Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 249 | 692 | 2.77 | 121 | 48.59% | 62 | 24.90% | 66 | 26.51% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 3 | New York Red Bulls | 19 | 9 | 5 | 5 | 29 | 20 | +9 | 32 | WWLW | 9 | 3 | 4 | 2 | 14 | 10 | 10 | 6 | 1 | 3 | 15 | 10 | |
| 2 | Philadelphia Union | 18 | 7 | 9 | 2 | 22 | 13 | +9 | 30 | OLWX | 9 | 4 | 5 | 0 | 11 | 5 | 9 | 3 | 4 | 2 | 11 | 8 | ||
| 3 | 2 | CF Montréal | 18 | 9 | 2 | 7 | 32 | 33 | -1 | 29 | LWWL | 8 | 5 | 0 | 3 | 16 | 12 | 10 | 4 | 2 | 4 | 16 | 21 | |
| 4 | 1 | New York City | 17 | 8 | 5 | 4 | 33 | 19 | +14 | 29 | XXLX | 10 | 6 | 3 | 1 | 24 | 10 | 7 | 2 | 2 | 3 | 9 | 9 | |
| 5 | 1 | FC Cincinnati | 18 | 7 | 4 | 7 | 29 | 32 | -3 | 25 | XXWX | 8 | 3 | 1 | 4 | 16 | 15 | 10 | 4 | 3 | 3 | 13 | 17 | |
| 6 | 1 | Orlando City | 18 | 7 | 4 | 7 | 23 | 28 | -5 | 25 | LLWX | 9 | 4 | 0 | 5 | 14 | 19 | 9 | 3 | 4 | 2 | 9 | 9 | |
| 7 | New England Revolution | 18 | 6 | 7 | 5 | 29 | 28 | +1 | 25 | XOWX | 10 | 4 | 4 | 2 | 15 | 12 | 8 | 2 | 3 | 3 | 14 | 16 | ||
| 8 | 2 | Charlotte FC | 19 | 7 | 2 | 10 | 19 | 23 | -4 | 23 | WLLX | 9 | 6 | 0 | 3 | 11 | 6 | 10 | 1 | 2 | 7 | 8 | 17 | |
| 9 | 1 | Inter Miami | 17 | 6 | 4 | 7 | 18 | 26 | -8 | 22 | XWLW | 9 | 5 | 2 | 2 | 14 | 12 | 8 | 1 | 2 | 5 | 4 | 14 | |
| 10 | 1 | Columbus Crew | 17 | 5 | 7 | 5 | 20 | 18 | +2 | 22 | OWOX | 8 | 3 | 2 | 3 | 10 | 7 | 9 | 2 | 5 | 2 | 10 | 11 | |
| 11 | Atlanta United | 17 | 5 | 5 | 7 | 26 | 26 | +0 | 20 | XLLW | 8 | 4 | 3 | 1 | 17 | 10 | 9 | 1 | 2 | 6 | 9 | 16 | ||
| 12 | Toronto FC | 18 | 5 | 3 | 10 | 24 | 34 | -10 | 18 | LLWL | 10 | 5 | 0 | 5 | 14 | 17 | 8 | 0 | 3 | 5 | 10 | 17 | ||
| 13 | 1 | D.C. United | 16 | 5 | 2 | 9 | 23 | 30 | -7 | 17 | WLLL | 9 | 3 | 1 | 5 | 13 | 15 | 7 | 2 | 1 | 4 | 10 | 15 | |
| 14 | 1 | Chicago Fire | 18 | 4 | 5 | 9 | 16 | 24 | -8 | 17 | LWLW | 8 | 3 | 3 | 2 | 7 | 5 | 10 | 1 | 2 | 7 | 9 | 19 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 18 | 11 | 3 | 4 | 35 | 19 | +16 | 36 | LWWX | 10 | 7 | 2 | 1 | 23 | 10 | 8 | 4 | 1 | 3 | 12 | 9 | ||
| 2 | 1 | Austin FC | 18 | 10 | 4 | 4 | 35 | 22 | +13 | 34 | WWXW | 8 | 4 | 3 | 1 | 19 | 7 | 10 | 6 | 1 | 3 | 16 | 15 | |
| 3 | 1 | Real Salt Lake | 18 | 8 | 5 | 5 | 22 | 22 | +0 | 29 | LOWL | 8 | 6 | 2 | 0 | 13 | 4 | 10 | 2 | 3 | 5 | 9 | 18 | |
| 4 | 2 | LA Galaxy | 17 | 8 | 3 | 6 | 24 | 19 | +5 | 27 | WLXW | 10 | 5 | 1 | 4 | 16 | 13 | 7 | 3 | 2 | 2 | 8 | 6 | |
| 5 | 1 | FC Dallas | 18 | 7 | 6 | 5 | 28 | 21 | +7 | 27 | XLXL | 9 | 5 | 2 | 2 | 16 | 9 | 9 | 2 | 4 | 3 | 12 | 12 | |
| 6 | 1 | Nashville | 18 | 7 | 6 | 5 | 24 | 21 | +3 | 27 | XWLO | 7 | 2 | 4 | 1 | 10 | 8 | 11 | 5 | 2 | 4 | 14 | 13 | |
| 7 | Seattle Sounders | 17 | 8 | 2 | 7 | 26 | 19 | +7 | 26 | WLWX | 9 | 5 | 1 | 3 | 17 | 9 | 8 | 3 | 1 | 4 | 9 | 10 | ||
| 8 | 2 | Minnesota United | 18 | 7 | 3 | 8 | 23 | 23 | +0 | 24 | WWLL | 9 | 4 | 2 | 3 | 13 | 9 | 9 | 3 | 1 | 5 | 10 | 14 | |
| 9 | 2 | Vancouver Whitecaps | 18 | 7 | 3 | 8 | 19 | 28 | -9 | 24 | WOWL | 9 | 5 | 3 | 1 | 12 | 8 | 9 | 2 | 0 | 7 | 7 | 20 | |
| 10 | 2 | Portland Timbers | 19 | 5 | 8 | 6 | 29 | 29 | +0 | 23 | XWWX | 9 | 4 | 3 | 2 | 17 | 11 | 10 | 1 | 5 | 4 | 12 | 18 | |
| 11 | 2 | Houston Dynamo | 18 | 6 | 3 | 9 | 22 | 23 | -1 | 21 | LLWL | 10 | 4 | 3 | 3 | 13 | 10 | 8 | 2 | 0 | 6 | 9 | 13 | |
| 12 | Colorado Rapids | 17 | 5 | 4 | 8 | 19 | 24 | -5 | 19 | LLXL | 9 | 5 | 2 | 2 | 14 | 7 | 8 | 0 | 2 | 6 | 5 | 17 | ||
| 13 | 1 | San Jose Earthquakes | 17 | 4 | 6 | 7 | 27 | 35 | -8 | 18 | WLOL | 9 | 4 | 4 | 1 | 19 | 17 | 8 | 0 | 2 | 6 | 8 | 18 | |
| 14 | 1 | Sporting Kansas City | 19 | 4 | 4 | 11 | 16 | 33 | -17 | 16 | LLWL | 9 | 3 | 2 | 4 | 8 | 9 | 10 | 1 | 2 | 7 | 8 | 24 | |
| 10 | +2 | Valentín CASTELLANOS (New York City, 4p) |
| Jesús FERREIRA (FC Dallas) | ||
| +1 | Sebastián DRIUSSI (Austin FC, 2p) | |
| 9 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| +1 | Hany MUKHTAR (Nashville) | |
| +3 | Taxiarchis FOUNTAS (D.C. United) | |
| 8 | +1 | Lewis MORGAN (New York Red Bulls, 3p) |
| Paul ARRIOLA (FC Dallas) | ||
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| +1 | Leonardo CAMPANA (Inter Miami) | |
| Jesús JIMÉNEZ (Toronto FC) | ||
| 7 | Dániel GAZDAG (Philadelphia Union, 1p) | |
| +1 | Javier HERNÁNDEZ (LA Galaxy) | |
| Djordje MIHAILOVIC (CF Montréal) | ||
| +1 | Ercan KARA (Orlando City) | |
| Adam BUKSA (New England Revolution) | ||
| Darwin QUINTERO (Houston Dynamo, 1p) | ||
| +2 | Emanuel REYNOSO (Minnesota United, 2p) | |
| Diego RUBIO (Colorado Rapids, 1p) | ||
| 6 | +1 | Jarosław NIEZGODA (Portland Timbers) |
| +1 | Maximiliano URRUTI (Austin FC) | |
| +1 | Dejan JOVELJIĆ (LA Galaxy, 1p) | |
| Cristian ARANGO (Los Angeles, 1p) | ||
| Sebastián FERREIRA (Houston Dynamo) | ||
| Ola KAMARA (D.C. United, 1p) | ||
| Carlos VELA (Los Angeles, 2p) | ||
| Rommel QUIOTO (CF Montréal, 2p) | ||
| Luciano ACOSTA (FC Cincinnati, 2p) | ||
| Robin LOD (Minnesota United) |
| Thursday, 30 June 2022 | |||||
| New York Red Bulls | 2-1 | Atlanta United | |||
| 83(p) | Morgan | 75 | Martínez | ||
| 89 | Ngoma | ||||
| Charlotte FC | 0-1 | Austin FC | |||
| 62 | Pereira | ||||
| Saturday, 2 July 2022 | |||||
| Vancouver Whitecaps | 1-0 | Los Angeles | |||
| 89 | Cubas | ||||
| Toronto FC | 0-2 | Seattle Sounders | |||
| 39 | Teves | ||||
| 60 | Montero | ||||
| Sunday, 3 July 2022 | |||||
| Houston Dynamo | 1-2 | Charlotte FC | |||
| 81 | Picault | 28(og) | Vera | ||
| 74 | André Bava | ||||
| Columbus Crew | 0-0 | Philadelphia Union | |||
| New England Revolution | 2-2 | FC Cincinnati | |||
| 30 | Borrero | 41(og) | Kessler | ||
| 55 | Bou | 73 | Brenner | ||
| Sporting Kansas City | 0-1 | New York Red Bulls | |||
| 53 | Long | ||||
| San Jose Earthquakes | 2-1 | Chicago Fire | |||
| 47 | Kikanovic | 90 | Gutiérrez | ||
| 87 | Kikanovic | ||||
| Minnesota United | 3-2 | Real Salt Lake | |||
| 9 | Reynoso | 71 | Savarino | ||
| 45 | Reynoso | 76 | Julio | ||
| 61 | Amarilla | ||||
| Nashville | 2-2 | Portland Timbers | |||
| 19 | Davis | 64(p) | Asprilla | ||
| 57 | Mukhtar | 69 | Niezgoda | ||
| New York City | 2-2 | Atlanta United | |||
| 37 | Castellanos | 56 | Martínez | ||
| 58 | Castellanos | 86 | Dwyer | ||
| Monday, 4 July 2022 | |||||
| FC Dallas | 1-1 | Inter Miami | |||
| 27 | Velasco | 89 | Campana | ||
| Colorado Rapids | 2-3 | Austin FC | |||
| 19 | Abubakar | 28 | Finlay | ||
| 22 | Lewis | 45 | Driussi | ||
| 59 | Urruti | ||||
| LA Galaxy | 4-0 | CF Montréal | |||
| 8 | Hernández | ||||
| 45(p) | Joveljić | ||||
| 60 | Raveloson | ||||
| 79 | Raveloson | ||||
| Orlando City | 3-5 | D.C. United | |||
| 57 | Torres | 5 | Fountas | ||
| 66 | Kara | 8 | Fountas | ||
| 80(p) | Alexandre Pato | 51 | Fountas | ||
| 74 | Smith | ||||
| 90 | Robertha | ||||
