Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 363 | 1,068 | 2.94 | 170 | 46.83% | 94 | 25.90% | 99 | 27.27% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 27 | 14 | 9 | 4 | 51 | 20 | +31 | 51 | WLWL | 13 | 8 | 5 | 0 | 30 | 7 | 14 | 6 | 4 | 4 | 21 | 13 | ||
| 2 | CF Montréal | 26 | 14 | 4 | 8 | 47 | 41 | +6 | 46 | WWXW | 13 | 7 | 2 | 4 | 24 | 16 | 13 | 7 | 2 | 4 | 23 | 25 | ||
| 3 | New York City | 25 | 12 | 6 | 7 | 46 | 30 | +16 | 42 | LLLO | 13 | 8 | 3 | 2 | 31 | 15 | 12 | 4 | 3 | 5 | 15 | 15 | ||
| 4 | New York Red Bulls | 27 | 11 | 8 | 8 | 41 | 33 | +8 | 41 | XWLO | 13 | 3 | 5 | 5 | 19 | 18 | 14 | 8 | 3 | 3 | 22 | 15 | ||
| 5 | 2 | Inter Miami | 26 | 10 | 6 | 10 | 34 | 42 | -8 | 36 | WWXW | 14 | 8 | 3 | 3 | 27 | 23 | 12 | 2 | 3 | 7 | 7 | 19 | |
| 6 | 1 | Columbus Crew | 24 | 8 | 10 | 6 | 32 | 27 | +5 | 34 | XWLO | 12 | 5 | 3 | 4 | 16 | 11 | 12 | 3 | 7 | 2 | 16 | 16 | |
| 7 | 1 | New England Revolution | 26 | 8 | 10 | 8 | 38 | 40 | -2 | 34 | LXWW | 12 | 5 | 5 | 2 | 16 | 12 | 14 | 3 | 5 | 6 | 22 | 28 | |
| 8 | 1 | FC Cincinnati | 26 | 8 | 10 | 8 | 43 | 46 | -3 | 34 | XXWX | 13 | 4 | 5 | 4 | 25 | 22 | 13 | 4 | 5 | 4 | 18 | 24 | |
| 9 | 3 | Orlando City | 25 | 9 | 6 | 10 | 28 | 36 | -8 | 33 | WLLL | 12 | 5 | 0 | 7 | 15 | 23 | 13 | 4 | 6 | 3 | 13 | 13 | |
| 10 | 1 | Charlotte FC | 26 | 10 | 2 | 14 | 33 | 40 | -7 | 32 | WLLW | 12 | 8 | 0 | 4 | 20 | 10 | 14 | 2 | 2 | 10 | 13 | 30 | |
| 11 | 1 | Chicago Fire | 25 | 8 | 6 | 11 | 28 | 34 | -6 | 30 | LWOW | 12 | 5 | 4 | 3 | 12 | 8 | 13 | 3 | 2 | 8 | 16 | 26 | |
| 12 | Toronto FC | 27 | 8 | 6 | 13 | 40 | 47 | -7 | 30 | LXWW | 14 | 7 | 2 | 5 | 25 | 22 | 13 | 1 | 4 | 8 | 15 | 25 | ||
| 13 | Atlanta United | 25 | 7 | 8 | 10 | 34 | 38 | -4 | 29 | LXWO | 13 | 6 | 4 | 3 | 23 | 18 | 12 | 1 | 4 | 7 | 11 | 20 | ||
| 14 | D.C. United | 26 | 6 | 4 | 16 | 28 | 55 | -27 | 22 | LLLO | 14 | 4 | 3 | 7 | 18 | 26 | 12 | 2 | 1 | 9 | 10 | 29 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 26 | 18 | 3 | 5 | 55 | 26 | +29 | 57 | LWWW | 14 | 11 | 2 | 1 | 34 | 13 | 12 | 7 | 1 | 4 | 21 | 13 | ||
| 2 | Austin FC | 26 | 14 | 6 | 6 | 55 | 36 | +19 | 48 | LWXW | 12 | 6 | 4 | 2 | 32 | 18 | 14 | 8 | 2 | 4 | 23 | 18 | ||
| 3 | FC Dallas | 27 | 11 | 9 | 7 | 39 | 28 | +11 | 42 | WWXL | 14 | 8 | 3 | 3 | 23 | 12 | 13 | 3 | 6 | 4 | 16 | 16 | ||
| 4 | Minnesota United | 26 | 12 | 5 | 9 | 42 | 36 | +6 | 41 | WWLX | 13 | 6 | 4 | 3 | 22 | 15 | 13 | 6 | 1 | 6 | 20 | 21 | ||
| 5 | Real Salt Lake | 26 | 10 | 8 | 8 | 34 | 35 | -1 | 38 | XWLX | 13 | 7 | 4 | 2 | 20 | 12 | 13 | 3 | 4 | 6 | 14 | 23 | ||
| 6 | LA Galaxy | 25 | 10 | 4 | 11 | 40 | 37 | +3 | 34 | XWLL | 14 | 7 | 2 | 5 | 28 | 21 | 11 | 3 | 2 | 6 | 12 | 16 | ||
| 7 | 4 | Vancouver Whitecaps | 27 | 9 | 7 | 11 | 32 | 46 | -14 | 34 | XWLW | 13 | 7 | 3 | 3 | 18 | 16 | 14 | 2 | 4 | 8 | 14 | 30 | |
| 8 | 1 | Seattle Sounders | 26 | 10 | 3 | 13 | 35 | 34 | +1 | 33 | XLLW | 13 | 7 | 1 | 5 | 21 | 15 | 13 | 3 | 2 | 8 | 14 | 19 | |
| 9 | 2 | Nashville | 26 | 8 | 9 | 9 | 34 | 36 | -2 | 33 | LLXX | 12 | 3 | 5 | 4 | 17 | 17 | 14 | 5 | 4 | 5 | 17 | 19 | |
| 10 | 2 | Portland Timbers | 26 | 7 | 12 | 7 | 42 | 40 | +2 | 33 | LXXX | 13 | 5 | 6 | 2 | 22 | 15 | 13 | 2 | 6 | 5 | 20 | 25 | |
| 11 | 1 | Colorado Rapids | 26 | 8 | 8 | 10 | 37 | 40 | -3 | 32 | XLXW | 14 | 7 | 5 | 2 | 23 | 13 | 12 | 1 | 3 | 8 | 14 | 27 | |
| 12 | 1 | San Jose Earthquakes | 26 | 6 | 9 | 11 | 42 | 54 | -12 | 27 | WLXL | 13 | 5 | 5 | 3 | 24 | 23 | 13 | 1 | 4 | 8 | 18 | 31 | |
| 13 | 1 | Houston Dynamo | 26 | 7 | 5 | 14 | 32 | 43 | -11 | 26 | XLLL | 13 | 4 | 4 | 5 | 18 | 17 | 13 | 3 | 1 | 9 | 14 | 26 | |
| 14 | Sporting Kansas City | 26 | 6 | 5 | 15 | 26 | 48 | -22 | 23 | LWLL | 12 | 4 | 2 | 6 | 12 | 15 | 14 | 2 | 3 | 9 | 14 | 33 | ||
| 18 | +1 | Sebastián DRIUSSI (Austin FC, 3p) |
| 15 | +1 | Jesús FERREIRA (FC Dallas) |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 14 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| +1 | Hany MUKHTAR (Nashville, 3p) | |
| +2 | Rommel QUIOTO (CF Montréal, 4p) | |
| 13 | +1 | Dániel GAZDAG (Philadelphia Union, 4p) |
| Valentín CASTELLANOS (New York City, 5p) | ||
| 12 | +3 | Julián CARRANZA (Philadelphia Union, 1p) |
| Cristian ARANGO (Los Angeles, 1p) | ||
| Diego RUBIO (Colorado Rapids, 3p) | ||
| 11 | +1 | Lewis MORGAN (New York Red Bulls, 5p) |
| +1 | Javier HERNÁNDEZ (LA Galaxy, 2p) | |
| Taxiarchis FOUNTAS (D.C. United) | ||
| 10 | +1 | Dejan JOVELJIĆ (LA Galaxy, 2p) |
| +1 | Emanuel REYNOSO (Minnesota United, 3p) | |
| 9 | Jarosław NIEZGODA (Portland Timbers) | |
| BRENNER Souza (FC Cincinnati) | ||
| +1 | Sebastián FERREIRA (Houston Dynamo) | |
| Paul ARRIOLA (FC Dallas) | ||
| Jonathan OSORIO (Toronto FC) | ||
| +1 | Mikael UHRE (Philadelphia Union) |
| Sunday, 14 August 2022 | |||||
| Seattle Sounders | 1-2 | Real Salt Lake | |||
| 62 | Rusnák | 32 | Córdova | ||
| 64 | Brody | ||||
| Nashville | 1-2 | Minnesota United | |||
| 61 | Mukhtar | 27 | Fragapane | ||
| 75 | Benítez | ||||
| Tuesday, 16 August 2022 | |||||
| Los Angeles | 1-0 | D.C. United | |||
| 67 | Opoku | ||||
| Wednesday, 17 August 2022 | |||||
| FC Dallas | 1-0 | Philadelphia Union | |||
| 34 | Ferreira | ||||
| Vancouver Whitecaps | 2-1 | Colorado Rapids | |||
| 14 | Gauld | 76 | Zardes | ||
| 40 | Gauld | ||||
| Toronto FC | 2-2 | New England Revolution | |||
| 31(p) | Bernardeschi | 37 | McNamara | ||
| 75 | Criscito | 48 | Rennicks | ||
| New York City | 1-3 | Charlotte FC | |||
| 28 | Chanot | 4 | Świderski | ||
| 77 | Bronico | ||||
| 90(p) | Fuchs | ||||
| Atlanta United | 1-2 | New York Red Bulls | |||
| 90 | Martínez | 11 | Morgan | ||
| 15 | Tolkin | ||||
| Friday, 19 August 2022 | |||||
| LA Galaxy | 3-3 | Seattle Sounders | |||
| 10 | Hernández | 53 | Rowe | ||
| 42 | Víctor Vázquez | 61 | Ruidíaz | ||
| 90(p) | Joveljić | 73 | Morris | ||
| Saturday, 20 August 2022 | |||||
| D.C. United | 0-6 | Philadelphia Union | |||
| 37 | Uhre | ||||
| 45(p) | Gazdag | ||||
| 47 | Carranza | ||||
| 70 | Carranza | ||||
| 74 | Carranza | ||||
| 79 | Burke | ||||
| Colorado Rapids | 1-1 | Houston Dynamo | |||
| 48 | Abubakar | 90 | Ferreira | ||
| New York Red Bulls | 1-1 | FC Cincinnati | |||
| 23(p) | Klimala | 13 | Miazga | ||
| CF Montréal | 4-0 | New England Revolution | |||
| 26 | Kamara | ||||
| 39 | Quioto | ||||
| 55 | Quioto | ||||
| 90(p) | Miljevic | ||||
| Real Salt Lake | 1-1 | Vancouver Whitecaps | |||
| 61 | Córdova | 87 | Gressel | ||
| San Jose Earthquakes | 2-1 | Los Angeles | |||
| 14 | Kikanovic | 54 | Opoku | ||
| 77 | Cowell | ||||
| Minnesota United | 2-1 | Austin FC | |||
| 25(p) | Reynoso | 45(p) | Driussi | ||
| 62 | Fragapane | ||||
| Inter Miami | 2-1 | Toronto FC | |||
| 24 | Jean Mota | 28 | Insigne | ||
| 44 | Lassiter | ||||
