Primera División| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | Apertura |
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | Clausura |
| Season archive |
| Wednesday, 3 November 2021 | |||||
| 10 | Nacional | - | Torque | ||
| 10 | River Plate | - | Wanderers | ||
| 10 | Liverpool | - | Rentistas | ||
| 10 | Deportivo Maldonado | - | Villa Española | ||
| Thursday, 4 November 2021 | |||||
| 10 | Cerrito | - | Peñarol | ||
| 10 | Progreso | - | Fénix | ||
| 10 | Sud América | - | Plaza Colonia | ||
| 10 | Cerro Largo | - | Boston River | ||
