 11 | Vancouver Whitecaps | 25 | 8 | 6 | 11 | 29 | 44 | -15 | 30 | LWXL | 12 | 6 | 3 | 3 | 16 | 15 | 13 | 2 | 3 | 8 | 13 | 29 | ||
| 12 | Houston Dynamo | 25 | 7 | 4 | 14 | 31 | 42 | -11 | 25 | LLLL | 13 | 4 | 4 | 5 | 18 | 17 | 12 | 3 | 0 | 9 | 13 | 25 | ||
| 13 | San Jose Earthquakes | 25 | 5 | 9 | 11 | 40 | 53 | -13 | 24 | LXLX | 12 | 4 | 5 | 3 | 22 | 22 | 13 | 1 | 4 | 8 | 18 | 31 | ||
| 14 | Sporting Kansas City | 26 | 6 | 5 | 15 | 26 | 48 | -22 | 23 | LWLL | 12 | 4 | 2 | 6 | 12 | 15 | 14 | 2 | 3 | 9 | 14 | 33 | ||
| 17 | +1 | Sebastián DRIUSSI (Austin FC, 2p) |
| 15 | +1 | Brandon VÁZQUEZ (FC Cincinnati) |
| 14 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| +2 | Jesús FERREIRA (FC Dallas) | |
| 13 | Valentín CASTELLANOS (New York City, 5p) | |
| Hany MUKHTAR (Nashville, 3p) | ||
| 12 | +1 | Cristian ARANGO (Los Angeles, 1p) |
| +1 | Dániel GAZDAG (Philadelphia Union, 3p) | |
| +1 | Rommel QUIOTO (CF Montréal, 4p) | |
| +1 | Diego RUBIO (Colorado Rapids, 3p) | |
| 11 | Taxiarchis FOUNTAS (D.C. United) | |
| 10 | Lewis MORGAN (New York Red Bulls, 5p) | |
| +1 | Javier HERNÁNDEZ (LA Galaxy, 2p) | |
| 9 | Jarosław NIEZGODA (Portland Timbers) | |
| Dejan JOVELJIĆ (LA Galaxy, 1p) | ||
| +1 | Julián CARRANZA (Philadelphia Union, 1p) | |
| +1 | BRENNER Souza (FC Cincinnati) | |
| Paul ARRIOLA (FC Dallas) | ||
| Emanuel REYNOSO (Minnesota United, 2p) | ||
| +1 | Jonathan OSORIO (Toronto FC) | |
| 8 | Lucas CAVALLINI (Vancouver Whitecaps, 2p) | |
| Lucas ZELARAYÁN (Columbus Crew, 1p) | ||
| +1 | Sebastián FERREIRA (Houston Dynamo) | |
| Luis AMARILLA (Minnesota United) | ||
| +1 | Carlos VELA (Los Angeles, 2p) | |
| Leonardo CAMPANA (Inter Miami) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| Gonzalo HIGUAÍN (Inter Miami, 3p) | ||
| Mikael UHRE (Philadelphia Union) |
| Saturday, 13 August 2022 | |||||
| FC Dallas | 4-1 | San Jose Earthquakes | |||
| 3 | Ferreira | 60 | Ebobisse | ||
| 20 | Farfan | ||||
| 41 | Ferreira | ||||
| 57 | Velasco | ||||
| Houston Dynamo | 2-3 | CF Montréal | |||
| 12 | Ferreira | 15(p) | Quioto | ||
| 36 | Steres | 28 | Johnston | ||
| 69 | Lappalainen | ||||
| Colorado Rapids | 1-1 | Columbus Crew | |||
| 41(p) | Rubio | 5 | Cucho | ||
| New York Red Bulls | 0-1 | Orlando City | |||
| 17 | Torres | ||||
| New England Revolution | 1-0 | D.C. United | |||
| 18 | Carles Gil | ||||
| LA Galaxy | 5-2 | Vancouver Whitecaps | |||
| 12 | Grandsir | 38 | Gauld | ||
| 20(p) | Hernández | 70 | Ricketts | ||
| 30 | Víctor Vázquez | ||||
| 40 | Grandsir | ||||
| 89 | Álvarez | ||||
| Toronto FC | 3-1 | Portland Timbers | |||
| 41 | Osorio | 73 | van Rankin | ||
| 79 | Insigne | ||||
| 85 | Bernardeschi | ||||
| Philadelphia Union | 4-1 | Chicago Fire | |||
| 16 | Gazdag | 49 | Mueller | ||
| 37 | Elliott | ||||
| 53 | Carranza | ||||
| 82 | Burke | ||||
| Los Angeles | 5-0 | Charlotte FC | |||
| 49 | Murillo | ||||
| 59 | Cifuentes | ||||
| 73 | Vela | ||||
| 76 | Arango | ||||
| 90(og) | Walkes | ||||
| Austin FC | 4-3 | Sporting Kansas City | |||
| 27 | Gallagher | 12 | Fontás | ||
| 63 | Cascante | 23 | Agada | ||
| 85 | Hoesen | 40(p) | Russell | ||
| 90 | Driussi | ||||
| FC Cincinnati | 2-2 | Atlanta United | |||
| 29 | Vázquez | 17 | Almada | ||
| 41 | Brenner | 83 | Gutman | ||
| Inter Miami | 3-2 | New York City | |||
| 39 | Pozuelo | 34 | Talles Magno | ||
| 63 | Lassiter | 45 | Thiago Andrade | ||
| 84 | Pozuelo | ||||
