| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | Apertura | 
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | Clausura | 
| Season archive | 
| Games | Goals | H | D | A | ||||
| 120 | 307 | 2.55 | 47 | 39.17% | 32 | 26.67% | 41 | 34.17% | 
| Clausura | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Peñarol | 15 | 9 | 5 | 1 | 27 | 11 | +16 | 32 | WOXX | 7 | 4 | 3 | 0 | 12 | 4 | 8 | 5 | 2 | 1 | 15 | 7 | ||
| 2 | Nacional | 15 | 9 | 3 | 3 | 23 | 15 | +8 | 30 | WXWL | 7 | 5 | 1 | 1 | 14 | 8 | 8 | 4 | 2 | 2 | 9 | 7 | ||
| 3 | Wanderers | 15 | 8 | 3 | 4 | 23 | 18 | +5 | 27 | XWWL | 7 | 4 | 1 | 2 | 10 | 6 | 8 | 4 | 2 | 2 | 13 | 12 | ||
| 4 | Cerro Largo | 15 | 6 | 8 | 1 | 24 | 11 | +13 | 26 | XXXX | 8 | 3 | 4 | 1 | 10 | 5 | 7 | 3 | 4 | 0 | 14 | 6 | ||
| 5 | 1 | Torque | 15 | 7 | 4 | 4 | 26 | 19 | +7 | 25 | WXXW | 6 | 3 | 2 | 1 | 14 | 8 | 9 | 4 | 2 | 3 | 12 | 11 | |
| 6 | 1 | Progreso | 15 | 7 | 4 | 4 | 12 | 7 | +5 | 25 | LOWW | 8 | 4 | 3 | 1 | 8 | 3 | 7 | 3 | 1 | 3 | 4 | 4 | |
| 7 | Boston River | 15 | 6 | 4 | 5 | 24 | 25 | -1 | 22 | WOWW | 8 | 4 | 1 | 3 | 12 | 13 | 7 | 2 | 3 | 2 | 12 | 12 | ||
| 8 | 1 | Cerrito | 15 | 6 | 3 | 6 | 20 | 22 | -2 | 21 | WWLW | 8 | 3 | 2 | 3 | 11 | 13 | 7 | 3 | 1 | 3 | 9 | 9 | |
| 9 | 1 | Plaza Colonia | 15 | 5 | 5 | 5 | 20 | 18 | +2 | 20 | WLLX | 8 | 3 | 3 | 2 | 12 | 8 | 7 | 2 | 2 | 3 | 8 | 10 | |
| 10 | 2 | Fénix | 15 | 4 | 7 | 4 | 18 | 18 | +0 | 19 | XOWX | 8 | 2 | 3 | 3 | 10 | 12 | 7 | 2 | 4 | 1 | 8 | 6 | |
| 11 | Deportivo Maldonado | 15 | 5 | 2 | 8 | 13 | 18 | -5 | 17 | LLLW | 7 | 4 | 0 | 3 | 7 | 7 | 8 | 1 | 2 | 5 | 6 | 11 | ||
| 12 | River Plate | 15 | 4 | 4 | 7 | 18 | 22 | -4 | 16 | LWXX | 8 | 3 | 2 | 3 | 12 | 11 | 7 | 1 | 2 | 4 | 6 | 11 | ||
| 13 | Liverpool | 15 | 4 | 3 | 8 | 15 | 19 | -4 | 15 | LXWL | 8 | 2 | 2 | 4 | 9 | 11 | 7 | 2 | 1 | 4 | 6 | 8 | ||
| 14 | Rentistas | 15 | 4 | 2 | 9 | 18 | 24 | -6 | 14 | LLLX | 7 | 2 | 0 | 5 | 8 | 10 | 8 | 2 | 2 | 4 | 10 | 14 | ||
| 15 | Sud América | 15 | 3 | 4 | 8 | 14 | 26 | -12 | 13 | LWLL | 8 | 1 | 3 | 4 | 7 | 10 | 7 | 2 | 1 | 4 | 7 | 16 | ||
| 16 | Villa Española | 15 | 1 | 3 | 11 | 12 | 34 | -22 | 6 | XLLL | 7 | 0 | 2 | 5 | 7 | 15 | 8 | 1 | 1 | 6 | 5 | 19 | ||
| 20 | +2 | Maximiliano SILVERA (Cerrito, 4p) | 
| 16 | Douglas AREZO (River Plate, 6p) | |
| 15 | Gonzalo BERGESSIO (Nacional, 3p) | |
| 14 | Federico MARTÍNEZ (Liverpool, 1p) | |
| 13 | Leandro OTORMÍN (Cerro Largo, 3p) | |
| Agustín ÁLVAREZ (Peñarol) | ||
| 11 | Juan RAMÍREZ (Liverpool, 3p) | |
| 10 | +1 | Sebastián GUERRERO (Torque) | 
| +2 | Ederson RODRÍGUEZ (Rentistas, 3p) | |
| 9 | Lucas RODRÍGUEZ (Torque) | |
| +1 | Lucas DI YORIO (Cerro Largo) | |
| 8 | Renzo LÓPEZ (Plaza Colonia) | |
| Sebastián FERNÁNDEZ (Liverpool, 1p) | ||
| Pablo CEPPELINI (Peñarol, 7p) | ||
| Facundo LABANDEIRA (Boston River) | ||
| +1 | Tomás ANDRADE (Sud América, 4p) | |
| Maureen FRANCO (Fénix, 2p) | ||
| 7 | +1 | Leandro FERNÁNDEZ (Nacional, 2p) | 
| Rubén BENTANCOURT (Peñarol, 1p) | ||
| +1 | Thiago BORBAS (River Plate) | |
| Hernán RIVERO (Wanderers, 1p) | ||
| +1 | Facundo RODRÍGUEZ (Boston River, 1p) | 
| Saturday, 4 December 2021 | ||||||
| 15 | Nacional | 4-2 | River Plate | |||
| 28 | Almeida | 1 | Borbas | |||
| 53(og) | Brunelli | 90 | Montiel | |||
| 61(og) | Brunelli | |||||
| 62 | Fernández | |||||
| 15 | Peñarol | 3-1 | Sud América | |||
| 57 | Canobbio | 71 | Andrade | |||
| 90 | Trindade | |||||
| 90 | Trindade | |||||
| 15 | Wanderers | 1-1 | Fénix | |||
| 89 | Blanco | 62(p) | Pereira | |||
| 15 | Rentistas | 2-3 | Plaza Colonia | |||
| 25 | Rodríguez | 8 | Cruz Mascia | |||
| 33(p) | Rodríguez | 56 | Suhr | |||
| 90 | Umeres | |||||
| 15 | Boston River | 2-1 | Deportivo Maldonado | |||
| 80(p) | Rodríguez | 31 | Viatri | |||
| 90 | González | |||||
| 15 | Torque | 1-0 | Progreso | |||
| 14 | Guerrero | |||||
| Sunday, 5 December 2021 | ||||||
| 15 | Villa Española | 1-1 | Cerro Largo | |||
| 82 | Tizón | 33 | Di Yorio | |||
| 15 | Cerrito | 2-1 | Liverpool | |||
| 79 | Silvera | 72 | Figueredo | |||
| 88(p) | Silvera | |||||
| Play-offs | ||||||
| Tuesday, 7 December 2021 | ||||||
| f | Plaza Colonia | 1-1 | Peñarol | aet, p7-8 | ||
| 35(p) | López | 40 | Torres | |||