Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 209 | 574 | 2.74 | 102 | 48.80% | 52 | 24.88% | 55 | 26.32% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York City | 13 | 8 | 2 | 3 | 25 | 10 | +15 | 26 | WWWW | 8 | 6 | 1 | 1 | 21 | 7 | 5 | 2 | 1 | 2 | 4 | 3 | ||
| 2 | 2 | New York Red Bulls | 16 | 7 | 5 | 4 | 26 | 17 | +9 | 26 | WLWL | 8 | 2 | 4 | 2 | 12 | 9 | 8 | 5 | 1 | 2 | 14 | 8 | |
| 3 | 1 | Philadelphia Union | 15 | 6 | 8 | 1 | 20 | 11 | +9 | 26 | XXWO | 8 | 3 | 5 | 0 | 9 | 4 | 7 | 3 | 3 | 1 | 11 | 7 | |
| 4 | 1 | Orlando City | 16 | 7 | 4 | 5 | 20 | 22 | -2 | 25 | WXLX | 8 | 4 | 0 | 4 | 11 | 14 | 8 | 3 | 4 | 1 | 9 | 8 | |
| 5 | 2 | CF Montréal | 15 | 7 | 2 | 6 | 28 | 27 | +1 | 23 | LWLL | 7 | 4 | 0 | 3 | 14 | 11 | 8 | 3 | 2 | 3 | 14 | 16 | |
| 6 | 2 | Charlotte FC | 16 | 6 | 2 | 8 | 16 | 19 | -3 | 20 | XWLW | 8 | 6 | 0 | 2 | 11 | 5 | 8 | 0 | 2 | 6 | 5 | 14 | |
| 7 | 1 | FC Cincinnati | 15 | 6 | 2 | 7 | 22 | 26 | -4 | 20 | XLLW | 6 | 2 | 0 | 4 | 11 | 11 | 9 | 4 | 2 | 3 | 11 | 15 | |
| 8 | 3 | New England Revolution | 15 | 5 | 5 | 5 | 25 | 25 | +0 | 20 | XWXW | 8 | 3 | 3 | 2 | 11 | 9 | 7 | 2 | 2 | 3 | 14 | 16 | |
| 9 | 2 | Inter Miami | 14 | 5 | 3 | 6 | 15 | 22 | -7 | 18 | WWOX | 8 | 4 | 2 | 2 | 12 | 11 | 6 | 1 | 1 | 4 | 3 | 11 | |
| 10 | 1 | Columbus Crew | 14 | 4 | 5 | 5 | 18 | 17 | +1 | 17 | XWLL | 7 | 3 | 1 | 3 | 10 | 7 | 7 | 1 | 4 | 2 | 8 | 10 | |
| 11 | 1 | Atlanta United | 13 | 4 | 4 | 5 | 20 | 20 | +0 | 16 | LXXW | 7 | 3 | 3 | 1 | 15 | 10 | 6 | 1 | 1 | 4 | 5 | 10 | |
| 12 | Toronto FC | 15 | 4 | 3 | 8 | 21 | 29 | -8 | 15 | LWXL | 7 | 4 | 0 | 3 | 11 | 12 | 8 | 0 | 3 | 5 | 10 | 17 | ||
| 13 | D.C. United | 14 | 4 | 2 | 8 | 17 | 24 | -7 | 14 | LLXL | 8 | 3 | 1 | 4 | 12 | 12 | 6 | 1 | 1 | 4 | 5 | 12 | ||
| 14 | Chicago Fire | 15 | 3 | 5 | 7 | 14 | 20 | -6 | 14 | WLLX | 7 | 2 | 3 | 2 | 6 | 5 | 8 | 1 | 2 | 5 | 8 | 15 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 15 | 9 | 3 | 3 | 30 | 17 | +13 | 30 | XWWL | 8 | 5 | 2 | 1 | 18 | 9 | 7 | 4 | 1 | 2 | 12 | 8 | ||
| 2 | 1 | Real Salt Lake | 16 | 8 | 4 | 4 | 20 | 19 | +1 | 28 | WLWW | 7 | 6 | 1 | 0 | 13 | 4 | 9 | 2 | 3 | 4 | 7 | 15 | |
| 3 | 1 | Austin FC | 15 | 8 | 3 | 4 | 29 | 18 | +11 | 27 | WLXW | 7 | 4 | 2 | 1 | 17 | 5 | 8 | 4 | 1 | 3 | 12 | 13 | |
| 4 | 2 | FC Dallas | 15 | 7 | 4 | 4 | 24 | 15 | +9 | 25 | LWLL | 8 | 5 | 1 | 2 | 15 | 8 | 7 | 2 | 3 | 2 | 9 | 7 | |
| 5 | LA Galaxy | 15 | 7 | 3 | 5 | 18 | 16 | +2 | 24 | XWLX | 8 | 4 | 1 | 3 | 10 | 10 | 7 | 3 | 2 | 2 | 8 | 6 | ||
| 6 | Nashville | 15 | 6 | 5 | 4 | 18 | 16 | +2 | 23 | OWXW | 5 | 2 | 3 | 0 | 7 | 4 | 10 | 4 | 2 | 4 | 11 | 12 | ||
| 7 | 3 | Seattle Sounders | 14 | 6 | 2 | 6 | 20 | 17 | +3 | 20 | XWWL | 7 | 4 | 1 | 2 | 13 | 7 | 7 | 2 | 1 | 4 | 7 | 10 | |
| 8 | 4 | Vancouver Whitecaps | 16 | 6 | 2 | 8 | 18 | 28 | -10 | 20 | WLWW | 7 | 4 | 2 | 1 | 11 | 8 | 9 | 2 | 0 | 7 | 7 | 20 | |
| 9 | 1 | Minnesota United | 14 | 5 | 3 | 6 | 15 | 15 | +0 | 18 | LWXL | 8 | 3 | 2 | 3 | 10 | 7 | 6 | 2 | 1 | 3 | 5 | 8 | |
| 10 | 3 | Houston Dynamo | 15 | 5 | 3 | 7 | 18 | 19 | -1 | 18 | LLWL | 8 | 3 | 3 | 2 | 10 | 8 | 7 | 2 | 0 | 5 | 8 | 11 | |
| 11 | 2 | Colorado Rapids | 14 | 5 | 3 | 6 | 16 | 17 | -1 | 18 | LWLW | 8 | 5 | 2 | 1 | 12 | 4 | 6 | 0 | 1 | 5 | 4 | 13 | |
| 12 | 1 | Portland Timbers | 16 | 3 | 7 | 6 | 22 | 26 | -4 | 16 | XLLL | 7 | 2 | 3 | 2 | 12 | 10 | 9 | 1 | 4 | 4 | 10 | 16 | |
| 13 | San Jose Earthquakes | 16 | 3 | 6 | 7 | 25 | 34 | -9 | 15 | LOLX | 8 | 3 | 4 | 1 | 17 | 16 | 8 | 0 | 2 | 6 | 8 | 18 | ||
| 14 | Sporting Kansas City | 16 | 3 | 4 | 9 | 14 | 28 | -14 | 13 | LLXW | 8 | 3 | 2 | 3 | 8 | 8 | 8 | 0 | 2 | 6 | 6 | 20 | ||
| 9 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| Jesús FERREIRA (FC Dallas) | ||
| 8 | Sebastián DRIUSSI (Austin FC, 2p) | |
| +1 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 7 | +1 | Lewis MORGAN (New York Red Bulls, 2p) |
| Dániel GAZDAG (Philadelphia Union, 1p) | ||
| Valentín CASTELLANOS (New York City, 3p) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| Paul ARRIOLA (FC Dallas) | ||
| Adam BUKSA (New England Revolution) | ||
| Leonardo CAMPANA (Inter Miami) | ||
| Diego RUBIO (Colorado Rapids, 1p) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| 6 | Javier HERNÁNDEZ (LA Galaxy) | |
| Hany MUKHTAR (Nashville) | ||
| +1 | Sebastián FERREIRA (Houston Dynamo) | |
| +2 | Ercan KARA (Orlando City) | |
| Ola KAMARA (D.C. United, 1p) | ||
| Carlos VELA (Los Angeles, 2p) | ||
| Robin LOD (Minnesota United) |
| Saturday, 4 June 2022 | |||||
| Vancouver Whitecaps | 2-1 | Real Salt Lake | |||
| 31 | Veselinović | 52 | Meram | ||
| 90(p) | Gauld | ||||
| Saturday, 11 June 2022 | |||||
| Nashville | 0-0 | San Jose Earthquakes | |||
| Charlotte FC | 2-0 | New York Red Bulls | |||
| 45 | Bender | ||||
| 90 | Jones | ||||
| Sunday, 12 June 2022 | |||||
| Sporting Kansas City | 1-2 | New England Revolution | |||
| 52 | Russell | 30 | Bou | ||
| 87 | Boateng | ||||
| Tuesday, 14 June 2022 | |||||
| Seattle Sounders | 4-0 | Vancouver Whitecaps | |||
| 5(p) | Lodeiro | ||||
| 28 | Ruidíaz | ||||
| 54 | Ruidíaz | ||||
| 89 | Roldán | ||||
| Wednesday, 15 June 2022 | |||||
| New England Revolution | 1-1 | Orlando City | |||
| 22 | Carles Gil | 35 | Jansson | ||
| Saturday, 18 June 2022 | |||||
| FC Dallas | 0-2 | Vancouver Whitecaps | |||
| 2 | Cavallini | ||||
| 44 | Caicedo | ||||
| New York Red Bulls | 2-0 | Toronto FC | |||
| 2 | Morgan | ||||
| 56 | Luquinhas | ||||
| Columbus Crew | 1-1 | Charlotte FC | |||
| 41 | Hurtado | 49 | André Bava | ||
| LA Galaxy | 1-1 | Portland Timbers | |||
| 88 | Joveljić | 38 | Chará | ||
| Chicago Fire | 1-0 | D.C. United | |||
| 78 | Herbers | ||||
| CF Montréal | 0-1 | Austin FC | |||
| 67 | Urruti | ||||
| Seattle Sounders | 1-1 | Los Angeles | |||
| 58 | Rusnák | 79 | Arango | ||
| Real Salt Lake | 2-0 | San Jose Earthquakes | |||
| 22 | Silva | ||||
| 81 | Savarino | ||||
| Orlando City | 2-1 | Houston Dynamo | |||
| 25 | Kara | 59 | Ferreira | ||
| 58 | Kara | ||||
| Philadelphia Union | 1-1 | FC Cincinnati | |||
| 17 | Bedoya | 39 | Vázquez | ||
