| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | Apertura | 
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | Clausura | 
| Season archive | 
| Games | Goals | H | D | A | ||||
| 120 | 301 | 2.50 | 50 | 41.67% | 30 | 25.00% | 40 | 33.33% | 
| Apertura | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Plaza Colonia | 15 | 11 | 3 | 1 | 20 | 7 | +13 | 36 | WWOW | 7 | 4 | 2 | 1 | 8 | 4 | 8 | 7 | 1 | 0 | 12 | 3 | ||
| 2 | Nacional | 15 | 9 | 2 | 4 | 23 | 14 | +9 | 29 | LWLW | 8 | 7 | 0 | 1 | 16 | 3 | 7 | 2 | 2 | 3 | 7 | 11 | ||
| 3 | Peñarol | 15 | 7 | 7 | 1 | 22 | 10 | +12 | 28 | XWWW | 8 | 5 | 3 | 0 | 16 | 4 | 7 | 2 | 4 | 1 | 6 | 6 | ||
| 4 | Liverpool | 15 | 8 | 3 | 4 | 38 | 20 | +18 | 27 | WLXW | 7 | 5 | 2 | 0 | 23 | 8 | 8 | 3 | 1 | 4 | 15 | 12 | ||
| 5 | River Plate | 15 | 7 | 5 | 3 | 27 | 20 | +7 | 26 | WXXL | 7 | 3 | 3 | 1 | 13 | 7 | 8 | 4 | 2 | 2 | 14 | 13 | ||
| 6 | Torque | 15 | 8 | 1 | 6 | 26 | 19 | +7 | 25 | WWXL | 9 | 4 | 0 | 5 | 12 | 11 | 6 | 4 | 1 | 1 | 14 | 8 | ||
| 7 | 1 | Fénix | 15 | 6 | 3 | 6 | 20 | 22 | -2 | 21 | WWOL | 7 | 3 | 1 | 3 | 9 | 10 | 8 | 3 | 2 | 3 | 11 | 12 | |
| 8 | 2 | Cerro Largo | 15 | 6 | 2 | 7 | 20 | 22 | -2 | 20 | WLLW | 7 | 4 | 0 | 3 | 13 | 10 | 8 | 2 | 2 | 4 | 7 | 12 | |
| 9 | 2 | Cerrito | 15 | 5 | 4 | 6 | 14 | 15 | -1 | 19 | LOWX | 7 | 3 | 2 | 2 | 7 | 4 | 8 | 2 | 2 | 4 | 7 | 11 | |
| 10 | 1 | Sud América | 15 | 5 | 3 | 7 | 15 | 22 | -7 | 18 | XWWL | 7 | 2 | 3 | 2 | 8 | 9 | 8 | 3 | 0 | 5 | 7 | 13 | |
| 11 | 2 | Wanderers | 15 | 5 | 2 | 8 | 12 | 16 | -4 | 17 | LLLW | 8 | 4 | 2 | 2 | 8 | 4 | 7 | 1 | 0 | 6 | 4 | 12 | |
| 12 | Rentistas | 15 | 4 | 4 | 7 | 12 | 21 | -9 | 16 | LLXL | 8 | 1 | 1 | 6 | 5 | 15 | 7 | 3 | 3 | 1 | 7 | 6 | ||
| 13 | 1 | Boston River | 15 | 3 | 5 | 7 | 14 | 19 | -5 | 14 | WLOW | 7 | 2 | 2 | 3 | 7 | 8 | 8 | 1 | 3 | 4 | 7 | 11 | |
| 14 | 1 | Deportivo Maldonado | 15 | 3 | 5 | 7 | 11 | 22 | -11 | 14 | LOOL | 8 | 1 | 3 | 4 | 6 | 12 | 7 | 2 | 2 | 3 | 5 | 10 | |
| 15 | Progreso | 15 | 2 | 5 | 8 | 13 | 26 | -13 | 11 | LLXL | 7 | 1 | 2 | 4 | 7 | 14 | 8 | 1 | 3 | 4 | 6 | 12 | ||
| 16 | Villa Española | 15 | 1 | 6 | 8 | 14 | 26 | -12 | 9 | LXXX | 8 | 1 | 4 | 3 | 9 | 11 | 7 | 0 | 2 | 5 | 5 | 15 | ||
| 12 | Gonzalo BERGESSIO (Nacional, 2p) | |
| 11 | Juan RAMÍREZ (Liverpool, 3p) | |
| +1 | Douglas AREZO (River Plate, 4p) | |
| 10 | Maximiliano SILVERA (Cerrito, 3p) | |
| 9 | +2 | Federico MARTÍNEZ (Liverpool) | 
| 8 | Agustín ÁLVAREZ (Peñarol) | |
| 7 | +1 | Leandro OTORMÍN (Cerro Largo, 2p) | 
| 6 | +2 | DIOGO de Oliveira (Plaza Colonia, 1p) | 
| 5 | Thiago BORBAS (River Plate) | |
| +1 | Gustavo ALLES (Progreso) | |
| Sebastián FERNÁNDEZ (Liverpool, 1p) | ||
| +1 | Pablo CEPPELINI (Peñarol, 4p) | |
| +1 | Tomás ANDRADE (Sud América, 3p) | |
| 4 | Renzo LÓPEZ (Wanderers) | |
| Rubén BENTANCOURT (Boston River, 1p) | ||
| Gustavo DEL PRETE (Torque) | 
| Friday, 20 August 2021 | |||||
| 15 | Fénix | 2-1 | Wanderers | ||
| 50 | Pereira | 23 | Rivero | ||
| 71 | Rodríguez | ||||
| 15 | Progreso | 1-4 | Torque | ||
| 32 | Alles | 18 | Cejas | ||
| 30(p) | Allende | ||||
| 65 | Cejas | ||||
| 85 | Pérez | ||||
| Saturday, 21 August 2021 | |||||
| 15 | River Plate | 2-0 | Nacional | ||
| 45 | Arezo | ||||
| 51 | Boggio | ||||
| 15 | Liverpool | 3-0 | Cerrito | ||
| 23 | Martínez | ||||
| 44 | Martínez | ||||
| 57 | Figueredo | ||||
| 15 | Deportivo Maldonado | 0-2 | Boston River | ||
| 43 | Labandeira | ||||
| 81 | Freitas | ||||
| Sunday, 22 August 2021 | |||||
| 15 | Plaza Colonia | 2-0 | Rentistas | ||
| 23 | Diogo | ||||
| 78(p) | Diogo | ||||
| 15 | Sud América | 1-1 | Peñarol | ||
| 74(p) | Andrade | 37(p) | Ceppelini | ||
| 15 | Cerro Largo | 3-1 | Villa Española | ||
| 43 | Paiva | 60 | Albin | ||
| 50 | Onetto | ||||
| 90 | Otormín | ||||